A new step toward standardization of serum hepatitis C Virus–RNA quantification in patients with chronic hepatitis C

Michèle Martinot‐Peignoux, Nathalie Boyer, Véronique Le Breton, Gaëlle Le Guludec, Corinne Castelnau, Raoudha Akremi, Patrick Marcellin – 30 December 2003 – The need to improve efficacy of antiviral therapy for chronic hepatitis C has prompted the development of quantitative assays, which allows the assessment of viral load before therapy.

Insulin‐like growth factor‐I reverts testicular atrophy in rats with advanced cirrhosis

Inma Castilla‐Cortazar, Maria Garcia, Jorge Quiroga, Nieves Diez, Fernando Diez‐Caballero, Alfonso Calvo, Matias Diaz, Jesus Prieto – 30 December 2003 – The pathogenesis of hypogonadism in cirrhosis is not completely understood. The levels of insulin‐like growth factor‐I (IGF‐I), an anabolic factor with trophic actions on testes, are reduced in cirrhosis. This study was undertaken to evaluate whether rats with advanced cirrhosis develop hypogonadism and whether the administration of IGF‐I exerts beneficial effects on testicular structure and function.

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