Peter R. Flanagan, Attila Hajdu, Paul C. Adams – 1 September 1995 – Iron‐responsive element‐binding protein (IRE‐BP) activity was studied in liver and intestinal samples of hemochromatosis and control patients using a short 32P‐IRE‐RNA probe on “retardation” nondenaturing polyacrylamide gels. IRE‐BP activity was assessed in liver biopsy specimens in 36 patients—16 hemochromatosis homozygotes, 4 hemochromatosis heterozygotes, 6 patients with secondary iron overload, and 10 control patients with normal hepatic iron concentrations.

Dora Ninova, Ruud A. F. Krom, Russell H. Wiesner – 1 September 1995 – Intercellular adhesion molecule‐1 (ICAM‐1) is an adhesion molecule from the immunoglobulin super family that is recognized to be an important factor in the multistep process of cell transendothelial migration and lymphocyte adhesion during antigen recognition and effector cytolysis, mechanisms known to be involved in the pathogenesis of hepatic allograft rejection. A soluble form of ICAM‐1 (sICAM‐1) can be shed into the circulation.

Katherine M. Detre, Manuel Lombardero, Steven Belle, Kimberly Beringer, Timothy Breen, O. Patrick Daily, Nancy L. Ascher – 1 September 1995 – The waiting list for liver transplantation has more than doubled between 1988 and 1992, yet the number of liver transplantations during the same period increased by only 79%. This discrepancy is due to the limited availability of donors. The modest increase in donor pool is caused entirely by donors ≥ 40 years of age, a trend likely to continue.

Maria Antonietta Freni, Domenica Artuso, Guido Gerken, Cesarina Spanti, Teresa Marafioti, Nunziata Alessi, Aldo Spadaro, Antonino Ajello, Oscar Ferrau – 1 August 1995 – Intrahepatic lymphocytic aggregates are observed in chronic hepatitis C as well as in autoimmune chronic hepatitis. Autoantibodies and autoimmune manifestations may occur in hepatitis C. It has been suggested that the lymphocytic aggregates play a role in the liver injury of chronic hepatitis C by an immune‐mediated mechanism.

Joan Saló, Angels Ginès, Luis Anibarro, Wladimiro Jiménez, Ramón Bataller, Joan Clària, Pere Ginès, Francisca Rirvera, Vicente Arroyo, Juan Rodés – 1 August 1995 – It is well known that sodium retention occurs in a significant proportion of patients with cirrhosis despite normal supine plasma levels of renin, aldosterone (ALDO), and norepinephrine (NE). The current study was performed to assess whether this subset of patients also present normal activity of the renin‐aldosterone and sympathetic nervous systems during upright posture in sitting position and moderate physical exercise.

Marc Espeel, Hanna Mandel, Florence Poggi, Jan A. M. Smeitink, Ronald J. A. Wanders, Ingrid Kerckaert, Rudolf B. H. Schutgens, Jean‐Marie Saudubray, Bwee‐Tien Poll‐The, Frank Roels – 1 August 1995 – Peroxisomal deficiency disorders, which are genetically transmitted, are assumed to be expressed in all cells, and the use of cultured skin fibroblasts for diagnosis and research is based on this assumption. We describe three patients with clinical, biochemical, and microscopic evidence of a peroxisomal disorder.

Thuy‐Anh Tran‐Thi, Karl Decker, Patrick A. Baeuerle – 1 August 1995 – Liver macrophages (Kupffer cells) respond to many stimulations with the production of bioactive substances including cytokines, eicosanoids, and inorganic radicals. In this study the activation of transcription factors by substances inducing cytokine gene expression or superoxide formation in rat Kupffer cells was examined.

John B. Watkins – 1 August 1995

Søren Møller, Lars Søndergaard, Jens Møgelvang, Ole Henriksen, Jens H. Henriksen – 1 August 1995 – Whether the central blood volume is reduced or expanded in cirrhosis is still under debate. Accordingly, the current study was undertaken to assess the volume of the heart cavities. Ten cirrhotic patients and matched controls had their right and left ventricular end‐diastolic volumes (RVDV and LVDV), and end‐systolic volumes (RVSV and LVSV) determined by magnetic resonance imaging (MRI). RVDV (122 vs. control 166 mL, P < .02), RVSV (41 vs. 80 mL, P < .02) and right atrial volume (47 vs.

Kofi N. W. Oppong, Kim Bartlett, Christopher O. Record, Hanan Al Mardini – 1 August 1995 – Dysfunction of excitatory glutamatergic neurotransmission has been implicated in the cause of hepatic encephalopathy. Brain microdialysis studies in various animal models of portal systemic encephalopathy (PSE) and encephalopathy associated with acute liver failure, have established that an increase in extracellular glutamate occurs but the mechanisms of this are unclear.