Bruno Turlin, Gabriella I. Slapak, Karen M. Hayllar, Nigel Heaton, Roger Williams, Bernard Portmann – 1 September 1995 – Centrilobular necrosis (CLN) is a histological finding often encountered after orthotopic liver transplantation, but its pathogenesis is still unknown. In this study, the significance of CLN was assessed in a series of 227 consecutive liver transplantations performed between January 1989, and December 1991. Seventy‐one patients (30.9%) showed CLN on at least one biopsy result, which were obtained because of an increase of aspartate aminotransferase activity.

Kenneth J. Hardy, Somsit Tancheroen, Arthur Shulkes – 1 September 1995 – The aim of the study was to determine if pretreatment with misoprostol (a prostaglandin analogue) or nifedipine (a calcium antagonist), known protectants of the whole liver, would ameliorate the ischemia‐reperfusion injury (IRI) of resected liver associated with vascular occlusion.

Burton Combes, Robert L. Carithers, Willis C. Maddrey, Danyu Lin, Mary F. McDonald, Donald E. Wheeler, Edwin H. Eigenbrodt, Santiago J. Muñoz, Raphael Rubin, Guadalupe Garcia‐Tsao, Gregory F. Bonner, Alexander B. West, James L. Boyer, Velimir A. Luketic, Mitchell L. Shiffman, A. Scott Mills, Marion G. Peters, Heather M. White, Rowen K. Zetterman, Stephen S. Rossi, Alan F. Hofmann, Rodney S. Markin – 1 September 1995 – One hundred fifty‐one patients with primary biliary cirrhosis (PBC) grouped into four strata based on entry serum bilirubin (<2 mg/dL vs.

Mario Angelico, Andrea Mangiameli, Alessandra Nistri, Leonardo Baiocchi, Mara Sofia, Mario Maina, Mario Di Martino, Adriano Blasi – 1 September 1995 – The purpose of this study was to investigate the physicochemical/biological properties and the effects of acute administration of N‐ethyl‐tauroursodeoxycholic acid in bile‐fistula rats. In vitro determination of high‐performance liquid chromatography mobility, octanol/water partitioning, cholesterol solubilizing capacity, and sensitivity to enzyme deconjugation by bacteria and cholylglycine‐hydroxylase were performed.

Barbara Haber, Leyla Naji, Drew Chessman, Rebecca Taub – 1 September 1995 – The liver shows maximal cellular growth during fetal development and after partial hepatectomy. Exploring overlaps in gene expression patterns in these two types of hepatic growth may provide insight into common regulatory pathways. The expression of a large number of growth‐induced and liver‐specific genes induced in liver regeneration has been examined in the perinatal liver from several days prenatal to 4 weeks postnatal when the major growth phase of the liver ceases.

Joseph A. Awad, Jason D. Morrow – 1 September 1995 – Lipid peroxidation is believed to be an important mechanism of liver injury caused by some xenobiotics. However, it has been difficult to demonstrate and quantify this process in vivo. Moreover, little is known about the disposition of lipids oxidized in the liver. F2‐isoprostanes are prostanoids produced by nonenzymatic free radical‐catalyzed peroxidation of arachidonic acid esterified to phospholipids. Hydrolysis of F2‐isoprostanes from phospholipids by phospholipases yields free F2‐isoprostanes.

Byers W. Shaw – 1 September 1995

Nezam H. Afdhal, Niu Niu, David P. Nunes, Rama Bansil, Xing Xiang Cao, Donald Gantz, Donald M. Small, Gwynneth D. Offner – 1 September 1995 – Nucleation of cholesterol monohydrate crystals from bile is a critical step in the formation of cholesterol gallstones. Measurement of nucleation in model bile systems and the characteristics of the initial nucleus have proven elusive.

Judith K. Mickelson, Gilbert Kukielka, J. Stanley Bravenec, Elizabeth Mainolfi, Robert Rothlein, Hal K. Hawkins, James H. Kelly, C. Wayne Smith – 1 September 1995 – Intercellular adhesion molecule‐1 (ICAM‐1, CD54) is upregulated in many cell types stimulated by cytokines.

Alpha T. Banks, Hyman J. Zimmerman, Kamal G. Ishak, John G. Harter – 1 September 1995 – Diclofenac is a nonsteroidal anti–inflammatory drug approved in the United States in 1988 for the treatment of patients with osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis.