Harold O. Conn – 1 April 1995

Henkjan J. Verkade, Roel J. Vonk, Folkert Kuipers – 1 April 1995

Eisuke Kawamura, Naoki Yamanaka, Eizo Okamoto, Fumihito Tomoda, Kazutaka Furukawa – 1 April 1995 – This study was designed to investigate the changes in plasma and tissue endothelin‐1/endothelin‐2 (ET) after liver ischemia and to assess the protective effect of anti‐ET 1/ET 2 monoclonal antibody (ET antibody) against ischemia‐reperfusion injury. The ET levels in the liver tissue, hepatic venous blood of the ischemic and non‐ischemic sides, and in the portal venous blood were measured before and after partial liver ischemia for 1 hour in the adult dog.

Wilfred Druml, Wolfgang Hübl, Erich Roth, Herbert Lochs – 1 April 1995 – The impact of hepatic dysfunction on the elimination and hydrolysis of three potential tyrosine sources for total parenteral nutrition, the dipeptides L‐alanyl‐L‐tyrosine (Ala‐Tyr) and glycyl‐L‐tyrosine (Gly‐Tyr), and N‐acetyl‐L‐tyrosine (Nac‐Tyr) were evaluated in six patients with hepatic failure (five chronic, one acute) and seven healthy subjects. In controls, whole‐body clearance (Cltot) of Ala‐Tyr was higher than of Gly‐Tyr (3,169 ± 214 vs.

Alberto Zanella, Dario Conte, Daniele Prati, Fulvio Mozzi, Carmen Capelli, Francesco Zanuso, Mirella Fraquelli, Patrizia Bosoni, Luciana Vianello, Marco Pappalettera, Pietro Velio, Glanguido Montagnolo, Paolo A. Bianchi, Girolamo Sirchia – 1 April 1995 – The clinical significance of single band reactivity (indeterminate pattern) at anti‐hepatitis C virus (HCV) second‐generation recombinant immunoblot assay (RIBA‐2) was investigated in symptomless subjects with normal liver function tests to obtain data for their counseling and clinical management.

1 April 1995

Bernd Dresow, Claudia Albert, Inge Zimmermann, Peter Nielsen – 1 April 1995 – Organ damage caused by iron overload has been mostly attributed to iron‐induced peroxidation of membrane lipids. Using the ferrocene iron—loaded rat model, we studied ethane exhalation as a direct marker of in vivo lipid peroxidation, as well as concentrations of α‐tocopherol and ubiquinol 9/10 in liver and plasma as indirect markers of this process. The feeding of a diet enriched with 0.5% TMH‐ferrocene up to 31 weeks resulted in a large increase in liver iron concentration to about 25 mg/g wet weight (w wt).

Rita Carini, Giorgio Bellomo, Angelo Benedetti, Rosella Fulceri, Alessandra Gamberucci, Maurizio Parola, Mario U. Dianzani, Emanuele Albano – 1 April 1995 – The exposure of isolated hepatocytes to the redox‐cycling quinone menadione caused an early loss of mitochondrial membrane potential, adenosine triphosphate (ATP) depletion, and decreased intracellular pH. These alterations were followed by an increase in intracellular Na+ and, ultimately, cell death.

Parvathi Mohan, Mark Failla, Ian Bremner, Ann Arthur‐Smith, Benny Kerzner – 1 April 1995 – Metallothionein (MT) and glutathione (GSH) have been implicated as two major copper‐binding agents involved in the hepatobiliary copper metabolism in the adult rat. This study was designed to explore their potential role in facilitating copper export from the copper‐laden hepatocyte of the newborn rat. Biliary and hepatic copper, GSH, and immunoreactive MT‐I concentrations were measured in Sprague‐Dawley rats at 1, 2, 3, 4, and 8 weeks of age.

Jorge Quiroga, Bruno Sangro, Marina Núñez, Ignacio Bilbao, Jesús Longo, Luis García‐Villarreal, José M. Zozaya, Maite Betés, José I. Herrero, Jesús Prieto – 1 April 1995 – Seventeen cirrhotics with refractory ascites were treated with transjugular intrahepatic portosystemic shunt (TIPS) and followed for 15.5 ± 3.4 months. Five patients died, four within 3 months after TIPS (hepatocellular failure) and one after 22 months (cholangiocarcinoma). Six patients received transplants 1 to 10 months after the procedure. Actuarial survival at 6, 12, and 24 months was 75%, 75%, and 63%, respectively.