Frank Iber – 1 September 1992

Ibrahim Kassissia, Colin P. Rose, Carl A. Goresky, Andreas J. Schwab, Glen G. Bach, Suzette Guirguis – 1 September 1992 – We used the multiple‐indicator dilution technique to examine the kinetics of tracer oxygen distribution and uptake in the rat liver perfused in a nonrecirculating fashion with blood. 51Cr‐labeled 18O2‐saturated erythrocytes, labeled albumin, sucrose and water (the tracers for oxygen and vascular, interstitial and cellular references) were injected simultaneously into the portal vein.

Juan Ruiz, Bruno Sangro, José I. Cuende, Oscar Beloqui, JosBé I. Riezu‐Boj, JOSé I. Herrero, Jesús Prieto – 1 September 1992 – The prevalence of hepatitis B and C virus infections was studied in 70 patients diagnosed as having hepatocellular carcinoma. In addition to viral serological markers, serum hepatitis B virus DNA and hepatitis C virus RNA were determined with a nested polymerase chain reaction assay. Twelve patients (17%) were HBsAg positive, 26 (37%) had antibodies to HBs, HBc or both and 32 (46%) were negative for all hepatitis B virus serological markers.

Joseph C. Kolars – 1 September 1992 – Aflatoxin is believed to be a major causative agent in the high incidence of primary liver cancer seen in certain regions of the world. In Fujian Province, an aflatoxin‐endemic region of China, we compared the cigarette smoking habits of 200 primary hepatoma patients with those of 200 matched nonhepatoma controls. We excluded from our study all individuals with evidence of hepatitis B virus serum antigen and/or alcoholic cirrhosis. Interestingly, two groups of hepatoma patients could be discerned.

Jorge J. Gumucio, Rolf Gebhardt – 1 September 1992 – We previously demonstrated that glutamine synthetase (GS) and ornithine aminotransferase (OAT) mRNAs are expressed in the mouse liver acinus preferentially in pericentral hepatocytes, that is, those immediately surrounding terminal central veins (A. L. Bennett, K. E. Paulson, R. E. Miller, and J. E. Darnell, Jr., J. Cell Biol. 105:1073–1085, 1987, and F. C. Kuo, W. L. Hwu, D. Valle, and J. E. Darnell, Jr., Proc. Natl. Acad. Sci. USA, (in press).

Irmin Sternlieb – 1 September 1992 – Three distinct patterns of structural abnormalities of mitochondria, indicated as types I, II and III and associated with steatosis, were identified in the hepatocytes of 40 of 42 asymptomatic and 8 of 22 symptomatic patients with documented Wilson's disease before treatment. No correlation was seen between the type of mitochondrial abnormality and the patient's age, hepatic copper concentration, degree of hepatic steatosis or serum aminotransferase level.

Tilo Andus, Volker Gross, Axel Holstege, Margit Ott, Marlies Weber, Martina David, Harald Gallati, Wolfgang Gerok, Jürgen Schölmerich – 1 September 1992 – Ascites and plasma concentrations of soluble tumor necrosis factor receptors p55 and p75 were measured in a prospective study in 34 patients (35 occasions of ascites) with hepatic (5 infected and 21 uninfected) and malignancy‐related (9) ascites.

1 September 1992

Fuyo Yoshimi, Takeshi Nagao, Sumio Inoue, Nobuhiro Kawano, Tetsuichiro Muto, Toshiaki Gunji, Shin Ohnishi, Michio Imawari – 1 September 1992 – Transcatheter arterial chemoembolization is now widely used in cases of surgically unresectable hepatocellular carcinoma. However, it is unclear whether patients with surgically resectable hepatocellular carcinoma should always be treated with hepatectomy as opposed to transcatheter arterial chemoembolization.

Tohru Utsunomiya, Takashi Matsumata, Eisuke Adachi, Hiroshi Honda, Keizo Sugimachi – 1 September 1992 – To determine the limitations of the latest techniques in preoperative liver imaging for hepatocellular carcinoma, 20 patients with histologically proven intrahepatic metastatic tumors were studied. In 32 masses, we were able to assess the relationship between these intrahepatic metastatic tumors and the findings of preoperative imaging individually. Six intrahepatic metastatic tumors not exceeding 5 mm in diameter were missed in all the imaging examinations.