Yves M. Deugnier, Paul Charalambous, Daniéle Le Quilleuc, Bruno Turlin, Jeffrey Searle, Pierre Brissot, Lawrie W. Powell, June W. Halliday – 1 December 1993 – Sublobular nodules of hepatocytes free of iron or exhibiting much less iron than the surrounding parenchyma, referred to in this study as iron‐free‐foci, are frequently found in the livers of patients with genetic hemochromatosis complicated by hepatocellular carcinoma.

1 November 1993

Winita Hardikar, Frederick J. Suchy – 1 November 1993 – Transport systems involved in uptake and biliary secretion of bile salts have been extensively studied in rat liver; however, little is known about these systems in the human liver. In this study, we investigated taurocholate (TC) transport in canalicular and basolateral plasma membrane vesicles isolated from 15 human livers (donor age 6–64 yr). ATP stimulated the uptake of TC into both canalicular and basolateral human liver plasma membrane vesicles (cLPM and bILPM, respectively).

Fred D. Ledley – 1 November 1993

Herman Steen, Hans Smit, Almar Nijholt, Marjolijn Merema, Dirk K. F. Meijer – 1 November 1993 – To investigate whether hepatobiliary transport of organic cations is under regulatory control, we studied transport of tri‐n‐butylmethylammonium in the isolated perfused rat liver and in isolated rat hepatocytes. Transport was investigated in the presence of modulators of the protein kinase C and the cyclic AMP second‐messenger system.

Jose J. G. Marin, Emilio R. Barbero, Maria C. Herrera, Arantxa Tabernero, Maria J. Monte – 1 November 1993 – Liver cell proliferation is a complex process that can be affected by a large number of factors such as bile acids, which have been reported to be associated to the pathogenesis of liver cancer. In this work, bile acid–induced modifications in DNA synthesis by regenerating perfused rat liver were investigated. Two‐thirds hepatectomy was carried out 24 hr before perfusion of livers with recirculating, erythrocyte‐free Krebs‐Henseleit solution.

Robert L. Carithers – 1 November 1993

Roger Lester, Piotr Zimniak – 1 November 1993 – Sodium‐dependent bile acid transport is a well‐established function of the sinusoidal segment of the hepatocyte plasma membrane. Evidence has been provided previously by the authors for the existence of a putative sinusoidal plasma membrane sodium‐dependent bile acid transporter with a mass of 49 kD. This protein has been partially characterized with a monoclonal antibody and by reconstitution in proteoliposomes. Further characterization is provided in the paper under discussion.

Jung‐Min Pak, Samuel S. Lee – 1 November 1993 – To clarify a possible pathogenic role for bile salts in the hyperdynamic circulation of cirrhosis, we studied the vasoactive effects of three different bile salts–tauroursodeoxycholic acid, taurochenodeoxycholic acid and taurodeoxycholic acid–in cirrhotic rats. Cirrhosis was induced with bile duct ligation; controls underwent sham surgery. In vivo, the bile salts were intravenously infused at one of three doses (1.2 × 10−7, 1.2 × 10−6 and 6.0 × 10−5 mol · 100 gm−1 · min−1) for 5 min.

Seiji Kawasaki, Masatoshi Makuuchi, Hidetoshi Matsunami, Yasuhiko Hashikura, Toshihiko Ikegami, Hisanao Chisuwa, Tatsuo Ikeno, Terumasa Noike, Tadatoshi Takayama, Hideo Kawarazaki – 1 November 1993 – Segmental liver volume determination by computed tomographic scan was carried out preoperatively in nine donors for living related liver transplantation. The calculated volume was compared with the graft size actually obtained by three types of donor hepatectomy. The volume of the left lateral segment (175 to 241 ml) and the left lobe (310 to 490 ml) varied markedly among the donors.