Long‐term octreotide treatment prevents vascular hyporeactivity in portal‐hypertensive rats

C C Sieber, F Lee, R J Groszmann – 1 May 1996 – Chronically portal‐hypertensive rats show in vitro vascular hyporeactivity in large part mediated by the endothelium‐derived vasodilator nitric oxide. We tested whether long‐term octreotide treatment (15 micrograms/kg subcutaneously in 5% D/W, 8‐hourly) corrects the in vitro vascular hyporeactivity.

Vasoactive intestinal peptide in cirrhotic rats: Hemodynamic effects and mesenteric arterial receptor characteristics

S S Lee, M Huang, Z Ma, O Rorstad – 1 May 1996 – Vasoactive intestinal peptide (VIP) blood levels in cirrhosis are elevated, but its hemodynamic and receptor characteristics remain unclarified. We aimed to quantify VIP receptor characteristics in mesenteric arteries, plasma VIP concentration by radioimmunoassay (RIA), and the hemodynamic effects of VIP infusion in bile duct‐ligated (BDL) cirrhotic and sham‐operated control rats. Mesenteric arterial membranes were prepared by ultracentrifugation, and receptor characteristics were studied using 125I‐labeled VIP as a radioligand.

Sanctuary of hepatitis B virus in bone‐marrow cells of patients undergoing liver transplantation

Yaron Ilan, Eitan Galuns, Arnon Nagler, Yaakov Baruch, Nelli Livni, Ran Tur‐Kaspa – 1 May 1996 – Hepatitis B virus (HBV) reinfection after liver transplantation is a major problem. HBV is mainly a hepatotrophic virus but replicates in many extrahepatic tissues. We present here two cases of infected patients who underwent liver transplantation. Both underwent bone marrow (BM) and liver biopsies after transplantation. Biopsy specimens were stained for hepatitis B surface antigen (HBsAg), and bone marrow aspirates and were separated for all subsets of cells.

Failed allografts and causes of death after orthotopic liver transplantation from 1985 to 1995: Decreasing prevalence of irreversible hepatic allograft rejection

Jurgen Ludwig, Etsuko Hashimoto, Michael K. Porayko, Terry M. Therneau – 1 May 1996 – Mayo Clinic pathology files from March 1985 to March 1995 contained records of 584 orthotopic liver transplantations in 515 patients. The most common indication for liver transplantation was primary sclerosing cholangitis (PSC), followed by primary biliary cirrhosis (PBC), and cryptogenic cirrhosis. In 59 patients, a total of 69 single or repeated retransplantations became necessary.

Pulmonary hypertension after transjugular intrahepatic portosystemic shunt: Effects on right ventricular function

P Van der Linden, O Le Moine, M Ghysels, M Ortinez, J Deviere – 1 May 1996 – The short‐ and mid‐term hemodynamic effects of transjugular intrahepatic portosystemic shunt (TIPS) were studied in 16 sedated cirrhotic patients. Indications included relapsing variceal bleeding (n = 10) and refractory ascites (n = 6).

Kupffer cell depletion by liposome‐delivered drugs: Comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid

N Van Rooijen, A Sanders – 1 May 1996 – Macrophages such as Kupffer cells in the liver are multifunctional cells. They are involved in host defense mechanisms and have a regulatory role in many biomedical processes. Their selective depletion, using liposome‐encapsulated drugs, forms a widely accepted approach to studying their functional aspects in vivo. We have compared the Kupffer cell‐depleting activities of liposome‐encapsulated clodronate, propamidine, and ethylenediaminetetraacetic acid (EDTA) for this purpose.

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