Esteban Mezey, Lynda Rennie‐Tankersley, James J. Potter – 30 December 2003 – Dihydrotestosterone decreased alcohol dehydrogenase (ADH) activity and enzyme‐protein in rat hepatocytes in culture. This effect was observed after the hepatocytes had been exposed to dihydrotestosterone for 3 days at concentrations of 0.5 μmol/L or higher. Dihydrotestosterone did not decrease alcohol dehydrogenase messenger RNA (mRNA) but, rather, resulted in small increases in ADH mRNA after 3 days of exposure.

Elisa M. Konieczko, Amy K. Ralston, Aleta R. Crawford, Saul J. Karpen, James M. Crawford – 30 December 2003 – Although bile salts are toxic to the liver at high plasma concentrations, the effects of physiological concentrations of bile salts on normal hepatic function are poorly understood. We examined the effect of taurocholate (TC) on the basolateral uptake of [3H]TC in WIF‐B cells, a hybrid cell line stably exhibiting in vitro the structural and functional polarity of hepatocytes.

Hannu Raunio, Risto Juvonen, Markku Pasanen, Olavi Pelkonen, Paavo Pääkkö, Ylermi Soini – 30 December 2003 – The hepatic cytochrome P4502A6 (CYP2A6) enzyme mediates the oxidative metabolism of several procarcinogens that have liver as their primary target. Mouse models indicate that liver tumors invariably overexpress CYP2A forms, and that inflammation and cirrhosis may regulate the CYP2A expression pattern. In this study, the distribution of the CYP2A6 protein was investigated in a series of 24 human hepatocellular carcinoma (HCC) samples by immunohistochemical analysis.

Marielle Delnomdedieu, Laurence W. Hedlund, Robert R. Maronpot, G. Allan Johnson – 30 December 2003 – The development of magnetic resonance (MR) microscopy has provided new approaches to histology and histopathology. Recent work has shown the promise of increased sensitivity in animal models of chemically induced hepatotoxicity. However, the field is so new that there is little experience to relate changes seen in MR micrographs to the more traditional optical images stained with hematoxylin and eosin.

Ala I. Sharara, Don C. Rockey – 30 December 2003

Dhiraj Tripathi, Peter C. Hayes – 30 December 2003

30 December 2003

30 December 2003

Eve A. Roberts, Michael L. Schilsky – 30 December 2003

Neil Kaplowitz – 30 December 2003