Julián Panés, Josep M. Bordas, Josep M. Piqué, Juan C. García‐pagán, Faust Feu, Josep Terés, Jaime Bosch, Joan Rodés – 1 February 1993 – This study investigated the effects of the short‐term administration of propranolol on gastric blood perfusion in cirrhotic patients with portal hypertensive gastropathy. Portal hypertensive gastropathy is a common cause of nonvariceal bleeding in cirrhosis, which is associated with increased gastric mucosal perfusion and is favorably influenced by propranolol therapy.

1 February 1993

Raymond S. Koff, Elihu M. Schimmel – 1 February 1993

Toru Takahashi, Jerome M. Lasker, Alan S. Rosman, Charles S. Lieber – 1 February 1993 – The propensity of centrilobular liver damage to develop in alcohol abusers after exposure to various hepatotoxins, including ethanol itself, has been linked to the induction by ethanol of P‐4502E1, a microsomal P‐450 enzyme that bioactivates these agents to reactive metabolites.

David Sacerdoti, Massimo Bolognesi, Carlo Merkel, Paolo Angeli, Angelo Gatta – 1 February 1993 – Studies of renal perfusion when kidney function tests are still normal could be useful to understand the pathophysiology of functional kidney impairment in cirrhosis; currently, this requires invasive methodology. Duplex Doppler ultrasonography allows noninvasive evaluation of intrarenal arterial resistances.

Bertram I. Cohen, Shigeo Miki, Erwin H. Mosbach, Nariman Ayyad, Richard J. Stenger, Takahiro Mikami, Michiko Yoshii, Kenji Kihira, Takahiko Hoshita – 1 January 1993 – The prevention of cholesterol gallstone formation by three bile acid analogs, sodium 3α,7α‐dihydroxy‐5β‐cholane‐24‐sulfonate, sodium 3α,7β‐dihydroxy‐5β‐cholane‐24‐sulfonate and sodium 3α, 6α‐dihydroxy‐5β‐cholane‐24‐sulfonate, was examined in a hamster model of cholesterol cholelithiasis. Sodium taurochenodeoxycholate, sodium tauroursodeoxycholate and sodium taurohyodeoxycholate were studied simultaneously for comparison.

Melissa P. Upton – 1 January 1993

Raymond S. Koff, Raymond S. Koff – 1 January 1993

Francesco Violi, Domenico Ferro, Claudio Quintarelli, Antonio Musca, Francesco Balsano, Corrado Cordova, Stefania Basili, The Calc Group – 1 January 1993 – This study explored the relationship between clotting activation and tissue plasminogen activator and its inhibitor in cirrhotic patients with different degrees of liver failure. Sixty‐seven patients (40 men, 27 women; age = 31–77 yr) with cirrhosis diagnosed by liver biopsy were divided into three subgroups (A, B and C) on the basis of Child‐Pugh classification.

Hiroyasu Okuno, Masashi Takasu, Haruhiko Kano, Toshihito Seki, Yasuko Shiozaki, Kyoichi Inoue – 1 January 1993 – The depressant effect of interferon beta on drugmetabolizing activity in the human liver was investigated. Seven patients with chronic hepatitis C were treated with interferon beta at doses of 3 × 106 to 9 × 106 IU/day for 8 wk. The activities of 7‐methoxycoumarin O‐demethylase and 7‐ethoxycoumarin O‐deethylase in specimens obtained by liver biopsy were examined before and after interferon treatment.