Effects of liver transplantation on bile formation and biliary lipid secretion in the Sprague‐Dawley rat

Francis K. L. Chan, Yikun Zhang, Francis R. Sutherland, Eldon A. Shaffer – 1 October 1995 – Altered hepatic secretory function after orthotopic liver transplantation constitutes a major perioperative clinical problem. Cholestasis and cholesterol gallstone formation are among the most frequent complications reported. Such changes in the allograft secretory function can be secondary to many factors like graft injury due to preservation and marked rejection, surgical complications, immunosuppressive therapy, and sepsis.

Differential expression of A and B laminin chains during rat liver regeneration

América Giménez, Joaquim Hostench, Stamatis C. Stamatoglou, Carlos Enrich – 1 October 1995 – We have studied the distribution and expression of laminin during rat liver regeneration by immunofluorescence and immunoblotting using affinity‐purified laminin antibodies. Laminin was localized on sinusoidal surfaces in normal and regenerating hepatic parenchyma, but enhanced expression was detected during regeneration from 6 hours to 7 days after a partial hepatectomy.

Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease

Seiichiro Kamimura, Hidekazu Tsukamoto – 1 October 1995 – Kupffer cell‐derived cytokines are believed to play pivotal paracrine roles in the pathogenesis of alcoholic liver disease (ALD). To evaluate this hypothesis, Kupffer cell gene expression of tumor necrosis factor‐alpha (TNFα), interleukin (IL)‐6, and transforming growth factor‐beta 1 (TGFβ1) were directly examined in the rat model of ALD. Kupffer cells were isolated from the model after 10 and 17 weeks of intragastric ethanol infusion. These two durations resulted in focal hepatocellular injury and liver fibrogenesis, respectively.

Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: A multivariate analysis

Masayoshi Yamauchi, Yoshihiko Maezawa, Yuji Mizuhara, Mitsuru Ohata, Junichi Hirakawa, Hisato Nakajima, Gotaro Toda – 1 October 1995 – Alcohol dehydrogenase (ADH), aldehyde dehydrognase (ALDH), and P450IIE1 are the primary enzymes that catalyze the conversion of ethanol to acetaldehyde and then to acetate. Genetic polymorphisms have been reported in ADH2, ADH3, ALDH2, and the 5′‐flanking region of P450IIEI.

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