Absence of nuclear factor κB inhibition by NSAIDs in hepatocytes

Nuria A. Callejas, Marta Casado, Lisardo Boscá, Paloma Martín‐Sanz – 30 December 2003 – Stimulation of fetal hepatocytes with proinflammatory cytokines and lipopolysaccharide promotes the expression of cyclooxygenase‐2 (COX‐2) and nitric oxide synthase‐2 (NOS‐2), whereas the hepatoma cell line HepG2 exhibits a behavior similar to that described for adult hepatocytes and only expresses NOS‐2.

Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF‐α via the PI 3‐kinase–Akt signaling pathway

Hirofumi Kawanaka, Michael K. Jones, Imre L. Szabo, Dolgor Baatar, Rama Pai, Kouji Tsugawa, Keizo Sugimachi, I. James Sarfeh, Andrzej S. Tarnawski – 30 December 2003 – Activation of endothelial nitric oxide synthase (eNOS) in portal hypertensive (PHT) gastric mucosa leads to hyperdynamic circulation and increased susceptibility to injury. However, the signaling mechanisms for eNOS activation in PHT gastric mucosa and the role of TNF‐α in this signaling remain unknown.

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Michael Fuchs, Boris Ivandic, Oliver Mueller, Carmen Schalla, Juergen Scheibner, Petra Bartsch, Eduard F. Stange – 30 December 2003

Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1–derived reactive oxygen species

Natalia Nieto, Scott L. Friedman, Arthur I. Cederbaum – 30 December 2003 – The alcohol‐inducible cytochrome P450 2E1 (CYP2E1) is expressed mainly in hepatocytes and generates reactive oxygen species (ROS). To better understand how hepatic stellate cells (HSC) become activated in the presence of oxidative stress and evaluate whether CYP2E1‐derived ROS activate stellate cells, we coincubated primary stellate cells with HepG2 cells, which do (E47 cells) or do not (C34 cells) express CYP2E1.

Cis‐preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex

Fritz von Weizsäcker, Josef Köck, Stefan Wieland, Jürgen Beck, Michael Nassal, Hubert E. Blum – 30 December 2003 – Hepadnaviral replication requires the concerted action of the polymerase and core proteins to ensure selective packaging of the RNA pregenome into nucleocapsids. Virus assembly is initiated by cis‐preferential binding of polymerase to the encapsidation signal ϵ, present on pregenomic RNA. Using the duck hepatitis B virus (DHBV) model, we analyzed how core protein is recruited to the RNA/polymerase preassembly complex.

Accuracy of bile duct changes for the diagnosis of chronic liver allograft rejection: Reliability of the 1999 Banff schema

Mylène Sebagh, Karin Blakolmer, Bruno Falissard, Bruno Roche, Jean‐Francois Emile, Henri Bismuth, Didier Samuel, Michel Reynès – 30 December 2003 – Chronic rejection (CR) after liver transplantation is thought to be a dynamic and potentially reversible process. The Banff working group has developed recommendations for its histopathologic staging.

Carcinoembryonic antigen‐related cell adhesion molecule 1 is the 85‐kilodalton pronase‐resistant biliary glycoprotein in the cholesterol crystallization promoting low density protein‐lipid complex

Milan Jirsa, Lucie Muchová, Lubica Dráberová, Petr Dráber, František Šmíd, Masahide Kuroki, Zdenčk Mareček, Albert K. Groen – 30 December 2003 – A pronase resistant 85‐kd glycoprotein in the Concanavalin A–binding fraction (CABF) of biliary glycoproteins has been reported to act as a promotor of cholesterol crystallization. De Bruijn et al. (Gastroenterology 1996;110:1936‐1944) found this protein in a low‐density protein‐lipid complex (LDP) with potent cholesterol crystallization promoting activity. This study identifies and characterizes this protein.

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