Energy status in anoxic rat hepatocytes: Effects of isoflurane, solution composition, and hypothermia
Ben J. Howard, Roman Pohorecki, Gerald L. Becker, Dennis F. Landers – 1 July 1995 – Both cold and warm ischemia occur during liver transplantation. Hypothermia and Wisconsin solution preserve adenine nucleotide energy status, which is crucial to hepatic function and viability. The volatile anesthetic isoflurane has been shown to preserve energy status in anoxic isolated hepatocytes in warm Krebs solution. The present study examined isoflurane effects on energy status during incubation also in Wisconsin or Krebs‐plusadenosine solution at 37° or 4°.