Alain Dubois, Michel Dauzat, Christine Pignodel, Gilles Pomier‐Layrargues, Christiane Marty‐Double, François‐Michel Lopez, Charles Janbon – 1 February 1993 – The pathogenesis of portal hypertension in patients with lymphoproliferative and myeloproliferative disorders is not fully understood. We investigated 20 patients with myeloproliferative disease and 47 patients with lymphoproliferative disease.

Glynn Bolitho, Gert Engelbrecht, Zoe Lotz, Marilyn Tyler, Heather McLeod, Kaz Jaskiewicz, Rosemary Hickman – 1 February 1993 – Current knowledge of liver regeneration after reduced liver transplantation is limited. Warm ischemia is one component of the reduced liver transplantation procedure that could have an impact on the regenerative response.

Antoine Hadengue, Didier Lebrec, Richard Moreau, Philippe Sogni, François Durand, Christophe Gaudin, Jacques Bernuau, Jacques Belghiti, Brice Gayet, Serge Erlinger, Jean‐Pierre Benhamou – 1 February 1993 – Portal pressure and portal‐systemic collateral circulation after orthotopic liver transplantation have not been investigated. We studied systemic and splanchnic hemodynamics in 17 patients with cirrhosis before and 205 ± 146 days after orthotopic liver transplantation.

Daphna Fenyves, Louise Gariépy, Jean‐Pierre Villeneuve – 1 February 1993 – To delineate the factors responsible for impaired clearance in cirrhosis, we examined propranolol disposition in rats with carbon tetrachloride–induced cirrhosis and compared it with that in control animals, rats treated with chlorpromazine (an inhibitor of propranolol metabolism) and rats with acute liver injury. We measured the extraction ratio of propranolol by the isolated perfused liver and related it to estimates of propranolol drug‐metabolizing enzyme activity in homogenates of the same livers.

Hui‐Cheng Cheng, Chuen‐May Yang, Ming‐Shi Shiao – 1 February 1993 – Hepatic zonation of cholesterol and glycerolipid synthesis was investigated in regenerating rat livers 24 hr after partial hepatectomy. Tritiated acetate and [U‐14Clglycerol were injected into rats' peritoneal cavities for a short‐term labeling study. Periportal and perivenous hepatocytes were isolated by digitonin collagenase perfusion. Cholesterol synthesis was significantly higher in periportal hepatocytes of the sham‐operated livers (periportal/perivenous = 1.67; p < 0.05).

1 February 1993

Irwin M. Arias, Mingxin Che, Zenaida Gatmaitan, Cynthia Leveille, Toshirou Nishida, Marie St. Pierre – 1 February 1993

Shuichi Terasaki, Yasuni Nakanuma, Masakazu Yamazaki, Masashi Unoura – 1 February 1993 – Eosinophils and their secretory proteins are important in necroinflammatory processes. In this study we surveyed eosinophilic infiltration of the liver in 176 liver biopsy specimens from patients with primary biliary cirrhosis. A considerable number of eosinophils were found in the portal tracts in 51 of these specimens (29%), whereas this finding occurred in only 2 of 50 (4%) specimens from patients with viral chronic active hepatitis. Eosinophilic infiltration of the portal tracts was focal.

Nancy Rolando, Alexander Gimson, Jim Wade, John Philpott‐Howard, Mark Casewell, Roger Williams – 1 February 1993 – To compare the efficacy of a selective parenteral and enteral antimicrobial regimen in patients with fulminant liver failure, we classified 104 patients on reaching grade II encephalopathy as infected or noninfected. Patients who were infected were randomly assigned to receive IV cefuroxime (group 1) or selective parenteral and enteral antimicrobial regimen (group 2).

John A. Hermos – 1 February 1993