Omeprazole induction of cytochrome P‐450IA2: The importance of selecting the appropriate human model

Paul B. Watkins – 1 April 1993 – Omeprazole has been shown to induce cytochrome P450IA1 and P450IA2 activity in vitro. To reflect cytochrome P450IA2 (CYPIA2) activity in vivo, the 13C‐[N‐3‐methyl]‐caffeine breath test was conducted in 18 volunteers: 12 extensive metabolizers, one intermediate metabolizer, and five poor metabolizers of S‐mephenytoin. Breath tests were performed before treatment with an oral dose of 40 mg omeprazole, on the seventh day of treatment, and after a 7‐day washout period.

Histological evaluation of the intrahepatic biliary tree in intrahepatic cholesterol stones, including immunohistochemical staining against apolipoprotein A‐1

Tetsuo Ohta, Takukazu Nagakawa, Toshiya Takeda, Luis Fonseca, Masahiro Kanno, Kazuhiro Mori, Masato Kayahara, Keiichi Ueno, Itsuo Miyazaki, Tadashi Terada – 1 April 1993 – Apolipoprotein A‐1 is known to be one of inhibiting factors of cholesterol nucleation in bile, and decreased activity of apolipoprotein A‐1 is considered to predispose cholesterol‐supersaturated bile to formation of cholesterol crystals.

A study of oral nutritional support with oxandrolone in malnourished patients with alcoholic hepatitis: Results of a department of veterans affairs cooperative study

Charles L. Mendenhall, Thomas E. Moritz, Gary A. Roselle, Timothy R. Morgan, Bernard A. Nemchausky, Carlo H. Tamburro, Eugene R. Schiff, Craig J. McClain, Luis S. Marsano, John I. Allen, Arun Samanta, Robert E. Weesner, William Henderson, Peter Gartside, Thomas S. Chen, Samuel W. French, Antonio Chedid, Veterans affairs cooperative study group 275 – 1 April 1993 – A Veterans Affairs cooperative study involving 273 male patients was performed to evaluate efficacy of oxandrolone in combination with an enteral food supplement in severe alcoholic hepatitis.

Recombinant interferon‐α in inoperable hepatocellular carcinoma: A randomized controlled trial

Ching‐Lung Lai, Johnson Y. N. Lau, Pui‐Chee Wu, Henry Ngan, Hau‐Tim Chung, Stuart J. Mitchell, Timothy J. Corbett, Anthony W. C. Chow, Hsiang‐Ju Lin – 1 March 1993 – To evaluate the clinical efficacy of interferon‐α in hepatocellular carcinoma, 71 adult Chinese patients with histologically proven inoperable hepatocellular carcinoma were randomized to receive recombinant interferon‐α2a (50 × 106 IU/m2) intramuscularly three times a week (n = 35) or no antitumor therapy (n = 36).

Peroxisomes in cirrhosis of the human liver: A cytochemical, ultrastructural and quantitative study

Dirk De Craemer, Marina Pauwels, Frank Roels – 1 March 1993 – Hepatocellular peroxisomes in 32 patients with cirrhosis were studied by means of catalase cytochemical and morphometric analysis. Seven normal human livers were used as controls. The severity of the cirrhosis was determined with the Child‐Turcotte criteria. Under the light microscope, a decrease in catalase staining was observed in 12 livers. Staining showed a weak inverse correlation with severity of the cirrhotic process. Peroxisomes revealed a perinuclear configuration in 24 patients.

Non‐A, non‐B posttransfusion hepatitis: Comparing C and non‐C hepatitis

Ronald L. Koretz, Maria Brezina, Alan J. Polito, Stella Quan, Judith Wilber, Robert Dinello, Gary Gitnick – 1 March 1993 – Using assays to detect antibodies against antigens (C‐100, 5‐1‐1, C‐22 and C‐33) of the hepatitis C virus, we tested stored sera from 40 patients prospectively identified as having non‐A, non‐B posttransfusion hepatitis. The 28 patients who demonstrated seroconversion (“documented hepatitis C”) had more severe initial disease; all 20 cases of chronic hepatitis occurred in this subgroup.

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