Jonathan B. Kruskal, Simon C. Robson, John J. Franks, Ralph E. Kirsch – 1 October 1992 – Patients with liver disease have a variety of coagulation abnormalities. These derangements are of uncertain origin and do not always correlate with disease severity or activity.

Tirso Castillo, Dennis R. Koop, Seiichiro Kamimura, George Triadafilopoulos, Hidekazu Tsukamoto – 1 October 1992 – This study investigated the role of cytochrome P‐450 2E1 in enhanced microsomal lipid peroxidation in experimental alcoholic liver disease. We also examined the contribution of this isoform to the increased microsomal injury in alcoholic liver disease caused by carbon tetrachloride—induced or iron‐induced oxidant stress.

Fa‐Yauh Lee, Agustin Albillos, Luis A. Colombato, Roberto J. Groszmann – 1 October 1992 – This study examined whether an increased activity of the endothelium‐derived relaxing factor, nitric oxide, may account for the hyporesponsiveness to vasoconstrictors in portal hypertension. We performed dose‐response curves to methoxamine, an α‐adrenoceptor agonist, with and without Nω‐nitro‐L‐arginine, a specific inhibitor of nitric oxide synthesis, in experimental portal hypertension.

Ravikumar P. Vemuru, Emma Aragona, Sanjeev Gupta – 1 October 1992 – Assessment of liver regeneration with endogenous genes that are expressed during DNA replication is physiological, specific and direct. To determine whether H3 histone messenger RNA expression (which is tightly coupled with DNA synthesis) could be used for this purpose, we initially examined liver regeneration in a mouse model. After partial hepatectomy, RNA transblot studies showed induction of H3 histone messenger RNA expression in regenerating mouse livers.

Maurizio Parola, Gabriella Leonarduzzi, Fiorella Biasi, Emanuele Albano, Maria E. Biocca, Giuseppe Poli, Mario U. Dianzani – 1 October 1992 – Previous studies have shown that α‐tocopherol (vitamin E) pretreatment of experimental animals can protect against acute liver necrosis induced by carbon tetrachloride. In this study we investigated whether the increase of vitamin E liver content by dietary supplementation influences chronic liver damage and cirrhosis induced by carbon tetrachloride in the rat.

Siria Poucell, William G. M. Hardison, Katsumi Miyai – 1 October 1992 – Experience with young animals, animals administered certain hepatotoxins and animals with two‐thirds hepatectomy suggests that tight junctional permeability is increased in states characterized by architectural remodeling in the liver. In this work we correlate changes in tight junctional morphometry induced by two‐thirds hepatectomy with changes in biliary permeability assessed by sucrose and horseradish peroxidase permeation and by alterations in biliary outputs of anionic and cationic cholephilic probes.

Eugene R. Schiff, Michael F. Sorrell, Paul D. Berk – 1 October 1992

Fernando Corrales, América Giménez, Luis Alvarez, Joan Caballería, María A. Pajares, Hernán Andreu, Albert Parés, José M. Mato, Joan Rodés – 1 October 1992 – Administration of carbon tetrachloride to rats resulted in induction of hepatic fibrosis and a 60% reduction of hepatic S‐adenosylmethionine synthetase activity without producing any significant modification of hepatic levels of S‐adenosylmethionine synthetase messenger RNA. The reduction of S‐adenosylmethionine synthetase activity was corrected by treatment with S‐adenosylmethionine (3 mg/kg/day, intramuscularly).

Raymond S. Koff – 1 October 1992

1 October 1992