Immune mechanisms of alcohol‐induced liver disease
Lynell W. Klassen, Dean Tuma, Michael F. Sorrell – 1 July 1995
Pathomorphologic characteristics of small hepatocellular carcinoma: A special reference to small hepatocellular carcinoma with indistinct margins
Osamu Nakashima, Shigetaka Sugihara, Masayoshi Kage, Masamici Kojiro – 1 July 1995 – Some surgically resected small hepatocellular carcinoma (HCC) up to 2 cm in diameter have indistinct margins, and it is sometimes difficult to identify the margins of the cancer nodule in the resected specimen. We classified such tumors as small HCC with indistinct margins and carried out a morphological study to define their characteristics in comparison with small HCC with distinct margins as a control group. We have encountered 27 examples among 86 tumors smaller than 2.0 cm in diameter.
High familial prevalence of gallstones in the first‐degree relatives of gallstone patients
Shiv K. Sarin, Vir S. Negi, Richa Dewan, Smailaja Sasan, Anoop Saraya – 1 July 1995 – Limited information is available on the prevalence of gallstones in the first‐degree relatives of gallstone patients. Three groups of subjects were studied by realtime ultrasound examination: group A, 105 index gallstone patients (male/female; 20:85); group B, 330 first‐degree relatives of index patients; group C, matched controls for group A (n = 105) and group B (n = 330) subjects. Dietary, anthropometric, and biochemical investigations were carried out.
Humoral response to linear B cell epitopes in the amino terminus of the hepatitis C virus envelope glycoprotein gp72 (E2): Role in protective immunity still unknown
Amy J. Weiner – 1 July 1995 – The hypervariable region 1 (HVR1) of the putative second envelope glycoprotein (gp70) of hepatitis C virus (HCV) contains a sequence‐specific immunological B‐cell epitope that induces the production of antibodies restricted to the specific viral isolate, and anti‐HVR1 antibodies are involved in the genetic drift of HVR1 driven by immunoselection (N. Kato, H. Sekiya, Y. Ootsuyama, T. Nakazawa, M. Hijikata, S. Ohkoshi, and K. Shimotohno, J. Virol. 67:3923–3930, 1993).
Elements of graph design. By Stephen M. Kosslyn. 309 pp. New York: Freeman, 1994. $18.95
Raymond S. Koff – 1 July 1995
Surf's up
Byers W. Shaw – 1 July 1995
Defining the role of transjugular intrahepatic portosystemic shunts in the management of portal hypertension
Roger L. Jenkins – 1 July 1995
Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment
Kazuhiko Koizumi, Nobuyuki Enomoto, Masayuki Kurosaki, Takeshi Murakami, Namiki Izumi, Fumiaki Marumo, Chifumi Sato – 1 July 1995 – Hepatitis C virus (HCV) populations in vivo exist as a mixture of heterogeneous viruses called quasispecies, which have variations in the hypervariable region (HVR). However, the relationship between the diversity of HVR quasispecies, the disease stage, or the interferon (IFN) responsiveness remains to be elucidated.
A comparison of the surgical results in patients with hepatitis B versus hepatitis C‐related hepatocellular carcinoma
Kenji Takenaka, Kazuharu Yamamoto, Akinobu Taketomi, Hidetoshi Itasaka, Eisuke Adachi, Ken Shirabe, Takashi Nishizaki, Katsuhiko Yanaga, Keizo Sugimachi – 1 July 1995 – To assess the differences in the surgical results between patients with hepatitis B‐ and hepatitis C‐related hepatocellular carcinoma (HCC), the operative outcomes of 30 patients with hepatitis B surface antigen (HBsAg)‐positive (the B‐HCC group) and 96 patients with hepatitis C antibody (HCVAb)‐positive (the C‐HCC group), who had undergone hepatic resection from 1989 to 1993, were compared.