Quantity and location of stone compounds, not the mere presence in small amounts within the stone fabric, are important factors for the correct classification of gallstones and a better knowledge of their pathogenesis

Auxiliary liver transplantation: Regeneration of the native liver and outcome in 30 patients with fulminant hepatic failure–a multicenter European study

M Chenard‐Neu, K Boudjema, J Bernuau, C Degott, J Belghiti, D Cherqui, V Costes, J Domergue, F Durand, J Erhard, B De Hemptinne, G Gubernatis, A Hadengue, J Kemnitz, M McCarthy, H Maschek, G Mentha, K Oldhafer, B Portmann, M Praet, J Ringers, X Rogiers, L Rubbia, S Schalm, F T Kate, O Terpstra, B Van Hoek, R Williams, E Zafrani, J Cinqualbre, P Wolf, D Jaeck, J Bellocq – 1 May 1996 – Auxiliary liver transplantation (LT) is a special procedure of LT which could be proposed to patients with fulminant hepatic failure (FHF) and has for aim that complete regeneration of the native liver (NL) lef

Heat serum inactivation as a mandatory procedure for antiactin antibody detection in cell culture

E L Cancado, L S Vilas‐Boas, C P Abrantes‐Lemos, N F Novo, G Porta, L C Da Silva, A A Laudanna – 1 May 1996 – In autoimmune hepatitis (AIH), the smooth‐muscle antibody is specific for polymerized actin. Detection of antiactin antibody (AAA) has been hampered by technical problems. We have investigated AAA in 30 sera from patients with liver diseases and smooth‐muscle antibody. AAA was detected by indirect immunofluorescence in 1:40, 1:80, and 1:160 dilutions.

A pilot study of corticosteroid priming for lymphoblastoid interferon alfa in patients with chronic hepatitis C

K Chayama, A Tsubota, M Kobayashi, M Hashimoto, Y Miyano, H Koike, M Kobayashi, I Koida, Y Arase, S Saitoh, N Murashima, K Ikeda, H Kumada – 1 May 1996 – Interferon treatment reduces the serum level of hepatitis C virus (HCV) and improves inflammatory activity, but relapse is frequently observed. In an attempt to develop a new therapeutic strategy that may reduce relapse and cure the disease, we evaluated the effect of corticosteroid priming on lymphoblastoid interferon alfa in an open randomized clinical trial.

Relationship between hepatocyte proliferative activity and liver functional reserve in human cirrhosis

M Delhaye, H Louis, C Degraef, O Le Moine, J Deviere, B Gulbis, D Jacobovitz, M Adler, P Galand – 1 May 1996 – Hepatocyte proliferative activity is elevated in cirrhotic patients who develop hepatocellular carcinoma (HCC) and decreased in alcohol‐induced hepatitis patients with poor outcome. Hepatocyte proliferative activity has not been evaluated in an unselected population of cirrhotic patients regarding the severity of the disease.

Elevation of γδ T lymphocytes in peripheral blood and livers of patients with primary sclerosing cholangitis and other autoimmune liver diseases

E B Martins, A K Graham, R W Chapman, K A Fleming – 1 May 1996 – Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that is possibly an autoimmune disease. Although γδ T cells represent a small proportion of the total T‐cell population in healthy individuals, there is evidence to suggest a role for these cells in autoimmunity. Accordingly, the aim of this study was to investigate the population of γδ T cells in patients with PSC, compared with other chronic liver diseases.

Productive infection of primary cultures of endothelial cells from the cat liver sinusoid with the feline immunodeficiency virus

A Steffan, M Lafon, J Gendrault, B Smedsrod, H Nonnenmacher, F Koehren, J Gut, M de Monte, J Martin, C Royer, A Kirn – 1 May 1996 – Given the similarities between the two viruses, the feline immunodeficiency virus (FIV) is becoming an interesting animal model for human immunodeficiency virus (HIV) studies. To explore the still controversial role of the liver in the development of HIV infection, sinusoidal endothelial cells (SEC) were isolated, and primary cultures were infected with the FIV Villefranche IFFA strain.

Quantitative analysis of antibody to hepatitis C virus envelope 2 glycoprotein in patients with chronic hepatitis C virus infection

N Yuki, N Hayashi, A Kasahara, H Hagiwara, E Mita, K Ohkawa, K Katayama, H Fusamoto, T Kamada – 1 May 1996 – The significance of circulating antibody to hepatitis C virus (HCV) envelope glycoprotein 2 (E2)/nonstructural protein 1 (NS1) glycoprotein was studied in 83 patients with chronic HCV infection diagnosed by polymerase chain reaction (PCR). E2/NS1 antibody was quantitatively examined by a passive hemagglutination test using recombinant E2/NS1 glycoprotein encompassing amino acids 388 to 664 of the HCV‐H strain.

Reversible impairment of neonatal hepatobiliary function by maternal cholestasis

M J Monte, A I Morales, M Arevalo, I Alvaro, R I Macias, J J Marin – 1 May 1996 – The effect of total blockage of maternal biliary excretion during the last third of the pregnancy on the maturation of hepatobiliary function was investigated in neonatal rats. Extrahepatic obstruction of the common bile duct on day 14 of pregnancy induced a marked enhancement in serum bilirubin–mainly conjugated bilirubin–and bile acid concentrations as compared with sham‐operated pregnant rats.

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