Chandan Guha, Motoki Osawa, Phillip A. Werner, Robert M. Galbraith, Gary V. Paddock – 1 June 1995 – Studies were performed in Hep3B hepatocytes to better elucidate the mechanisms regulating circulating levels of human group—specific component (Gc). We measured changes in Gc messenger RNA (mRNA) synthesis and levels of secreted protein resulting from treatment of hepatocytes with cytokines and hormones known to influence synthesis of other proteins of hepatic origin. We particularly focused on compounds known to be prototypic stimulants during the acute phase response.

Poa‐Chun Chang, Cheng‐Po Hu, Shu‐Hsia Chen, Sheng Wang‐Wuu, Chungming Chang – 1 June 1995 – We have previously reported the establishment of well‐differentiated BALB/c mouse liver (ML) cell lines. Transfection of these cell lines with hepatitis B virus (HBV) DNA led to the expression of HBV‐specific antigens and integration of HBV sequences in the cellular genome. Two cloned HBV‐transfected ML cell lines, ML‐2(HBV) and ML‐3(HBV), expressed viral antigens and were highly tumorigenic in nude mice. However, the tumorigenicity of the two cell lines was significantly reduced in BALB/c mice.

Jorg Ziebell, Thomas A. Shaw‐Stiffel, Mitchell L. Shiffman – 1 June 1995

Caryn M. Berkowitz, Cynthia S. Shen, Bahri M. Bilir, Edgardo Guibert, Jorge J. Gumucio – 1 June 1995 – Cholesterol 7α‐hydroxylase, the rate‐limiting enzyme in bile salt synthesis from cholesterol is a P450 enzyme (CYP7A). Its expression and activity are regulated by bile salts, cholesterol, hormones and a circadian modulator. Here we define the hepatocytes contributing to the expression of the rat CYP7A gene during its in vivo circadian variation.

Naeem A. Essani, Michael A. Fisher, Anwar Farhood, Anthony M. Manning, C. Wayne Smith, Hartmut Jaeschke – 1 June 1995 – Neutrophil‐induced liver injury during endotoxemia is dependent on the adhesion molecule Mac‐1 (CD11b/CD18) on neutrophils. The potential involvement of its counterreceptor, intercellular adhesion molecule—1 (ICAM‐1), in the pathogenesis was investigated after administration of 100 μg/kg Salmonella abortus equi endotoxin (ET) in galactosamine‐sensitized mice (Gal).

Satoshi Saitoh, Kenji Ikeda, Isao Koida, Akihito Tsubota, Yasuji Arase, Kazuaki Chayama, Hiromitsu Kumada – 1 June 1995 – We performed serial hemodynamics in 15 patients with 21 well‐differentiated hepatocellular carcinomas. The total length of the observation period ranged from 129 to 678 days (median, 368). We investigated both arterial and portal blood flow at intervals of at least 4 months. Arterial blood flow was measured with carbon dioxide—enhanced ultrasonography (US), and portal blood flow was measured with computed tomographic arterial portography (CTAP).

Naoaki Hashimoto, Tsuyoshi Watanabe, Yasushi Shiratori, Yusei Ikeda, Hirokazu Kato, Katsuken Han, Haruki Yamada, Gotaro Toda, Kiyoshi Kurokawa – 1 June 1995 – We investigated the secretory profiles of prostanoids in two types of nonparenchymal cell from the rat liver, sinusoidal endothelial cells and Kupffer cells, in primary culture both under basal conditions and after stimulation with adenine nucleotides. Prostaglandin (PG) E2 was the main prostanoid secreted by both types of hepatic nonparenchymal cell in the basal and adenosine triphosphate (ATP)‐stimulated states.

Tarun B. Patel, Bipin G. Nair, Ekambaram Padmini, Hani M. Rashed, Hui Sun – 1 June 1995 – Previously, we demonstrated that, 48 hours after partial hepatectomy, in the regenerating liver the number of both atrial natriuretic hormone (ANF) receptor subtypes, the guanylyl cyclase—linked and ANF‐C receptors, is increased twofold. Subsequently, we demonstrated that activation of ANF‐C receptors inhibits growth of hepatocytes.

Michio Morimoto, Ann‐Louise Hagbjörk, Yu‐Jui Yvonne Wan, Paul C. Fu, Paolo Clot, Emanuele Albano, Magnus Ingelman‐Sundberg, Samuel W. French – 1 June 1995 – This study was done to determine if a relationship exists between CYP2E1 induction by ethanol, lipid peroxidation, and liver pathology in experimental alcohol‐induced liver disease in the rat. Rats were fed ethanol with or without diallyl sulfide (DAS) or phenethyl isothiocyanate (PIC) intragastrically for 1 month.

Emanuel K. Manesis, Gregory Giannoulis, Pavlos Zoumboulis, Irini Vafiadou, Stephanos J. Hadziyannis – 1 June 1995 – We tested the hypothesis that a combination of sex hormone suppression and inhibition of their target receptors might improve survival for patients with hepatocellular carcinoma (HCC).