Papaverine inhibits transcytotic vesicle transport and lipid excretion into bile in isolated perfused rat liver

Tomihiro Hayakawa, Kenji Katagiri, Makoto Hoshino, Tomio Nakai, Takayuki Ohiwa, Tomoyuki Kumai, Makoto Miyaji, Toshihiko Takeuchi, James Corasanti, James L. Boyer – 1 October 1992 – Papaverine is a nonspecific smooth muscle relaxant and a phosphodiesterase inhibitor. Its effects on biliary excretion of lipids and horseradish peroxidase were investigated in a single‐pass isolated perfused rat liver model. A constant infusion of papaverine (1.6 μmol/min; 40 μmol/L) significantly increased bile flow (microliters per minute per gram of liver) before (2.03 ± 0.09 vs.

Evidence for normal nitric oxide—mediated vasodilator tone in conscious rats with cirrhosis

Philippe Sogni, Richard Moreau, Masaru Ohsuga, Stephane Cailmail, Frederic Oberti, Antoine Hadengue, Eric Pussard, Didier Lebrec – 1 October 1992 – Because it has been hypothesized that the hyperkinetic circulation in portal hypertension is the result of increased synthesis of nitric oxide, we compared the hemodynamic effects of nitric oxide synthesis—specific agonist (L‐arginine) and antagonist between normal and cirrhotic conscious rats. The dose‐response curves showed that L‐arginine significantly decreased arterial pressure and increased heart rate.

Prenatal diagnosis of bilirubin‐UDP‐glucuronosyltransferase deficiency in rats by genomic DNA analysis

Tian‐Jun Huang, Jayanta Roy Chowdhury, Pulak Lahiri, Purna C. Yerneni, Vasudeva R. Bommineni, Irwin M. Arias, Namita Roy Chowdhury – 1 September 1992 – Hepatic bilirubin excretion requires UDP‐glucuronosyltransferase–mediated glucuronidation. Patients with type I Crigler‐Najjar syndrome and mutant rats (Gunn strain) inherit deficiency of UDP‐glucuronyltransferase activity toward bilirubin as an autosomal recessive trait and, as a result, exhibit marked nonhemolytic unconjugated hyperbilirubinemia throughout postnatal life.

Hemodynamics during liver transplantation: The interactions between cardiac output and portal venous and hepatic arterial flows

J. Michael Henderson, G. Thomas Gilmore, Gregory J. Mackay, John R. Galloway, Thomas F. Dodson, Michael H. Kutner – 1 September 1992 – Liver blood flow and systemic hemodynamics were measured intraoperatively in 34 patients after liver transplantation. Ultrasound transit‐time flow probes measured hepatic arterial and portal venous flow over 10 to 75 min 1 to 3 hr after reperfusion. Cardiac output was measured by thermodilution. Mean cardiac output was 9.5 ± 2.8 L/min; the mean total liver blood flow of 2,091 ± 932 ml/min was 23% ± 11% of cardiac output.

A pilot study of ribavirin therapy for chronic hepatitis C

Adrian M. di Bisceglie, Michiko Shindo, Tse‐Ling Fong, Michael W. Fried, Mark G. Swain, Nora V. Bergasa, Constantine A. Axiotis, Jeanne G. Waggoner, Yoon Park, Jay H. Hoofnagle – 1 September 1992 – Interferon‐α therapy is of proven efficacy in chronic hepatitis C, but it is not universally effective and may be associated with intolerable side effects. Ribavirin is a nucleoside analog with a broad spectrum of antiviral action. We conducted an uncontrolled pilot study of ribavirin therapy in 13 patients with chronic hepatitis C.

Subscribe to