G A Kullak‐Ublick, U Beuers, G Paumgartner – 1 May 1996 – Bile acids are taken up into human liver by Na+‐dependent and Na+‐independent transport mechanisms. In hepatocarcinogenesis, numerous liver‐specific functions are lost and the uptake of organic anions is markedly reduced. We have investigated the molecular and functional derangements of bile acid transport in the human hepatoblastoma cell line HepG2. Uptake of [3H]‐taurocholic acid was saturable and entirely Na+ independent, with the kinetic characteristics of the human liver organic anion transporting polypeptide (OATP).

K D Lindor, C Bru, R A Jorgensen, J Rakela, J M Bordas, J B Gross, J Rodes, D B McGill, C C Reading, E M James, J W Charboneau, J Ludwig, K P Batts, A R Zinsmeister – 1 May 1996 – The risk of complications from percutaneous liver biopsy is low, but discomfort is common and complications require hospitalization in approximately 4% of patients. The optimal method of performing these biopsies is unknown.

M R Kilmurry, E J Heathcote, K Cauch‐Dudek, K O'Rourke, R J Bailey, L M Blendis, C N Ghent, G Y Minuk, S C Pappas, L J Scully, U P Steinbrecher, L R Sutherland, C N Williams, L J Worobetz – 1 May 1996 – Treatment of patients with primary biliary cirrhosis (PBC) using ursodeoxycholic acid (UDCA) leads to a reduction in serum bilirubin. The first objective of this study was to assess the performance of certain prognostic indicators for PBC after the introduction of treatment with UDCA.

P Martin‐Sanz, M J Diaz‐Guerra, M Casado, L Bosca – 1 May 1996 – Incubation of primary cultures of fetal hepatocytes with lipopolysaccharide (LPS) elicited the expression of nitric oxide (NO) synthetase as well as antagonized the apoptotic cell death evoked by treating the cells with transforming growth factor β1 (TGF‐β1). In addition to LPS, exposure of the cells to chemical NO donors also protected against apoptotic cell death when assayed at concentrations in the low micromolar range.

A O Williams, A D Knapton – 1 May 1996 – Hepatic silicosis, cirrhosis, liver cell adenoma, and carcinomas developed in nude mice (NCr‐Nu) given quartz by the subcutaneous and intraperitoneal routes. Syrian golden hamsters (15:16 EHS:cr) given quartz by both routes developed extensive fibrosis and cirrhosis and had higher morbidity and mortality rates after 3 months. Crystalline silica (quartz) induces fibrosis, adenomas, and carcinomas in the lungs of Fisher 344 rats, but certain strains of mice and hamsters are resistant to quartz‐induced pulmonary carcinogenesis.

1 May 1996

Kevork M. Peltekian, Leonard Makowka, Roger Williams, Laurence M. Blendis, Gary A. Levy, Prostaglandins in Liver Transplantation Research Group – 1 May 1996 – Prostaglandins (PG) are involved in the regulation of many physiological processes in the liver and play a major role in the pathophysiology and treatment of liver diseases. In addition to their effects on cell growth and immune function, PGs have shown cytoprotective effects on hepatocytes in various toxic, ischemic, and infectious models of liver injury.

Cameron N. Ghent, William J. Wall – 1 May 1996

Byers W. Shaw – 1 May 1996

G Marchesini, A Fabbri, G Bianchi, M Brizi, M Zoli – 1 May 1996 – Zinc deficiency is common in cirrhosis and has been involved in the altered nitrogen metabolism. In this study, we measured the effects of zinc supplementation on the dynamics of amino acid‐derived urea synthesis in cirrhosis with mild or latent encephalopathy. The hepatic conversion of amino acids into urea was studied in eight patients with advanced cirrhosis under controlled conditions of substrate availability (continuous alanine infusion), before and after 3‐month oral zinc sulfate supplementation (600 mg/d).