Motoh Iwasa, Kazuyoshi Nakamura, Tsuyoshi Nakagawa, Shozo Watanabe, Hiroshi Katoh, Yasutomi Kinosada, Hisato Maeda, Jun Habara, Shiro Suzuki – 1 February 1995 – The noninvasive determination of effective hepatic blood flow, intrahepatic shunted blood flow, intrahepatic shunt index, and total hepatic blood flow was investigated by using the sequential single photon emission computed tomography. This method was performed for a period of 10 minutes following an intravenous injection of 99mTc‐(Sn)‐N‐pyridoxyl‐5‐methyltryptophan and a venous blood sampling.

Barrie P. Bode, Donald L. Kaminski, Wiley W. Souba, Al P. Li – 1 February 1995 – The transport of L‐glutamine was examined in isolated adult and fetal human hepatocytes as well as in the human hepatoma cell lines HepG2 and SK‐Hep. In all cells studied, glutamine uptake was at least 85% Na+‐dependent.

Adrian Fisher, Charles M. Miller – 1 February 1995

Koichi Shimizu, Ryohei Izumi, Toru Ii, Keiichi Muraoka, Tetsuya Inoue, Wataru Fukushima, Koya Sakamoto, Takashi Tani, Tetsuo Hashimoto, Masao Yagi, Itsuo Miyazaki, Akitaka Nonomura – 1 February 1995 – It has been suggested that the number of argyrophilic nucleolar organizer regions (AgNORs) correlates with cellular activity and the aggressiveness of malignancy. The mean number of AgNORs per nucleus may, therefore, be a prognostic factor for hepatocellular carcinoma (HCC). The purpose of this study was to evaluate the prognostic significance of the number of AgNORs in HCC.

Thomas Knittel, Katrin Neubauer, Thomas Armbrust, Giuliano Ramadori – 1 February 1995 – Von Willebrand factor (vWf) is an adhesive glycoprotein known to play an important role in hemostasis and in tissue injury. Because the latter process resembles hepatic fibrogenesis, we studied the tissue distribution of vWf in diseased livers. In normal rat liver vWf was strongly expressed in the vascular endothelium and as small spots or fiber‐like structures in the hepatic parenchyma. During acute liver injury, pronounced staining was observed within the area of necrosis.

Paolo Buonamico, Carlo Sabbá, Guadalupe Garcia‐Tsao, Elsa Berardi, Gianfranco Antonica, Giovanna Ferraioli, Jonathan E. Jensen, Emanuel Lerner, Kenneth J. W. Taylor, Ottavio Albano, Roberto J. Groszmann – 1 January 1995 – The effect of octreotide, a long‐acting synthetic analog of somatostatin, on fasting and postprandial splanchnic hemodynamics was investigated in cirrhotic patients.

Bernard Bouscarel, Robert Nussbaum, Howard Dubner, Hans Fromm – 1 January 1995 – The uptake of ursodeoxycholic acid (UDCA) was studied in isolated hamster hepatocytes. The uptake was rapid and linear up to 60 seconds for each concentration studied. When the uptake rate was plotted against UDCA concentration, the curve was nonlinear, indicating both saturable and nonsaturable uptake mechanisms. The nonsaturable process had a diffusion constant of 0.01 nmol·s–1·g of cell·μmol/L–1.

Yasuhiro Asahina, Namiki Izumi, Nobuyuki Enomoto, Sei Sasaki, Kiyohide Fushimi, Fumiaki Marumo, Chifumi Sato – 1 January 1995 – In patients with liver cirrhosis, impaired water and sodium excretion has been incriminated in the pathogenesis of ascites formation. Increased reabsorption of water in the distal nephron has been shown to play an important role in water retention in cirrhotic rat kidneys. Recently, a complementary DNA (cDNA) for the vasopressin‐regulated water channel (the aquaporin of the apical membrane of the kidney collecting duct [AQP‐CD]) has been cloned.

Raymond S. Koff – 1 January 1995

Michael F. Sorrell, Byers W. Shaw – 1 January 1995