Hepatic allograft rejection is associated with increased levels of soluble intercellular adhesion molecule‐1

Dora Ninova, Ruud A. F. Krom, Russell H. Wiesner – 1 September 1995 – Intercellular adhesion molecule‐1 (ICAM‐1) is an adhesion molecule from the immunoglobulin super family that is recognized to be an important factor in the multistep process of cell transendothelial migration and lymphocyte adhesion during antigen recognition and effector cytolysis, mechanisms known to be involved in the pathogenesis of hepatic allograft rejection. A soluble form of ICAM‐1 (sICAM‐1) can be shed into the circulation.

Iron‐responsive element‐binding protein in hemochromatosis liver and intestine

Peter R. Flanagan, Attila Hajdu, Paul C. Adams – 1 September 1995 – Iron‐responsive element‐binding protein (IRE‐BP) activity was studied in liver and intestinal samples of hemochromatosis and control patients using a short 32P‐IRE‐RNA probe on “retardation” nondenaturing polyacrylamide gels. IRE‐BP activity was assessed in liver biopsy specimens in 36 patients—16 hemochromatosis homozygotes, 4 hemochromatosis heterozygotes, 6 patients with secondary iron overload, and 10 control patients with normal hepatic iron concentrations.

Long‐term effect of nadolol or nadolol plus isosorbide‐5‐mononitrate on renal function and ascites formation in patients with cirrhosis

Carlo Merkel, Angelo Gatta, Carlo Donada, Edda Enzo, Renato Marin, Piero Amodio, Pierluigi Torboli, Paolo Angeli, Giorgio Cavallarin, Giuliana Sebastianelli, Sara Susanna, Cesare Mazzaro, Pietro Beltrame, The GTIP – 1 September 1995 – The association beta‐blockers plus nitrates has been reported to impair renal function and renal sodium handling, leading to increased risk of development of ascites, or worsening of a preexisting ascites, or increase in the requirements of diuretic agents.

Hepatic distribution of E2 component of pyruvate dehydrogenase complex after transplantation

James Neuberger, Lorraine Wallace, Ruth Joplin, Stefan Hubscher – 1 September 1995 – We have examined the distribution of the E2 component of pyruvate dehydrogenase complex in the liver of patients with native primary biliary cirrhosis (PBC), and after transplantation, using affinity‐purified anti‐E2 antibodies. In the posttransplantation group, we studied biopsy specimens from patients grafted for conditions other than PBC (n = 6) and those grafted for PBC with (n = 6) and without (n = 5) histological features suggestive of PBC recurrence.

Randomized trial comparing three different regimens of alpha‐2a‐interferon in chronic hepatitis C

Liliana Chemello, Paola Bonetti, Luisa Cavalletto, Fabiola Talato, Valter Donadon, Pietro Casarin, Fabio Belussi, Mario Frezza, Franco Noventa, Patrizia Pontisso, Luisa Benvegnù, Carla Casarin, Alfredo Alberti, The TriVeneto Viral Hepatitis Group – 1 September 1995 – Alpha‐interferon (IFN‐α) is an effective treatment for chronic hepatitis C, but only 20% to 30% of patients are apparently cured with the currently recommended schedule of 3 MU given three times a week for 6 months.

In vitro activation of woodchuck lymphocytes measured by radiopurine incorporation and interleukin‐2 production: Implications for modeling immunity and therapy in hepatitis B virus infection

Paul J. Cote, John L. Gerin – 1 September 1995 – Cellular immune responses to hepatitis B virus (HBV) play an important role in the resolution of acute infection. They also influence the course of chronic infection and disease but are inadequate to completely clear the infection. Woodchuck hepatitis virus (WHV) infection of the woodchuck can provide a model to study these processes.

Liver transplantation and the alcoholic patient:Medical, surgical, and psychosocial issues by Michael R. Lucey, Michael R. Lucey, Robert M. Marian, Thomas P. Beresford. 134 pp. New York, NY: Cambridge University Press, 1994 $49.95

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