Koert P. de Jong, Harold E. Lont, Amelie M. Bijma, Mark A. M. Brouwers, Elisabeth G. E. de Vries, Marco L. van Veen, Richard L. Marquet, Maarten J. H. Slooff, Onno T. Terpstra – 1 October 1995 – Residual tumor in the remnant liver after partial hepatectomy (PH) for colorectal liver metastases is a serious clinical problem. This fact is reflected by the high number of recurrences after potentially curative liver resections. Liver regeneration, it appears, might influence the growth of remaining micrometastases in the liver.

James F. Whiting, Richard M. Green, Adam B. Rosenbluth, John L. Gollan – 1 October 1995 – Tumor necrosis factor–alpha (TNF,α), a cytokine that is produced in a variety of inflammatory diseases associated with cholestasis, is believed to be the primary mediator of the systemic effects of endotoxin. Thus, we have investigated the role of TNFα in the pathogenesis of endotoxin‐induced cholestasis in intact animals, and in the uptake of taurocholate by cultured hepatocytes.

1 October 1995

George Marinos, Francesco Torre, Shilpa Chokshi, Munther Hussain, Berwin E. Clarke, David J. Rowlands, Adrian L. W. F. Eddleston, Nikolai V. Naoumov, Roger Williams – 1 October 1995 – The T helper (Th) cell response to hepatitis B core antigen (HBcAg) was analyzed in 76 chronic hepatitis B virus (HBV) carriers with varying degrees of hepatic inflammation and HBV replication. Fifty‐five patients had active viral replication, 28 with minimal histological changes and normal alanine transaminase (ALT) and 27 with active hepatic inflammation and elevated ALT.

Keith D. Lindor, E. Rolland Dickson, Roberta A. Jorgensen, Monte L. Anderson, Russell H. Wiesner, Gregory J. Gores, Stephen M. Lange, Steven S. Rossi, Alan F. Hofmann, William P. Baldus – 1 October 1995 – Ursodeoxycholic acid (UDCA) and methotrexate (MTX) have both been proposed as treatments for patients with primary biliary cirrhosis (PBC). It has been suggested that a combination of the two drugs may offer advantages over either used separately. In this pilot study, we sought to evaluate the safety and efficacy of this combination for patients with PBC.

Albert D. Min, Henry C. Bodenheimer – 1 October 1995

Katsuya Shiraki, Koujirou Takase, Yukihiko Tameda, Minoru Hamada, Yoshitane Kosaka, Takeshi Nakano – 1 September 1995 – Levels of two types of lectin‐reactive alpha‐fetoprotein (AFP), designated AFP‐L3 and AFP‐P4+P5, were analyzed with Lens culinaris agglutinin A and AFP‐P4+P5 with erythroagglutinating phytohemagglutinin, respectively, in an attempt to determine the utility and significance of these macromolecules as early indicators of hepatocellular carcinoma during the periodic follow‐up of cirrhotic patients.

1 September 1995

Stephen D. Ryder, John Koskinas, Paolo M. Rizzi, Ian G. McFarlane, Bernard C. Portmann, Nikolai V. Naoumov, Roger Williams – 1 September 1995 – The risk of hepatocellular carcinoma in autoimmune hepatitis is low, even in patients with long‐standing cirrhosis. Because of the increasing recognition of an association of hepatitis C virus (HCV) with autoimmune hepatitis, at least in some geographical areas, and with hepatocellular carcinoma (HCC) (hepatoma), we have examined eight cases (4 male, 4 female) who presented between 1985 and 1993 with hepatoma complicating autoimmune hepatitis.

Fin Stolze Larsen, Karsten Skovgaard Olsen, Ellen Ejlersen, Bent Adel Hansen, Olaf B. Paulson, Gitte Moos Knudsen – 1 September 1995 – Impairment of cerebral blood flow (CBF) autoregulation may have serious implications for patients with cirrhosis if arterial hypotension occurs during coma, anesthesia, bleeding, or sepsis. In this study, CBF autoregulation was investigated in patients with cirrhosis with no or mild encephalopathy. Ten patients (median age, 45 years; range, 30 to 61 years) and six healthy volunteers (median age, 30 years; range, 21 to 61 years) were included.