National transplantation pregnancy registry: Analysis of pregnancy outcomes in female liver transplant recipients

John S. Radomski, Michael J. Moritz, Santiago J. Muñoz, Jacqueline R. Cater, Bruce E. Jarrell, Vincent T. Armenti – 1 September 1995 – Outcomes from 48 pregnancies in 34 female liver transplant recipients were analyzed. Data were collected via interviews, questionnaires, and hospital records. All recipients were treated with cyclosporine‐based immunosuppression except 2 patients treated with FK506 and 2 treated with no immunosuppression. The age at conception was 26.1 ± 5.9 years (mean ± SD) with a transplant interval (time from transplantation to conception) of 2.9 ± 2.5 years.

Contribution of true cold and rewarming ischemia times to factors determining outcome after orthotopic liver transplantation

Teerha Piratvisuth, J. Michael Tredger, Karen A. Hayllar, Roger Williams – 1 September 1995 – The role of true cold ischemia times (CIT) and rewarming ischemia times (WIT) in determining outcome after liver transplantation was investigated in 230 adult recipients.

Reversal of atrial natriuretic peptide resistance by increasing distal tubular sodium delivery in patients with decompensated cirrhosis

William T. Abraham, Marije E. Lauwaars, Jin K. Kim, Ricardo L. Peñna, Robert W. Schrier – 1 September 1995 – To test the hypothesis that diminished sodium delivery to the distal tubular site of atrial natriuretic peptide (ANP) action accounts for renal ANP resistance in cirrhosis, 12 cirrhotic patients with ascites were studied at baseline and during the infusion of ANP alone (0.15 μg/kg/min), mannitol alone (4 g/hr), and ANP plus mannitol for 3 hours each.

p53 protein immunoreactivity in extrahepatic bile duct and gallbladder cancer: Correlation with tumor grade and survival

Ioannis Diamantis, Eva Karamitopoulou, Elias Perentes, Arthur Zimmermann – 1 September 1995 – Forty‐five extrahepatic bile duct carcinomas (i.e., tumors of the region proximal to the duct junction, including Klatskin tumors, tumors of the lower mid‐region, and tumors of the ampulla of Vater) and 11 gallbladder carcinomas were immunohistochemically examined for p53 protein expression, using the DO‐7 monoclonal (mAb) and the CM‐1 polyvalent (pAb) antibodies and an antigen retrieval method.

The differential effects of three forms of interferon alfa on hepatic regeneration after partial hepatectomy in the rat

Stephen Wong, Tony Gauthier, Kelly D. E. Kaita, Gerald Y. Minuk – 1 September 1995 – The purpose of this study was to determine whether all commercially available forms of interferon alfa (IFN α) have the same inhibitory effect on hepatic regeneration and whether this inhibitory effect can be prevented by putrescine, a hepatic growth promotor. Adult male Sprague‐Dawley rats (n = 92) received either IFN α‐2a, 2b, n1, or saline, 0 and 8 hours after partial hepatectomy (PHx) or 16 hours before PHx.

Endothelin association with the cultured rat Kupffer cell: Characterization and regulation

Katherine Stephenson, Stephen A. K. Harvey, Shamimunisa B. Mustafa, Ann T. Eakes, Merle S. Olson – 1 September 1995 – Circulating endothelin (ET) levels are elevated in conditions such as endotoxemia, hepatic ischemia‐reperfusion injury, or orthotopic liver transplantation, and this potent peptide may contribute to hepatic pathophysiology. We measured the surface binding of [125I]ET‐1 to rat Kupffer cells in primary culture at 4°C; the apparent dissociation constant (Kd) was 270 pmol/L, and the apparent Bmax was 3,000 receptors/cell.

A fish oil diet minimizes hepatic reperfusion injury in the low‐flow, reflow liver perfusion model

Zhi Zhong, Ronald G. Thurman – 1 September 1995 – In this study, the effects of fish oil treatment on hepatic reperfusion injury in a low‐flow, reflow perfusion model were investigated. Rats were fed powdered diets containing either 5% corn oil or 5% encapsulated fish oil for 13 to 15 days. Average daily food intake in both control and fish oil groups was about 20 g per rat, and weight gain averaged 9 g/rat/d. Livers were perfused at flow rates around 1 mL/g/min for 75 minutes, which caused cells in pericentral regions to become anoxic because of insufficient delivery of oxygen.

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