Syoji Kuroki, Shuichiro Okamoto, Tokio Naito, Hitoshi Oda, Shoji Nagase, Hironori Sakai, Hajime Nawata, Hiroyuki Yamashita, Kazuo Chijiiwa, Masao Tanaka – 1 October 1995 – To examine bile acid synthesis in chronic liver diseases, serum total 7α‐hydroxycholesterol level was measured by gas‐liquid chromatography‐mass spectrometry in patients with cirrhosis (n = 23), patients with chronic hepatitis (n = 21), and control subjects (n = 18). The serum 7α‐hydroxycholesterol levels were significantly lower in patients with cirrhosis than the controls (78 ± 59 pmol/mL vs.

Joann M. Mican, Adrian M. Di Bisceglie, Tse‐Ling Fong, William D. Travis, David E. Kleiner, Bennie Baker, Dean D. Metcalfe – 1 October 1995 – Mastocytosis is a disease of mast cell hyperplasia that may involve several organ systems, including liver. Between 1988 and 1991, we conducted a retrospective‐prospective study of 41 patients with mastocytosis and found 61% had evidence of liver disease.

John F. Renz, Chris L. Mudge, Melvin B. Heyman, Steve Tomlanovich, Ralph P. Kingsford, Barbara J. Moore, John D. Snyder, Hilary A. Perr, Amie L. Paschal, John P. Roberts, Nancy L. Ascher, Jean C. Emond – 1 October 1995 – The purpose of this investigation was to assess the applicability of living‐related liver transplantation in an established regional transplant program by determining the frequency of acceptable living donors from an unselected population of pediatric transplant candidates and identify specific factors limiting application of this technique.

Michael L. Schilsky – 1 October 1995 – The process of hepatobiliary copper (Cu) secretion is still poorly understood Cu secretion as a complex with glutathione and transport via a lysosomal pathway have been proposed. The recent cloning and sequencing of the gene for Wilson disease indicates that Cu transport in liver cells may be mediated by a Cu transporting Ptype ATPase. Biochemical evidence for ATP‐dependent Cu transport in mammalian systems, however, has not been reported so far.

Carl L. Berg – 1 October 1995 – Crigler‐Najjar (CN) disease is classified into two subtypes, type I and II. The molecular basis for the difference between these types is not well understood.

1 October 1995

Francis V. Chisari – 1 October 1995

Masayoshi Yamauchi, Yoshihiko Maezawa, Yuji Mizuhara, Mitsuru Ohata, Junichi Hirakawa, Hisato Nakajima, Gotaro Toda – 1 October 1995 – Alcohol dehydrogenase (ADH), aldehyde dehydrognase (ALDH), and P450IIE1 are the primary enzymes that catalyze the conversion of ethanol to acetaldehyde and then to acetate. Genetic polymorphisms have been reported in ADH2, ADH3, ALDH2, and the 5′‐flanking region of P450IIEI.

1 October 1995

1 October 1995