Q Xu, R B Scott, D T Tan, E A Shaffer – 1 June 1996 – Impaired gallbladder motility is an established factor in cholesterol gallstone formation. We assessed whether altered small intestinal smooth muscle contractility with slow transit might potentiate gallstone formation by further impeding enterohepatic cycling of bile acids. Ground squirrels were fed a 1% or a trace (controls) cholesterol diet. Small intestinal transit was evaluated from 51Cr distribution in conscious, fasted animals 20 minutes after infusion into the proximal jejunum.

S J Bulera, C A Sattler, H C Pitot – 1 June 1996 – A transgenic rat line carrying the alb‐SV40A transgene has been described by this laboratory. Several cell lines have been established from the livers of two of these rats. One of these cell lines, L37, exhibits a large nuclear/cytoplasmic ratio and a well‐differentiated cytoplasm containing numerous organelles. When L37 cells are placed into culture medium lacking necessary growth factors, cellular proliferation continues for 48 hours after medium change.

K Wadamori, M Oka, N Tokuda, Y Fujikura, S Hazama, T Fukumoto, T Suzuki – 1 June 1996 – We have reported the efficacy of intraarterial‐combined immunochemotherapy including interleukin‐2 (IL‐2) for unresectable hepatocellular carcinoma (HCC). To further test this therapy for prevention of intrahepatic recurrence after hepatectomy, the influence of IL‐2 on liver regeneration was examined using mitotic index (MI) and the bromodeoxyuridine (BrdU) labeling index (LI) in 70% hepatectomized Donryu rats.

T de Baère, A Roche, J M Amenabar, C Lagrange, M Ducreux, P Rougier, D Elias, P Lasser, C Patriarche – 1 June 1996 – Our goal was to determine a subset of patients at high risk of developing liver abscesses after local treatment of liver tumors (LTLT) and establish guidelines for the conduct of LTLT in the safest conditions in such patients. Five hundred sixty‐one LTLT, 489 transhepatic arterial chemoembolizations (TAC, 10 hepatic embolizations, and 62 percutaneous intratumor injections (PIT), were retrospectively reviewed for liver parenchyma necrosis and abscess formation.

T Terada, Y Okada, Y Nakanuma – 1 June 1996 – Matrix metalloproteinases (MMPs) play an important role in cancer cell invasion by degrading extracellular matrix proteins. However, little is known about the in situ expression of MMP in human normal livers and primary liver tumors. In this study, we therefore examined the in situ expression of immunoreactive MMP and tissue inhibitors of MMP (TIMP) in 10 normal livers, 11 surgically resected intrahepatic cholangiocarcinomas (CCs), and 6 surgically resected hepatocellular carcinomas (HCCs).

J M Cullen, P L Marion – 1 June 1996 – We examined 95 ground squirrels to compare the histological appearance of liver sections from animals that were chronically infected with ground squirrel hepatitis virus (GSHV) (n = 29), uninfected (n = 42), or had recovered from infection (n = 24). We studied the effects of long‐term infection because these animals had been infected with GSHV for up to 10 years.

S K Sarin – 1 June 1996

S B Mustafa, K M Howard, M S Olson – 1 June 1996 – Acute endotoxic shock is accompanied by an increase in the production of nitric oxide (NO) by several different hepatic cell types. Platelet‐activating factor (PAF) is a potent proinflammatory mediator with many pathophysiological actions and, in fact, elevated plasma and tissue levels of PAF are observed in animal models of endotoxic shock. The current study demonstrates that PAF induced nitrite formation, the end product of nitric oxide synthesis, by Kupffer cells in a dose‐ and time‐ dependent manner.

L Grande, A Rimola, E Cugat, L Alvarez, J C Garcia‐Valdecasas, P Taurá, J Beltran, J Fuster, A M Lacy, F J González, J Tabet, A Cifuentes, R Rull, C Ramos, J Visa, J Rodés – 1 June 1996 – Although venovenous bypass (VVBP) has been suggested to protect the kidneys during liver transplantation and its systematic use has therefore been recommended, this beneficial effect of VVBP has not been clearly demonstrated.

H Takikawa, Y Sugiyama, J C Fernandez‐Checa, J Kuhlenkamp, M Ookhtens, N Kaplowitz – 1 June 1996 – We previously identified that Y′ bile acid binders (3α‐ hydroxysteroid dehydrogenases) interact with bile acids in intact rat hepatocytes using [3β‐3H, C24‐14C]bile acids and that indomethacin, a competitive inhibitor of 3α‐hydroxysteroid dehydrogenase, inhibits 3H‐loss from the C3‐position of bile acids as well as inhibits hepatic bile acid removal and excretion.