A Piperno, C Arosio, S Fargion, A Roetto, C Nicoli, D Girelli, L Sbaiz, P Gasparini, G Boari, M Sampietro, C Camaschella – 1 July 1996 – We evaluate the relation between genotype and phenotype in 47 Italian male patients with homozygous genetic hemochromatosis (GH). Phenotype evaluation was based on the ratio of amount of iron removed (IR) by phlebotomy and age (IR/age). Patients were divided in two classes of phenotype expression: class I included 26 patients with less severe iron overload (IR/age ≤0.33) and class II included 21 patients with a more marked one (IR/age >0.33).

P D Berk – 1 July 1996

Nina Singh, Timothy Gayowski, Ignazio R. Marino – 1 July 1996 – Toxoplasma gondii pneumonia developed 27 days after retransplantation for chronic rejection in a liver transplant recipient receiving tacrolimus as primary immunosuppression. Trimethoprim‐sulfamethoxazole had been discontinued (due to cytopenia) before the onset of T gondii pneumonia. T gondii was isolated from bronchoalveolar lavage fluid by growth in fibroblast cell culture routinely used for the isolation of viruses and detected in lung on autopsy.

B A Haber, E Chuang, W Lee, R Taub – 1 July 1996 – Patients with hereditary tyrosinemia type 1 have a deficiency of fumarylacetoacetate hydrolase (FAH) and develop progressive hepatocellular dysfunction with a high risk of malignant transformation. Serum alpha‐fetoprotein levels are frequently elevated in these patients; therefore, this commonly used marker of tumorigenesis is inadequate. To date, no literature exists describing the hepatic gene alterations in patients with this disease.

W Liu, O Schöb, J E Pugmire, D Jackson, K A Zucker, D E Fry, R H Glew – 1 July 1996 – Advances in liver surgery and transplantation have lead to a steady increase in the number of these interventions. Prompt quantitative assessment of hepatic of hepatic function and a patient's subsequent morbidity and mortality following surgery remain difficult despite the currently utilized historic markers of hepatic parenchymal injury (e.g., aspartate transaminase [AST], lactate dehydrogenase [LDH] γ‐glutamyl transpeptidase [GGT]).

D C Rockey, R A Weisiger – 1 July 1996 – Hepatic stellate cells are similar to tissue pericytes and have been shown to be contractile. In this study, we examined the effects of known mediators of stellate cell contraction on portal pressure in rat livers after carbon tetrachloride induced injury (including cirrhosis) and investigated the contractility of stellate cells as a function of liver injury.

F Wehner, R K Kinne, E Petzinger – 1 July 1996

1 July 1996

A D'Errico, M Fiorentino, A Ponzetto, Y Daikuhara, H Tsubouchi, C Brechot, J Scoazec, W F Grigioni – 1 July 1996 – Increased levels of expression of hepatocyte growth factor (HGF) and its specific receptor c‐met have been shown in the liver of several benign and malignant pathologies, both in experimental models and humans. We investigated by immunohistochemistry the presence of both HGF and c‐met protoocogene product (c‐met pp) in 20 hepatocellular carcinomas (HCCs), 5 focal nodular hyperplasias (FNHs), 4 cases of fulminant hepatitis (FH), and 1 case of regenerated liver.

D Fukumura, Y Yonei, I Kurose, H Saito, T Ohishi, H Higuchi, S Miura, S Kato, H Kimura, H Ebinuma, H Ishi – 1 July 1996 – The metabolic change in tumor cells (AH70, a rat hepatoma cell line) cocultured with isolated rat Kupffer cells were visualized and analyzed by a laser scanning confocal imaging system. When AH70 cells were cocultured with Kupffer cells, fluorescence intensity of rhodamine 123 (Rh123) decreased, indicating the reduction of mitochondrial function.