Association of primary biliary cirrhosis with human leukocyte antigen DPB1*0501 in Japanese patients

Takeshi Seki, Kendo Kiyosawa, Masao Ota, Seiichi Furuta, Hirofumi Fukushima, Eiji Tanaka, Kaname Yoshizawa, Toshiko Kumagai, Nobuhisa Mizuki, Asako And, Hidetoshi Inok – 1 July 1993 – To investigate the relationship between distribution of human leukocyte antigen alleles and susceptibility to primary biliary cirrhosis among Japanese, we performed serological typing and human leukocyte antigen DP genotyping in 47 Japanese patients with primary biliary cirrhosis.

Unresponsiveness of hepatic nitrogen metabolism to glucagon infusion in patients with cirrhosis: Dependence on liver cell failure

Andrea Fabbri, Giulio Marchesini, Giampaolo Bianchi, Elisabetta Bugianesi, Lucia Bortoluzzi, Marco Zol, Emilio Pis – 1 July 1993 – Glucagon exerts an up‐regulatory effect on hepatic nitrogen metabolism in healthy subjects, but its potential role in the presence of liver failure is uncertain.

Characterization and clinical relevance of liver‐pancreas antibodies in autoimmune hepatitis

Ernst Stechemesser, Reinhild Klein, Peter A. Berg – 1 July 1993 – The isolation of a marker antigen from rat liver and pancreas tissue, which reacts with antibodies in a subtype of autoimmune hepatitis by complement fixation test, enzyme‐linked immunosorbent assay and Western blot, is described. The liver‐pancreas antigen could be detected in tissue from different human or animal organs, but liver and pancreas yielded the highest activity.

Postcholestatic alkaline phosphatase activity after relief of bile duct obstruction in the rat

Ana Maria Wielandt, Margarita Pizarro, Nancy Solis, Marco Arrese, Luigi Accatino – 1 July 1993 – The effects of obstructive cholestasis on the activity of alkaline phosphatase have been extensively studied in serum and liver tissue. However, very little is known about the activity of this enzyme in the postcholestatic condition after relief of the biliary obstruction. The purpose of this study has been to characterize alkaline phosphatase activity in serum, liver and bile in the postcholestatic period and to relate it to changes in bile acid secretory rate.

Decrease of hepatic triglyceride lipase levels and increase of cholesteryl ester transfer protein levels in patients with primary biliary cirrhosis: Relationship to abnormalities in high‐density lipoprotein

Hisatoyo Hiraoka, Shizuya Yamashita, Yuji Matsuzawa, Masaharu Kubo, Shuichi Nozaki, Naohiko Sakai, Ken‐Ichi Hirano, Sumio Kawata, Seiichiro Tarui – 1 July 1993 – Serum levels of high‐density lipoprotein cholesterol are often increased in patients with primary biliary cirrhosis. To elucidate the mechanism of the elevation of high‐density lipoprotein cholesterol levels in this disease, lipoprotein abnormalities were analyzed in 10 patients subdivided into two groups according to concentration of high‐density lipoprotein cholesterol.

Gram‐negative bacterial lipopolysaccharide impairs hyaluronan clearance in vivo and its uptake by the isolated, perfused rat liver

Ion V. Deaciuc, Gregory J. Bagby, Charles H. Lang, Nebojsa Skrepnik, John J. Spitzer – 1 July 1993 – The purpose of this investigation was to examine the effect of gram‐negative bacterial lipopolysaccharide on hyaluronan concentration in blood plasma, hyaluronan removal from the blood and hyaluronan uptake by isolated, perfused rat liver. Intravenous administration of Escherichia coli lipopolysaccharide to rats markedly increased plasma hyaluronan concentration in a dose‐dependent manner.

Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the basis of computed tomography and liver function

Naoki Yamanaka, Eizo Okamoto, Eisuke Kawamura, Toshihiro Kato, Tsuyoshi Oriyama, Jiro Fujimoto, Kazutaka Furukawa, Tsuneo Tanaka, Fumihito Tomoda, Wataru Tanaka – 1 July 1993 – We compared liver volume and function kinetics after partial hepatectomy according to extent of resection and severity of coexisting liver disease in 57 adults with uneventful postoperative courses. Liver volume and massiveness of resection, or resection rate, were estimated on computed tomography.

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