Bilirubin conjugate changes in the bile of gallbladders containing gallstones

Carl A. Goresky, Ellen R. Gordon, E. John Hinchey, Gerald M. Fried – 1 February 1995 – Gallbladder bile was obtained at laparoscopic cholcystecotomy from 31 patients with gallstones, and duodenal aspirates from 18 normal controls. Bile pigments (9 conjugates and unconjugated bilirubin) were analyzed by high‐performance liquid chromatography. The average proportional composition of the bile pigments from the patients with gallstones was characteristically different from the controls.

Human immunodeficiency virus infection as risk factor for mother‐to‐child hepatitis C virus transmission; Persistence of anti–hepatitis C virus in children is associated with the mother's anti–hepatitis C virus immunoblotting pattern

Paola Manzini, Giorgio Saracco, Antonella Cerchier, Caterina Riva, Alberto Musso, Emanuela Ricotti, Elvia Palomba, Carlo Scolfaro, Giorgio Verme, Ferruccio Bonino, Pier Angelo Tovo – 1 February 1995 – To determine the rate of vertical transmission of hepatitis C virus (HCV), we prospectively studied 45 babies born to anti‐HCV–positive women with or without con‐comitant infection with the human immunodeficiency virus (HIV).

Predicting survival in fulminant hepatic failure using serum gc protein concentrations

William M. Lee, Robert M. Galbraith, Graeme H. Watt, Robin D. Hughes, Donald D. McIntire, Brenda J. Hoffman, Roger Williams – 1 January 1995 – Plasma Gc protein sequesters actin released into the circulation after massive hepatocyte necrosis, but is greatly depleted in the process. In fulminant hepatic failure (FHF), Gc is present in serum both as a complex with actin and as unbound protein, the latter becoming completely exhausted in those patients with the most severe FHF.

Anti‐liver cytosolic antigen type 1 (LC1) antibodies in childhood autoimmune liver disease

Shuhua Han, Micheal Tredger, Germana V. Gregorio, Giorgina Mieli‐Vergani, Diego Vergani – 1 January 1995 – Antibodies to liver cytosol antigen type 1 (anti‐LC1), which recognize a 60‐kd peptide contained in the liver cytosolic fraction, have been reported to define a subset of autoimmune hepatitis (AIH) either negative for other autoantibodies or positive for anti‐liver kidney microsomal antibody type 1 (LKM‐1) and to be best detected in immunodiffusion.

Hepatitis B virus precore mutant infection is associated with severe recurrent disease after liver transplantation

Peter W. Angus, Stephen A. Locarnini, Geoffrey W. McCaughan, Robert M. Jones, Janine S. McMillan, D. Scott Bowden – 1 January 1995 – The factors that predispose patients undergoing liver transplantation for hepatitis B virus (HBV) disease to severe recurrence of infection are unclear. In this study we examined the effect of pretransplantation infection with HBV and precore variant strains of HBV on posttransplantation outcome and allograft histology in 24 patients who survived more than 3 months after liver transplantation.

Effect of deoxycholate on immunoglobulin G concentration in bile: Studies in humans and pigs

Juan R. Sanabria, Aravinda Upadhya, Brendan Mullen, P. Robert C. Harvey, Steven M. Strasberg – 1 January 1995 – Because an increase in biliary deoxycholate levels seems to be a risk factor for cholesterol gallstone formation, we determined the relationship between deoxycholate levels and levels of the pronucleating protein, immunoglobulin G (Ig) in human gallbladder bile. Patients with cholesterol gallstones had a higher concentration of biliary IgG compared with a pigmented stone group and control patients.

Employment after liver transplantation

Paul C. Adams, Cameron N. Ghent, David R. Grant, William J. Wall – 1 January 1995 – The objective of this study was to study the factors affecting employment after liver transplantation. The employment status and health status of 203 adult liver transplant recipients was assessed retrospectively in a survey comprising an employment questionnaire, the Sickness Impact Profile (SID), and the Medical Outcomes Survey (MOS).

Pediatric liver transplantation for langerhans' cell histiocytosis

Parissa Zandi, Yves Panis, Dominique Debray, Olivier Bernard, Didier Houssin – 1 January 1995 – Langerhans' cell histiocytosis (LCH) represents 15% to 20% of sclerosing cholangitis (SC) in children. In LCH‐associated SC, a very poor response to chemotherapy has been reported, and spontaneous prognosis is very bad. Few cases of orthotopic liver transplantation (OLT) for LCH have been reported and little is known about the risk of recurrence and the effect of immunosuppression after OLT. Since 1986, five children (mean age ± SD, 12.6 ± 3.6 years) underwent OLT for SC complicating LCH.

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