René Romero, Joel E. Lavine – 1 April 1995 – Background: Hereditary tyrosinemia type I is an autosomal recessive inborn error of metabolism caused by a deficiency of the enzyme fumarylacetoacetate hydrolase. The disorder clusters in the Saguenay‐Lac‐St.‐Jean area of Quebec. In this region, 1 of 1846 newborns is affected and 1 of every 22 persons is thought to be a carrier. Recently, we identified a splice mutation and two nonsense mutations in the fumarylacetoacetate hydrolase gene in two patients from Quebec with tyrosinemia type I.

George A. Ellsworthm – 1 April 1995

1 April 1995

Renee C. Lin, Barbara A. Miller, Timothy J. Kelly – 1 April 1995 – Previous studies have shown that plasma levels of high‐density lipoprotein (HDL) cholesterol and the two major protein components of HDLs, i.e., apolipoproteins AI and AII, were elevated in male alcoholic patients without serious liver injury. By contrast, alcohol effect on apolipoprotein E remains unclear. Apolipoprotein E is a major component of very low—density lipoprotein (VLDL) and a minor component of human high‐density lipoprotein.

Lorenzo Polimeno, Alessandro Azzarone, Qui Hua Zeng, Carmine Panella, Vladimir Subbotin, Brian Carr, Boumediene Bouzahzah, Antonio Francavilla, Thomas E. Starzl – 1 April 1995 – The proliferative response of the rat liver was measured after temporary or permanent total biliary obstruction (BDO) and in different regions after selective ligation of the lobar ducts draining the right 60% of the hepatic mass. The results were compared with those after 70% partial hepatectomy (PH).

Tania Roskams, Han Moshage, Rita de Vos, David Guido, Paul Yap, Valeer Desmet – 1 April 1995 – Because increasing evidence implicates heparan sulfate proteoglycans (HSPGs) as essential cofactors in receptor‐growth factor interactions, in cell‐cell recognition systems, and in cell‐matrix adhesion processes and yet little is known about their cellular distribution pattern and cellular sources in liver tissue, we used monoclonal antibodies specific for the core proteins of syndecan1, 2, 3, 4, glypican, and perlecan to investigate their immunohistochemical expression in normal adult human liver

Donna L. Waters, Stuart F. A. Dorney, Margie A. Gruca, Hugh C. O. Martin, Robert Howman‐Giles, Alex E. Kan, Merl de Silva, Kevin J. Gaskin – 1 April 1995 – Focal and multilobular biliary cirrhosis are considered pathognomonic of cystic fibrosis (CF) and almost invariably have been reported in patients with steatorrhea. In contrast, patients with pancreatic sufficiency and normal absorption are considered less likely to develop liver or biliary tract problems.

Scott L. Friedman – 1 April 1995 – Background/Aims: Liver fibrosis and cirrhosis represent common pathological findings in humans with iron overload. This study was undertaken to assess whether in vivo targeting of iron to liver parenchymal or nonparenchymal cells would differently affect collagen gene activity. Methods: Rats were treated with an iron diet or intramuscular injections of iron dextran, and in situhybridization analyses on liver samples were performed. Results: These iron treatments determined parenchymal or reticuloendothelial cell iron overload, respectively.

Brijesh C. Sharma, Rakesh Aggarwal, Subhash R. Naik – 1 April 1995

Marshall J. Orloff, Richard H. Bell, Mark S. Orloff, A. Gerson Greenburg, William G. M. Hardison, J. Michael Henderson, Norman D. Grace – 1 April 1995