Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C

Michele Martinot‐Peignoux, Patrick Marcellin, Mièle Pouteau, Corinne Castelnau, Nathalie Boyer, Marc Poliquin, Claude Degott, Isabelle Descombes, Véronique Le Breton, Véronica Milotova, Jean Pierre Benhamou, Serge Erlinger – 1 October 1995 – The aim of the study was to determine the respective influence of pretreatment serum hepatitis C virus (HCV) RNA levels and HCV genotype on the response to interferon (IFN) alfa in patients with chronic hepatitis C. We retrospectively studied 141 patients with chronic hepatitis C included in two consecutive controlled trials of IFN alfa.

Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation

Luba Dumenco, Delphine Oguey, Justina Wu, Norma Messier, Nelson Fausto – 1 October 1995 – The p53 gene is frequently mutated in human tumors; in hepatocellular carcinomas, there is a high frequency of a specific mutation at codon 249 in regions with significant aflatoxin exposure. To assess the role of this p53 mutation in the development of hepatocellular carcinoma, a mutant murine p53 gene, p53ser246, which corresponds to human codon 249, was transfected into a differentiated, nontransformed hepatocyte cell line AML12.

Carbon tetrachloride–induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: Effect of S‐adenosylmethionine treatment

Gregorio Varela‐Moreiras, Elena Alonso‐Aperte, Mireia Rubio, Marta Gasso, Ramón Deulofeu, Luis Alvarez, Juan Caballería, Juan Rodés, José M. Mato – 1 October 1995 – Carbon tetrachloride (CCl4) administration to rats produces hepatic cirrhosis and supplementation with S‐adenosylmethionine (SAM) can partially prevent CCl4‐induced liver injury. These effects are thought to be caused by oxidative stress and the subsequent formation of free radicals, but the mechanism whereby this occurs and the accurate nature of the mechanisms by which SAM exerts its protective action are not well understood.

Subcellular distribution of large and small hepatitis delta antigen in hepatocytes of hepatitis delta virus superinfected woodchucks

John M. Cullen, Caroline David, Jia‐Gang Wang, Paul Becherer, Stanley M. Lemon – 1 October 1995 – Hepatitis delta virus (HDV) encodes only a single protein, the hepatitis delta antigen (HDAg), which is expressed as two molecular forms (large and small) with different functions in viral replication. Compared with small antigen, large antigen has a 19 residue carboxyl terminal extension.

Characteristic difference of hepatocellular carcinoma between hepatitis B‐ and C‐ viral infection in Japan

Yasushi Shiratori, Shuichiro Shiina, Masatoshi Imamura, Naoya Kato, Fumihiko Kanai, Takahito Okudaira, Takuma Teratani, Gohichi Tohgo, Nobuo Toda, Makoto Ohashi, Keiji Ogura, Yasuro Niwa, Takao Kawabe, Masao Omata – 1 October 1995 – Characteristics of 205 consecutive patients with hepatocellular carcinoma (HCC) admitted during 1990 to 1993 have been analyzed from the standpoint of hepatitis viral infection in Japan.

Intrahepatic mast cells in chronic liver diseases

Desmond J. Farrell, Julie E. Hines, Andrew F. Walls, Peter J. Kelly, Mark K. Bennett, Alastair D. Burt – 1 October 1995 – Mast cells are known to be present in human liver but their distribution and density in normal livers and in chronic liver diseases have not previously been examined. In this study, we quantified mast cell numbers and examined their distribution in percutaneous biopsy specimens from normal livers (n = 8) and in two chronic progressive liver diseases: primary biliary cirrhosis (PBC) (n = 40) and alcoholic liver disease (n = 33).

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