Hester N. van Wassenaer‐Van Hall, Jeroen van der Grond, Jan van Hattum, Carole Kooijman, Tjaard U. Hoogenraad, Willem P. Th. M. Mali – 1 February 1995 – The goal of this study was to analyze the possibilities of 31P MR spectroscopy to detect abnormal hepatic histological changes in patients with diffuse liver disease. 31P MR spectroscopy was performed, on a 1.5 T whole‐body spectrometer using an image guided localization technique (ISIS), on 38 patients with various diffuse liver diseases, who all underwent histological and serum analysis, and 22 healthy volunteers.

Carmine Panella, Francesco William Guglielmi, Tecla Mastronuzzi, Antonio Francavilla – 1 February 1995 – The aim of this study was to examine and compare whole‐body and segmental impedance measurements in control subjects and patients with progression of liver disease and to investigate whole‐body and segmental bioelectrical changes occurring during dehydration therapy or paracentesis. Males have lower resistance (R) and reactance (Xc) values than females in measurements both of the whole body and of the arm, leg, and trunk. This is not true in patients.

Sonia Navas, Orencio Bosch, Inmaculada Castillo, Eduardo Marriott, Vicente Carreño – 1 February 1995 – Based on the knowledge that patients with porphyria cutanea tarda (PCT) usually have chronic liver disease, several authors studied a possible relationship to hepatotropic virus infections. However, the prevalence of hepatitis B virus (HBV)‐DNA by polymerase chain reaction (PCR) in serum of these patients, as well as the presence of hepatitis C virus (HCV)‐RNA in paired liver, peripheral blood mononuclear cells (PBMCs), and serum samples in these patients has not been reported.

1 February 1995

Kevin D. Mullen, Roger F. Butterworth, John Wells, Gilles Pomier‐Layrargues – 1 February 1995

John M. Levey, Paul L. Romain, Herbert L. Bonkovsky – 1 February 1995 – Background. Essential mixed cryoglobulinemia is frequently associated with hepatitis C virus (HCV) infection. A beneficial effect of interferon alfa therapy has been reported, but we do not know whether the antiviral activity of the drug affects the clinical and biochemical manifestations of disease. Methods. In a prospective randomized, controlled trial, we studied 53 patients with HCV‐associated type II cryoglobulinemia.

Patricia A. Sheiner – 1 February 1995

Sanjay Chanda, Raja S. Mangipudy, Alan Warbritton, Thomas J. Bucci, Harihara M. Mehendale – 1 February 1995 – Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that causes massive centrilobular hepatic necrosis at high doses, leading to death. The objectives of this study were to test our working hypothesis that preplaced cell division and hepatic tissue repair by prior thioacetamide (TA) administration provides protection against APAP‐induced lethality and to investigate the underlying mechanism.

Domenico Alvaro, Antonio Benedetti, Alessandro Gigliozzi, Adriano Bini, Sonia Furfaro, Cristina Bassotti, Tiziana La Rosa, Anne Marie Jezequel, Livio Capocaccia – 1 February 1995 – This study investigated the effect of Brefeldin A (BFA) on the transcytotic vesicular pathway labeled with horseradish peroxidase (HRP) in both isolated rat hepatocyte couplets (IRHC) and the isolated perfused rat liver (IPRL). To evaluate the role of the transcytotic vesicular pathway on bile secretion, the efffect of BFA on bile secretion in the IPRL was then investigated.

Juan G. Mella, Elke Roschmann, Klaus‐Peter Maier, Brigitte A. Volk – 1 February 1995 – The major histocompatibility complex class II alleles at the HLA‐DPB1 locus were investigated in 32 German Caucasoid patients with primary biliary cirrhosis (PBC) and compared with those from 47 normal control patients using molecular genotyping techniques.