Cell proliferation and oncogene expression after bile duct ligation in the rat: Evidence of a specific growth effect on bile duct cells

Lorenzo Polimeno, Alessandro Azzarone, Qui Hua Zeng, Carmine Panella, Vladimir Subbotin, Brian Carr, Boumediene Bouzahzah, Antonio Francavilla, Thomas E. Starzl – 1 April 1995 – The proliferative response of the rat liver was measured after temporary or permanent total biliary obstruction (BDO) and in different regions after selective ligation of the lobar ducts draining the right 60% of the hepatic mass. The results were compared with those after 70% partial hepatectomy (PH).

Concentrations of apolipoproten AI, AII, and E in plasma and lipoprotein fractions of alcoholic patients: Gender differences in the effects of alcohol

Renee C. Lin, Barbara A. Miller, Timothy J. Kelly – 1 April 1995 – Previous studies have shown that plasma levels of high‐density lipoprotein (HDL) cholesterol and the two major protein components of HDLs, i.e., apolipoproteins AI and AII, were elevated in male alcoholic patients without serious liver injury. By contrast, alcohol effect on apolipoprotein E remains unclear. Apolipoprotein E is a major component of very low—density lipoprotein (VLDL) and a minor component of human high‐density lipoprotein.

Walking the ethical highwire: Genetic screening and hereditary tyrosinemia

René Romero, Joel E. Lavine – 1 April 1995 – Background: Hereditary tyrosinemia type I is an autosomal recessive inborn error of metabolism caused by a deficiency of the enzyme fumarylacetoacetate hydrolase. The disorder clusters in the Saguenay‐Lac‐St.‐Jean area of Quebec. In this region, 1 of 1846 newborns is affected and 1 of every 22 persons is thought to be a carrier. Recently, we identified a splice mutation and two nonsense mutations in the fumarylacetoacetate hydrolase gene in two patients from Quebec with tyrosinemia type I.

Chronic ethanol feeding increases the quantity of Gαs‐protein in rat liver plasma membranes

Karen E. Iles, Laura E. Nagy – 1 April 1995 – The liver is a primary target for both acute and chronic effects of ethanol. Because ethanol is known to alter the function of guanine nucleotide regulatory proteins (G‐proteins), changes in hepatic G‐proteins could contribute to the adverse effects of ethanol on liver function. Male Wistar rats were fed a liquid diet containing 36% of calories as ethanol for 4 weeks. Control rats were pair‐fed or allowed free access to a diet that isocalorically substituted maltose dextrins for ethanol.

Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen

Debra L. Laskin, Carol R. Gardner, Veronica F. Price, David J. Jollow – 1 April 1995 – Acetaminophen is a mild analgesic and antipyretic agent that is safe and effective when taken in therapeutic doses. Ingestion of overdoses, however, may lead to acute liver failure accompanied by centrilobular degeneration and necrosis.

Treatment of bleeding from portal hypertensive gastropathy by portacaval shunt

Marshall J. Orloff, Mark S. Orloff, Susan L. Orloff, Kevin S. Haynes – 1 April 1995 – Portal hypertensive gastropathy is a vascular disorder of the gastric mucosa distinguished by ectasia of the mucosal capillaries and submucosal veins without inflammation. During 1988 to 1993, 12 patients with biopsyproven cirrhosis (10 alcoholic, 2 posthepatitic) were evaluated and treated prospectively by portacaval shunt for active bleeding from severe portal hypertensive gastropathy.

T‐cell responses to the components of pyruvate dehydrogenase complex in primary biliary cirrhosis

David E. J. Jones, Jeremy M. Palmer, Oliver F. W. James, Stephen J. Yeaman, Margaret F. Bassendine, Austin G. Diamond – 1 April 1995 – Primary biliary cirrhosis (PBC) is an autoimmune condition that results in destruction of the intrahepatic biliary epithelial cells and is characterized by autoantibodies to pyruvate dehydrogenase complex (PDC).

Subscribe to