Pulmonary hypertension after transjugular intrahepatic portosystemic shunt: Effects on right ventricular function

P Van der Linden, O Le Moine, M Ghysels, M Ortinez, J Deviere – 1 May 1996 – The short‐ and mid‐term hemodynamic effects of transjugular intrahepatic portosystemic shunt (TIPS) were studied in 16 sedated cirrhotic patients. Indications included relapsing variceal bleeding (n = 10) and refractory ascites (n = 6).

Kupffer cell depletion by liposome‐delivered drugs: Comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid

N Van Rooijen, A Sanders – 1 May 1996 – Macrophages such as Kupffer cells in the liver are multifunctional cells. They are involved in host defense mechanisms and have a regulatory role in many biomedical processes. Their selective depletion, using liposome‐encapsulated drugs, forms a widely accepted approach to studying their functional aspects in vivo. We have compared the Kupffer cell‐depleting activities of liposome‐encapsulated clodronate, propamidine, and ethylenediaminetetraacetic acid (EDTA) for this purpose.

The effect of posture on central blood volume in patients with preascitic cirrhosis on a sodium‐restricted diet

F Wong, P Liu, Y Allidina, L Blendis – 1 May 1996 – The status of the central blood volume in cirrhosis is controversial. A combination of sodium restriction and upright posture, which redistributes intravascular volume to dependent parts of the body should further aggravate a contracted central blood volume reduction. The aim of this study was to determine the effect of upright posture and sodium restriction on central blood volume (CBV) in preascitic cirrhotic patients, compared with controls.

Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis

N Ganne‐Carrie, C Chastang, F Chapel, C Munz, D Pateron, M Sibony, P Deny, J Trinchet, P Callard, C Guettier, M Beaugrand – 1 May 1996 – The aim of this study was to identify high‐risk patients for hepatocellular carcinoma (HCC). Among 151 patients with histologically proven cirrhosis hospitalized from 1987 to 1990 and prospectively followed‐up until June 1994, 31 developed HCC. We assessed the predictive value of 22 variables recorded at enrollment for HCC occurrence by the log rank test and the Cox proportional hazards model.

Detection of a unique γ‐glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: A new candidate for early diagnosis of hepatocellular carcinoma

M Tsutsumi, D Sakamuro, A Takada, S Zang, T Furukawa, N Taniguchi – 1 May 1996 – Many studies concerning γ‐glutamyl transpeptidase (GGTP) in hepatocellular carcinoma (HCC) have suggested that changes in hepatic GGTP expression may be closely related to the development of HCC. However, its mechanisms are not well known, and genomic analysis of the specific GGTP to HCC is also lacking. Recently, the human GGTP complementary DNA (cDNA) sequences from fetal liver, placenta, and HepG2 cells have been published.

Specificity and sensitivity of gp210 autoantibodies detected using an enzyme‐linked immunosorbent assay and a synthetic polypeptide in the diagnosis of primary biliary cirrhosis

O Bandin, J Courvalin, R Poupon, L Dubel, J Homberg, C Johanet – 1 May 1996 – Between 10% and 42% of patients with primary biliary cirrhosis (PBC) have been reported to have autoantibodies directed against a restricted epitope of gp210, a glycoprotein of the nuclear pore membrane. The prevalence and specificity of these antibodies was studied in a French series of 285 patients with PBC and 497 control individuals affected with other liver or autoimmune diseases.

Cell cycle progression proteins (cyclins), oncogene expression, and signal transduction during the proliferative response of human hepatocytes to hepatocyte growth factor

M J Gomez‐Lechon, I Guillen, X Ponsoda, R Fabra, R Trullenque, T Nakamura, J V Castell – 1 May 1996 – Human hepatocytes stimulated with human recombinant hepatocyte growth factor (h‐rHGF) (10 ng/mL) displayed a characteristic lag period before entering into the S phase. The duration of this delay was dependent on the timing of h‐rHGF addition to cultures. The highest peak of DNA synthesis was observed at 120 hours of culture when hepatocytes were stimulated with h‐rHGF at 72 hours of culture.

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