Evaluation of extracorporeal bioartificial liver devices

Robin D. Hughes, Roger Williams – 1 May 1995 – The initial clinical studies on artificial liver support were performed at King's College Hospital, London during the late 1970s. Initially using charcoal haemoperfusion, and subsequently resin haemoperfusion, and these studies culminated in a controlled clinical trial of charcoal haemoperfusion in which overall survival was high, but no statistically significant benefit was found.

Role of cytoskeleton and acidification of endocytic compartment in asialoglycoprotein metabolism in isolated rat hepatocyte couplets

Masaru Harada, Shotaro Sakisaka, Masao Yoshitake, Masahito Ohishi, Satoshi Itano, Satoshi Shakado, Yoshihiro Mimura, Kazunori Noguchi, Michio Sata, Hiroshi Yoshida, Kyuichi Tanikawa – 1 May 1995 – The process of receptor‐mediated endocytosis is common to a variety of species and cell types. One of the best characterized receptor‐ligand systems is the hepatocyte receptor for asialoglycoproteins. We investigated the morphological features of the uptake and intracellular transport of gold‐conjugated asialofetuin in isolated rat hepatocyte couplets.

Alterations in bile ducts and peribiliary microcirculation in rats after common bile duct ligation

Shu Nakano, Joji Haratake, Hiroshi Hashimoto – 1 May 1995 – The chronological changes in ductular epithelium and peribiliary capillary plexuses (PBPs) after bile duct ligation are not well understood. Therefore, we examined alterations in both intrahepatic bile ductules and peribiliary microcirculation in rats after ligation of the common bile duct using immunohistochemistry, transmission electron microscopes (TEM), and scanning electron microscopes (SEM).

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