Two distinct subtypes of hepatitis C virus defined by antibodies directed to the putative core protein

Atsuhiko Machida, Hitoshi Ohnuma, Fumio Tsuda, Eisuke Munekata, Takeshi Tanaka, Yoshihiro Akahane, Hiroaki Okamoto, Shunji Mishiro – 1 October 1992 – Four distinct genotypes of hepatitis C virus types I, II, III and IV have been identified by comparison of nucleotide sequences of isolates from different areas of the world. We examined the possibility that hepatitis C virus may have serologically definable subtypes. Enzyme‐linked immunosorbent assay systems were prepared by use of two synthetic peptides deduced from the putative core protein of hepatitis C virus.

Monitoring of neurotransmitter amino acids by means of an indwelling cisterna magna catheter: A comparison of two rodent models of fulminant liver failure

Margaret S. Swain, Marcelle Bergeron, Robert Audet, Andres T. Bleiz, Roger F. Butterworth – 1 October 1992 – Alterations of brain and cerebrospinal fluid amino acids have consistently been described in human and experimental fulminant liver failure.

Antimitochondrial antibodies in kindreds of patients with primary biliary cirrhosis: Antimitochondrial antibodies are unique to clinical disease and are absent in asymptomatic family members

Stephen H. Caldwell, Patrick S. C. Leung, James R. Spivey, Thomas Prindiville, Maria de Medina, Theparat Saicheur, Merrill Rowley, K. Rajender Reddy, Ross Coppel, Lennox J. Jeffers, Ian R. MacKay, Eugene R. Schiff, M. Eric Gershwin – 1 October 1992 – The 2‐oxo‐acid dehydrogenase family of enzymes have been identified as the major mitochondrial autoantigens of primary biliary cirrhosis.

Hepatitis C virus RNA and antibody response in the clinical course of acute hepatitis C virus infection

Massimo Puoti, Antonella Zonaro, Antonella Ravaggi, Maria Grazia Marin, Filippo Castelnuovo, Elisabetta Cariani – 1 October 1992 – Hepatitis C virus RNA, anti—hepatitis C virus immune response and biochemical markers of liver injury were investigated in 17 patients with acute non‐A, non‐B hepatitis. At the first observation, 1 to 3 wk from the clinical onset, all patients had hepatitis C virus RNA in their serum, and most (15 of 17) were positive for second‐generation anti—hepatitis C virus enzyme immunoassay. Follow‐up serum samples were available for 10 patients.

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