I. David Shocket – 1 October 1992

Atsuhiko Machida, Hitoshi Ohnuma, Fumio Tsuda, Eisuke Munekata, Takeshi Tanaka, Yoshihiro Akahane, Hiroaki Okamoto, Shunji Mishiro – 1 October 1992 – Four distinct genotypes of hepatitis C virus types I, II, III and IV have been identified by comparison of nucleotide sequences of isolates from different areas of the world. We examined the possibility that hepatitis C virus may have serologically definable subtypes. Enzyme‐linked immunosorbent assay systems were prepared by use of two synthetic peptides deduced from the putative core protein of hepatitis C virus.

José A. Solis‐Herruzo, Amelia Gonzalez‐Gamarra, Gregorio Castellano, Maria Teresa Muñoz‐yagüe – 1 October 1992 – Metabolic clearance rate and half‐time of arginine vasopressin were measured in 43 cirrhotic patients and 10 control subjects. Synthetic arginine vasopressin was infused intravenously at a rate of 500 pg/min/kg of body weight for 75 min.

Valeer J. Desmet – 1 October 1992

1 October 1992

Ruth M. Dixon, Peter W. Angus, Bheeshma Rajagopalan, George K. Radda – 1 October 1992 – Eighteen patients with acetaminophen poisoning were studied with 31P magnetic resonance spectroscopy to measure phosphorus‐containing metabolites in their livers. The concentrations of all magnetic resonance—detectable metabolites fell in parallel with a decrease in the synthetic ability of the liver, indicated by the prothrombin time ratio (international normalized ratio).

Masahide Oshita, Nobuhiro Sato, Harumasa Yoshihara, Yoshiyuki Takei, Taizo Hijioka, Hiroyuki Fukui, Moritaka Goto, Takashi Matsunaga, Toru Kashiwagi, Sunao Kawano, Hideyuki Fusamoto, Takenobu Kamada – 1 October 1992 – The role of microcirculation in the pathogenesis of alcoholic liver injury was investigated in isolated perfused livers from fed rats. Infusion of ethanol into the portal vein at concentrations ranging from 25 to 200 mmol/L increased portal pressure, which is an indicator of hepatic vasoconstriction, in a concentration‐dependent fashion.

Laurence M. Blendis – 1 October 1992 – Background. Controlled trials have yielded inconsistent results with regard to the efficacy of corticosteroids in the treatment of alcoholic hepatitis. Three meta‐analyses suggest that they may be effective in patients with encephalopathy who have severe liver disease.

Kenichi Takayasu, Fumihiko Wakao, Noriyuki Moriyama, Yukio Muramatsu, Susumu Yamazaki, Tomoo Kosuge, Tadatoshi Takayama, Shuichi Okada, Nobuo Okazaki, Masatoshi Makuuchi – 1 October 1992 – Of 270 consecutive patients with hepatocellular carcinoma who underwent surgery, 50 who had recurrence and were subsequently treated with transcatheter arterial embolization were analyzed. The longest interval between surgery and recurrence in the 50 patients who underwent transcatheter arterial embolization was 7 yr.

Olivier Ink, Thierry Martin, Thierry Poynard, Marc Reville, Marie‐Laure Anciaux, Claude Lenoir, Jean‐Luc Marill, Hélène Labadie, Claude Masliah, Daniel Perrin, Jean‐Claude Chaput, Denis Vetter, Claude Eugene, Louis Lebodic, Henri Licht, Jean‐Pierre Etienne – 1 October 1992 – We conducted a prospective, multicenter, randomized trial to compare the efficacy of sclerotherapy plus propranolol with that of propranolol alone in the prevention of recurrent gastroesophageal bleeding in severely cirrhotic patients.