Roger L. Jenkins – 1 July 1995

Kazuhiko Koizumi, Nobuyuki Enomoto, Masayuki Kurosaki, Takeshi Murakami, Namiki Izumi, Fumiaki Marumo, Chifumi Sato – 1 July 1995 – Hepatitis C virus (HCV) populations in vivo exist as a mixture of heterogeneous viruses called quasispecies, which have variations in the hypervariable region (HVR). However, the relationship between the diversity of HVR quasispecies, the disease stage, or the interferon (IFN) responsiveness remains to be elucidated.

Kenji Takenaka, Kazuharu Yamamoto, Akinobu Taketomi, Hidetoshi Itasaka, Eisuke Adachi, Ken Shirabe, Takashi Nishizaki, Katsuhiko Yanaga, Keizo Sugimachi – 1 July 1995 – To assess the differences in the surgical results between patients with hepatitis B‐ and hepatitis C‐related hepatocellular carcinoma (HCC), the operative outcomes of 30 patients with hepatitis B surface antigen (HBsAg)‐positive (the B‐HCC group) and 96 patients with hepatitis C antibody (HCVAb)‐positive (the C‐HCC group), who had undergone hepatic resection from 1989 to 1993, were compared.

Hau‐Tim Chung, Ching‐Lung Lai, Anna S. F. Lok – 1 July 1995 – This study was conducted to determine the rate of detection of serum hepatitis B virus (HBV) DNA in hepatitis B surface antigen (HBsAg)‐negative decompensated cirrhotic patients who had hepatitis B core and/or surface antibodies (anti‐HBc and/or anti‐HBs), and to compare the outcome of HBsAg‐positive cirrhotic patients who did or did not clear HBsAg during follow‐up. Six (5%) of 121 HBsAg‐positive cirrhotic patients lost HBsAg after 0.2 to 17.1 years (mean, 9.1 ± 6.2 yr) of follow‐up.

Hanns F. Löhr, Wolfgang Weber, Jörg Schlaak, Bernd Goergen, Karl‐Hermann Meyer Zum Büschenfelde, Guido Gerken – 1 July 1995 – To assess the significance of cell‐mediated immunity, T cells were derived from the peripheral blood and liver tissue of hepatitis B virus (HBV)‐infected patients and controls.

Kris V. Kowdley, Tarek Hassanein, Sumanjit Kaur, Frank J. Farrell, David H. van Thiel, Emmet B. Keeffe, Michael F. Sorrell, Bruce R. Bacon, Frederick L. Weber, Anthony S. Tavill – 1 July 1995 – Cirrhotic patients with hereditary hemochromatosis (HHC) have an increased risk of primary liver cancer (PLC). The purpose of this study was to determine the prevalence of primary liver cancer in patients with HHC undergoing orthotopic liver transplantation (OLT).

Didier Samuel, Graeme Alexander – 1 July 1995

Debra L. Laskin, Marina Rodriguez Del Valle, Diane E. Heck, Shaw‐Min Hwang, S. Tsuyoshi Ohnishi, Stephen K. Durham, Nancy L. Goller, Jeffrey D. Laskin – 1 July 1995 – In the present studies, we analyzed the effects of acute endotoxemia on hepatocyte nitric oxide production and functional activity. Treatment of rats with 5 mg/kg of lipopolysaccharide (LPS), which induces acute endotoxemia, caused an increase in nitric oxide production in the liver, as measured by electron paramagnetic spin trapping, which was evident within 6 hours.

Richard A. Rippe, Ghamen Almounajed, David A. Brenner – 1 July 1995 – Ito cells are the primary cell type in the liver responsible for increased type I collagen production observed during fibrogenesis. After a fibrogenic stimulus, Ito cells change from their normal quiescent state to an activated state. In this study, we examined the expression of the α1(I) collagen gene in Ito cells that were freshly isolated from normal rat liver (quiescent) and Ito cells that were activated by culture on plastic.

Jürgen G. Pauletzki, Qi‐Wei Xu, Eldon A. Shaffer – 1 July 1995 – Impaired gallbladder emptying is frequent in cholesterol gallstone disease as well as in predisposing conditions like pregnancy and obesity. Gallbladder hypomotility is considered a pathogenic factor for gallstone formation, providing the residence time for cholesterol crystal nucleation, but any effect on the enterohepatic circulation of bile acids and subsequently on biliary lipid composition is unknown.