Enrico Silini, Fulvia Bono, Agostino Cividini, Antonella Cerino, Savino Bruno, Sonia Rossi, Giovanni Belloni, Bruno Brugnetti, Emilio Civardi, Laura Salvaneschi, Mario U. Mondelli – 1 February 1995 – Hepatitis C virus (HCV) infection persists for an indefinite length of time in a major proportion of patients, inducing chronic liver lesions that evolve to cirrhosis and hepatocellular carcinoma (HCC) in approximately 20% of cases. We studied HCV viremia and genotypes by reverse transcription–polymerase chain reaction (RT‐PCR) in 341 consecutive anti‐HCV–positive patients.

Hugo O. Jauregui, Claudy J‐P. Mullon, Donna Trenkler, Sharda Naik, Henry Santangini, Philip Press, Thomas E. Muller, Barry A. Solomon – 1 February 1995 – Orthotopic liver transplantation is the only effective form of therapy currently available for patients with fulminant hepatic failure (FHF). The use of an extracorporeal (EC) liver assist device (LAD) may result in improved presurgical clinical management.

Paul J. Thuluvath, David Edwin, Nancy Chang Yue, Cora Devilliers, Sandra Hochman, Andrew Klein – 1 February 1995 – Increased, symmetrical signals of varying intensity in the globus pallidi on T1‐weighted (T1W) images, without corresponding signals on T2‐weighted (T2W) images, have been reported previously in chronic hepatic failure, It has been suggested that these signals are characteristic of chronic hepatic encephalopathy.

A. Jake Demetris, Eric C. Seaberg, Kenneth P. Batts, Linda D. Ferrell, Jurgen Ludwig, Rodney S. Markin, Steven H. Belle, Katherine Detre – 1 February 1995 – Pathologists participating in the National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplant Database (LTD) created a histopathological grading system for acute liver allograft rejection, and tested it first for inter‐ and intra‐rater reliability among a group of five pathologists experienced in liver and transplantation pathology.

Hirokazu Yago, Yutaka Kohgo, Junji Kato, Naoki Watanabe, Sumio Sakamaki, Yoshiro Niitsu – 1 February 1995 – We describe the first evidence that soluble asialoglycoprotein receptors (AGPR) are present in human serum and that they are quantifiable by an enzyme‐linked immunosorbent assay (ELISA). An affinity chromatography gel immobilized with monoclonal antibodies (McAbs) against human liver AGPR was mixed with normal sera, and the bound fraction was analyzed both by sodium dodecyl sulfate polyacrylamide gel electrophoresis and by Western blot analysis.

Jinlin Hou, Peter Karayiannis, Jenny Waters, Kangxian Luo, Chishen Liang, Howard C. Thomas – 1 February 1995 – The presence of unique hepatitis B virus (HBV) variants has been investigated in two Chinese patients with chronic liver disease, whose sera were positive for HBV‐DNA by dot blot hybridization or polymerase chain reaction (PCR) but hepatitis B surface antigen (HBsAg)–negative by conventional polyclonal antibody based immunoassays.

Jürgen Scheibner, Michael Fuchs, Michael Schiemann, Eduard F. Stange – 1 February 1995 – In the current study, the role of the supply of preformed and newly synthesized cholesterol for the feedback control of the synthesis of different bile acids and the secretion of biliary cholesterol was investigated.

Jaap Twisk, Marco F. M. Hoekman, Eline M. Lehmann, Piet Meijer, Willem H. Mager, Hans M. G. Princen – 1 February 1995 – Evidence from in vivo studies indicates that the bile acid pool and bile acid excretion are increased in humans with diabetes mellitus and in experimental diabetic animals, and that both parameters return to normal levels after administration of insulin.

Masato Nagino, Yuji Nimura, Junichi Kamiya, Satoshi Kondo, Katsuhiko Uesaka, Yukoh Kin, Naokazu Hayakawa, Hideo Yamamoto – 1 February 1995 – Changes in lobar volume of the liver and in total hepatic function were studied in 19 patients with biliary tract cancer who underwent right portal vein embolization as preoperative management for extensive liver resection. Computed tomography (CT) was performed to estimate liver volume before and approximately 11 days after embolization. An indocyanine green (ICG) test was performed before and 11 to 13 days after embolization.

David K. Menon, Janet Sargentoni, Simon D. Taylor‐Robinson, Jimmy D. Bell, I. Jane Cox, David J. Bryant, Glyn A. Coults, Keith Rolles, Andrew K. Burroughs, Marsha Y. Margan – 1 February 1995 – Hepatic phosphorus‐31 magnetic resonance spectroscopy (31P MRS) was undertaken in 85 patients with histoloically proven cirrhosis of varying etiologies and functional severity. Reference data were acquired from 16 healthy volunteers who had no history or evidence of liver disease or alcohol abuse.