Florence Wong, Laurence Blendis – 1 July 1995

Carlos Guarner, Bruch A. Runyon – 1 July 1995 – Background. Bacterial infection is a frequent and often fatal complication in patients with cirrhosis. Macro‐phages play an important part in the host defense against infection because their Fcγ receptors recognize antibody‐coated bacteria.

Ben J. Howard, Roman Pohorecki, Gerald L. Becker, Dennis F. Landers – 1 July 1995 – Both cold and warm ischemia occur during liver transplantation. Hypothermia and Wisconsin solution preserve adenine nucleotide energy status, which is crucial to hepatic function and viability. The volatile anesthetic isoflurane has been shown to preserve energy status in anoxic isolated hepatocytes in warm Krebs solution. The present study examined isoflurane effects on energy status during incubation also in Wisconsin or Krebs‐plusadenosine solution at 37° or 4°.

K. Sandy Pang, Ford Barker, Andre Simard, Andreas J. Schwab, Carl A. Goresky – 1 July 1995 – Acetaminophen uptake and conversion in the perfused rat liver to acetaminophen sulfate was studied with the multiple indicator dilution technique (MID).

Tetsuya Kiuchi, Ernst R. Kuse, Karl J. Oldhafer, Burckhardt Ringe, Shogo Okamoto, Albrecht Bornscheuer, George Brabant, Yoshio Yamaoka, Rudolf Pichlmayr – 1 June 1995 – Regulatory roles of insulin and glucagon in hepatic metabolism and function are well described. However, little is known about implications of host pancreatic hormones in primary function of grafted liver. This study aimed to investigate it in relation to hepatic mitochondrial function.

Marc Bilodeau, Sébastien J. Provencher, Stéphane Néron, Pierre Haddad, Sylvie Vallières, Marielle Gascon‐Barré – 1 June 1995 – Extreme variations in extracellular Ca2+ concentrations ([Ca2+]e) modify the signaling generated by many hormones and growth factors. However, the influence of physiological changes in [Ca2+]e on the response to hepatic mitogens remains largely unknown.

Parmjeet Randhawa, Anthony J. Demetris, Michael A. Nalesnik, Gerald Niedobitek, Stefan G. Hubscher – 1 June 1995

1 June 1995

Agnes Duflot, Raj Mehrotra, Shun‐Zhang Yu, Luc Barraud, Christian Trepo, Lucyna Cova – 1 June 1995 – The striking difference in the geographical distribution of liver cancer in ducks raised the question of whether duck hepatitis B virus (DHBV), like mammalian hepadnaviruses, could be an oncogenic agent. Hepatocellular carcinomas (HCCs) have been found only in domestic ducks in Qidong, China, where hepatitis B virus infection and aflatoxin B1 (AFB1) are both risk factors and where a high frequency of human HCCs has been reported.

Michel Niederberger, Pere Ginès, Phoebe Tsai, Pierre‐Yves Martin, Kenneth Morris, André Weigert, Ivan McMurtry, Robert W. Schrier – 1 June 1995 – Arterial vasodilation is considered to be the key factor in the development of sodium and water retention leading to ascites formation in cirrhosis. To determine if nitric oxide (NO) is involved in the pathogenesis of arterial vasodilation in cirrhosis, we measured the concentration of cyclic guanosine monophosphate (cGMP), the second messenger of NO, in arterial tissue from rats with carbon tetrachloride—induced cirrhosis.