Akira Nakano, David L. Marks, Pamela S. Tietz, Piet C. De Groen, Nicholas F. Larusso – 1 July 1995 – The turnover rate of an individual protein is a function of the rates of synthesis and loss of that protein. For most intracellular proteins, loss occurs through digestion by lysosomal or cytosolic proteases. Although a significant proportion of hepatic lysosomal enzymes is released from the hepatocyte by excretion into bile, the contribution of biliary excretion to the turnover of hepatic lysosomal enzymes has never been measured.

Yoshiyuki Miwa, Masahiko Kato, Hisataka Moriwaki, Masataka Okuno, Jun'ichi Sugihara, Horoo Ohnishi, Takashi Yoshida, Yasutoshi Muto, Mitsuo Nakayama, Yujiro Morioka, Kouzou Asagi – 1 July 1995 – Branched‐chain amino acids (BCAA) are known to improve hepatic encephalopathy as well as protein malnutrition in cirrhosis. However, such effects in acute hepatic failure (AHF) remain to be elucidated. The current study was conducted to investigate whether BCAA improves protein metabolism in AHF.

Paul J. Winwood, Detlef Schuppan, John P. Iredale, Choudhury A. Kawser, Andrew J. P. Docherty, Michael J. P. Arthur – 1 July 1995 – Release of 92‐kd type IV collagenase/gelatinase, also known as gelatinase B, by inflammatory and tumor cells is increasingly recognized and is believed to facilitate cellular migration across basement membranes. It has been implicated in the pathogenesis of many diseases, but little is known of its cellular origin(s) and function in liver.

Caroline A. Riely, Alexander S. Petrides – 1 July 1995

Matthias Wettstein, Birgitta Noé, Dieter Häussinger – 1 July 1995 – The influence of endotoxin on the hepatic metabolism and elimination of <3>H‐leukotriene C4 (LTC4) and <3>H‐leukotriene E4 was studied in the single‐pass perfused rat liver. Endotoxin (4 mg/kg body mass) was injected intraperitoneally 8 to 10 hours before livers were isolated for perfusion. Tritiated leukotriene C4 and leukotriene E4 (10 nmol/L) were infused for 5 minutes, and metabolites in bile were determined by high‐pressure liquid chromatography.

John J. Fung, Jorge Rakela, Antonio Pinna, Satoru Todo – 1 July 1995

David R. Gretch, Carlos E. Bacchi, Lawrence Corey, Corazon Dela Rosa, Richard R. Lesniewski, Kris Kowdley, Allen Gown, Indra Frank, James D. Perkins, Robert L. Carithers – 1 July 1995 – We report a prospective clinical and virological study of 18 patients undergoing orthotopic liver transplantation, selected because of hepatitis C virus (HCV) RNA positivity before transplantation. Nine of the 18 patients (50%) developed chronic active hepatitis (CAH) in liver allografts during the first year posttransplantation; hepatitis was first observed between 6 and 25 weeks post‐transplantation.

James R. McConnell, Dean L. Antonson, Chin Siong Ong, Wei‐Kom Chu, Ira J. Fox, Thomas G. Heffron, Alan N. Langnas, Byers W. Shaw – 1 July 1995 – Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy (<1>H MRS) to assess brain glutamine (GLN) in five cases of acute liver failure.

Anke Kretz‐Rommel, Urs A. Boelsterli – 1 July 1995 – To evaluate whether hepatocellular protein adducts of the nonsteroidal antiinflammatory drug diclofenac could elicit a specific cell‐mediated or antibody‐dependent immune response that eventually results in liver cell destruction, we developed a murine ex vivo/in vitro mixed lymphocyte hepatocyte culture (MLHC) model. C57BL/6 mice were immunized either with diclofenac conjugated to keyhole limpet hemocyanin (KLH) or with KLH alone.

Anna Mae Diehl, Shi Qi Yang, Ming Yin, Hui Zhi Lin, Steve Nelson, Greg Bagby – 1 July 1995 – Injury‐related cytokines, such as tumor necrosis factor–alpha (TNF), may preserve liver‐specific gene expression during the subsequent regenerative response by modulating the activity of transcription factors, including CCAAT/enhancer binding proteins (C/EBPs), which regulate differentiated gene expression in hepato‐cytes.