Jiezhong Chen, Michael Murray, Christopher Liddle, Xing‐Mai Jiang, Geoffrey C. Farrell – 1 August 1995 – The effects of bile duct ligation (BDL) on the activity and content of individual hepatic mixed‐function oxidases (MFOs) was examined. Five days after BDL, hepatic microsomal total cytochrome P450 (CYP) content and NADPH‐cytochrome P450‐reductase (P450‐reductase) activity were reduced to 56% and 57% of control, respectively.

Mario Strazzabosco, Carlo Poci, Carlo Spirlì, Akos Zsembery, Anna Granato, Maria Luisa Massimino, Gaetano Crepaldi – 1 August 1995 – Intracellular pH (pHi) plays an important role in the metabolic activation of quiescent cells after a proliferative stimulus, and Na+/H+ exchange activity is required for growth in some extrahepatic tumors.

Adrian M. Di Bisceglie – 1 August 1995

Richard Sallie – 1 August 1995 – Objective: To analyze the distribution of hepatitis C virus (HCV) genotypes among patients positive for antibody to HCV (anti‐HCV) according to age, severity of liver disease, and duration of infection; to investigate the influence of HCV genotypes on response to interferon‐α therapy; and to study HCV viremia levels in relation to genotypes and severity of liver disease. Design: Cross‐sectional study. Setting: 3 university hospitals and 2 research units.

Morris Sherman, Kevork M. Peltekian, Cindy Lee – 1 August 1995 – Objective: To prospectively determine the prevalence and annual incidence of hepatocellular carcinoma in hepatitis B carriers in a heterogeneous urban North American population and to assess the diagnostic accuracy of tests used for screening for this cancer. Design: Prospective cohort study of 1,069 chronic carriers of hepatitis B virus using screening with α‐fetoprotein alone or in combination with ultrasonography every 6 months. Results: The mean age of the cohort was 39 ± 12 years (± SD), 65% were men, 71% were Asians.

Maria De Lourdes Ponce, Marcos Rojkind – 1 August 1995 – Laminin belongs to a family of proteins that contains at least seven variants. Together with fibronectin, it is the most important cell‐adhesion protein. Recent data from various laboratories have suggested that liver sinusoidal laminins differ from Engelbert‐Holmes‐Swarm tumor laminin (laminin 1), because the former contain α2 instead of α1 chains. Therefore, we compared the adhesion of hepatocytes to laminin 1 and a matrix extracted with dilute acetic acid from liver biomatrix (LBP).

A. J. Demetris – 1 August 1995

Decherd Stump, Richard A. Weisiger, Paul D. Berk – 1 August 1995 – Long chain fatty acids (LCFAs) are an important energy substrate used by cardiac myocytes and other cells, but the mechanism whereby these molecules cross the plasma membrane is poorly understood. We used an expression cloning strategy and a cDNA library from 3T3‐L1 adipocytes to identify a cDNA that, when expressed in cultured cells, augments uptake of LCFAs.

1 August 1995

Donald R. Taylor, Roger S. Crowther, John C. Cozart, Pamela Sharrock, Jinguang Wu, Roger D. Soloway – 1 August 1995 – This study of sets of cholesterol gallstones collected consecutively from 222 patients in La Paz, Bolivia, and Mexico City, Mexico, has developed a reliable infrared (IR) spectroscopic method for the detection of calcium carbonate in cholesterol gallstones and provided the basis for simultaneous identification of each of its three polymorphs: calcite, vaterite, and aragonite.