Staffan Sahlin, Dagny Ståhlberg, Kurt Einarsson – 1 May 1995 – The objective of this study was to investigate possible pathogenetic factors for cholesterolosis. Liver tissue, gallbladder mucosa, and gallbladder bile were collected in patients with cholesterol gallstones (GS) (14 patients with and 14 patients without cholesterolosis) and gallstone‐free (GSF) subjects (11 with and 21 without cholesterolosis) undergoing cholecystectomy. In cholesterolosis, the gallbladder mucosa was characterized by a fivefold increase in esterified cholesterol and normal content of free cholesterol.

P. Aiden McCormick, Jason Chin, Lynda Greenslade, Stelios Karatapanis, Robert Dick, Neil McIntyre, Andrew K. Burroughs – 1 May 1995 – Octreotide is thought to reduce splanchnic and variceal blood flow with minimal effects on the systemic circulation in cirrhotic patients with portal hypertension. However, we noticed significant bradycardia in some patients immediately after administration of bolus doses of octreotide. Therefore, we investigated the effect of intravenous octreotide on systemic hemodynamics in 59 patients with cirrhosis.

Siddarth Ganguly, Shiv K. Sarin, Vivek Bhatia, Deepak Lahoti – 1 May 1995 – Portal hypertension diffusely affects the gastrointestinal tract. The frequency and profile of distinct colonic mucosal lesions (portal colopathy) and rectal varices (RV; veins >4 cm above the anal verge) is not well studied. Fifty consecutive patients with portal hypertension (25 with cirrhosis, 10 with noncirrhotic portal fibrosis [NCPF], and 15 with extrahepatic portal vein obstruction [EHPVO]) were assessed clinically and by upper and lower gastrointestinal (GI) endoscopy.

Robin D. Hughes, Roger Williams – 1 May 1995 – The initial clinical studies on artificial liver support were performed at King's College Hospital, London during the late 1970s. Initially using charcoal haemoperfusion, and subsequently resin haemoperfusion, and these studies culminated in a controlled clinical trial of charcoal haemoperfusion in which overall survival was high, but no statistically significant benefit was found.

William M. Lee, Willis C. Maddrey – 1 May 1995

Peter J. Friend – 1 May 1995

Masaru Harada, Shotaro Sakisaka, Masao Yoshitake, Masahito Ohishi, Satoshi Itano, Satoshi Shakado, Yoshihiro Mimura, Kazunori Noguchi, Michio Sata, Hiroshi Yoshida, Kyuichi Tanikawa – 1 May 1995 – The process of receptor‐mediated endocytosis is common to a variety of species and cell types. One of the best characterized receptor‐ligand systems is the hepatocyte receptor for asialoglycoproteins. We investigated the morphological features of the uptake and intracellular transport of gold‐conjugated asialofetuin in isolated rat hepatocyte couplets.

Rafael Mañez, Robert H. Kelly, Makoto Kobayashi, Shunichi Takaya, Oscar Bronsther, David Kramer, Rene J. Duquesnoy, Yuichi Iwaki, John J. Fung, Thomas E. Starzl, Anthony J.

Makoto Haramaki, Hirohisa Yano, Kazunori Fukuda, Seiya Momosaki, Sachiko Ogasawara, Masamichi Kojiro – 1 May 1995 – CD44 is a glycosylated cell surface adhesion molecule expressed on a diverse range of cells and has several variant forms, some of which are involved in metastasis of cancer cells.

Raymond S. Koff – 1 May 1995