Martín Prieto, Vicente Olaso, Clara Verdú, Juan Córdoba, Concepción Gisbert, Miguel Rayón, Domingo Carrasco, Marina Berenguer, María Dolores Higón, Joaquín Berenguer – 1 August 1995 – To determine whether the presence of hepatitis C virus (HCV) viremia correlates with the severity of liver disease in anti‐HCV‐positive apparently healthy blood donors, we studied 98 blood donors found positive for anti‐HCV using enzyme‐linked immunosorbent assay (ELISA).

Yukihiro Shimizu, Masami Minemura, Takashi Tsukishiro, Yoshirou Kashii, Megumi Miyamoto, Hiroshi Nishimori, Kiyohiro Higuchi, Akiharu Watanabe – 1 August 1995 – Serum levels of soluble forms of intercellular adhesion molecule–1 (sICAM‐1) and lymphocyte function‐associated antigen‐3 (sLFA‐3) in 122 patients with chronic liver disease including hepatocellular carcinoma (HCC) were measured by enzyme‐linked immunosorbent assays. Serum levels of sICAM‐1 in patients with HCC were significantly higher than those of chronic hepatitis (CH) and cirrhosis.

Hiroshi Nakano, Karim Boudjema, Eliane Alexandre, Pierre Imbs, Marie Pierre Chenard, Philippe Wolf, Jacques Cinqualbre, Daniel Jaeck – 1 August 1995 – We investigated whether intraportal injection of 150 mg/kg N‐acetylcysteine (NAC) into rats reduced hepatic ischemia‐reperfusion injury after 48 hours of cold storage and 2 hours of reperfusion. The organ was isolated and perfused to evaluate liver function. The control group received an intraportal injection of 5% dextrose. NAC increased L‐cysteine concentrations 15 minutes after injection (1.29 ± 0.11 μmol/g vs.

Ansgar Wilhelm Lohse, Matthias Kögel, Karl‐Hermann Mermer Zum Büschenfelde – 1 August 1995 – Autoimmune hepatitis (AIH) runs a variable clinical course. Slow disease progression or even spontaneous remissions can be observed and suggest that the autoimmune process can, at least to a certain extent, be controlled by regulatory elements of the patient's own immune system. In experimental autoimmune hepatitis (EAH) spontaneous recovery is regularly observed and associated with antigen‐specific and antigen‐nonspecific suppression.

Patrick S. C. Leung, David T. Chuang, R. Max Wynn, Sanghoon Cha, Dean J. Danner, Aftab Ansari, Ross L. Coppel, M. Eric Gershwin – 1 August 1995 – Primary biliary cirrhosis (PBC) is an autoimmune disease of liver associated with a unique serologic response to mitochondrial autoantigens. Many of the autoantigens recognized by autoantibodies in PBC are members of the 2‐oxo‐acid dehydrogenase complex. The two major autoantigens are the E2 component of the pyruvate dehydrogenase complex (PDC‐E2) and the E2 component of the branched chain 2‐oxo‐acid dehydrogenase complex (BCOADC‐E2).

Peter R. Sinclair, Nadia Gorman, Jacqueline F. Sinclair, Heidi S. Walton, William J. Bement, Richard W. Lambrecht – 1 August 1995 – Ascorbate was previously shown to suppress accumulation of uroporphyrin (URO) in cultured chick embryo hepatocytes and to competitively inhibit microsomal oxidation of uroporphyrinogen catalyzed by cytochrome P4501A2.

Shigeo Sugano, Tokuya Suzuki, M. Vaubourdolle, O. Chazouilleres, R. Poupon, J. Giboudeau – 1 August 1995

Nobukazu Yuki, Norio Hayashi, Kazuyoshi Ohkawa, Hideki Hagiwara, Masahide Oshita, Kazuhiro Katayama, Yutaka Sasaki, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada – 1 August 1995 – The significance of immunoglobulin (Ig) M antibody to hepatitis C virus core protein (IgM anti‐HCVcore) was studied in 41 patients with chronic hepatitis C virus (HCV) infection diagnosed by the polymerase chain reaction (PCR). IgM anti‐HCVcore was tested with a solid‐phase enzyme‐linked immunoassay.

Jiezhong Chen, Michael Murray, Christopher Liddle, Xing‐Mai Jiang, Geoffrey C. Farrell – 1 August 1995 – The effects of bile duct ligation (BDL) on the activity and content of individual hepatic mixed‐function oxidases (MFOs) was examined. Five days after BDL, hepatic microsomal total cytochrome P450 (CYP) content and NADPH‐cytochrome P450‐reductase (P450‐reductase) activity were reduced to 56% and 57% of control, respectively.

Mario Strazzabosco, Carlo Poci, Carlo Spirlì, Akos Zsembery, Anna Granato, Maria Luisa Massimino, Gaetano Crepaldi – 1 August 1995 – Intracellular pH (pHi) plays an important role in the metabolic activation of quiescent cells after a proliferative stimulus, and Na+/H+ exchange activity is required for growth in some extrahepatic tumors.