Yoshiyuki Nakatsuji, Akihiro Matsumoto, Eiji Tanaka, Hiroyuki Ogata, Kendo Kiyosawa – 1 August 1992 – Serum samples from 100 patients with non‐A, non‐B hepatitis–related chronic liver disease and 100 patients with hepatitis B–related chronic liver disease were tested by first‐generation and second‐generation enzyme‐linked immunosorbent assays, a second‐generation recombinant immunoblot assay and the nested polymerase chain reaction.

Norifumi Kawada, Natsuo Ueda, Yasuhiro Mizoguchi, Kenzo Kobayashi, Takeyuki Monna, Seiji Morisawa, Kazunori Ishimura, Toshiko Suzuki, Shozo Yamamoto – 1 August 1992 – Rats were treated with heat‐killed Propionibacterium acnes and subsequent injection of a small amount of lipopolysaccharide after 7 days. After 24 hr most of the rats died of massive liver cell necrosis. Nonparenchymal liver cells were isolated from this liver injury model and incubated with arachidonic acid.

John C. Hoefs – 1 August 1992 – The albumin difference or gradient between serum ascites is presumed to be an effective estimate of the colloid osmotic pressure gradient, although this has never been directly demonstrated. The colloid osmotic pressure gradient is controlled by the degree of portal hypertension. Thus the albumin gradient is clinically useful in detecting patients with ascites caused by portal hypertension, although some overlap in such patients' albumin gradients exists compared with those of patients without portal hypertension.

J. Mark Farrant, Derek G. Doherty, Peter T. Donaldson, Robert W. Vaughan, Karen M. Hayllar, Ken I. Welsh, Adrian L. W. F. Eddleston, Roger Williams – 1 August 1992 – Previous studies based on serological HLA phenotyping have implicated genes in the HLA class II region in susceptibility to and protection from primary sclerosing cholangitis. In a recent report, the HLA DRw52a antigen was present in all 29 patients who had been referred for liver transplantation.

Kenneth Devaney, Zachary D. Goodman, Kamal G. Ishak – 1 August 1992 – Giant‐cell hepatitis is a frequent pattern of liver injury in the neonate, but it is rare after infancy. Such cases have been attributed to autoimmune disease, to non‐A, non‐B hepatitis and, most recently, to paramyxovirus infection. To better define the entity of postinfantile (syncytial) giant‐cell hepatitis, we reviewed 24 biopsy specimens from 20 patients with this finding, either alone or in combination with other diagnoses. The number of multinucleated giant cells varied greatly from one specimen to another.

Yasushi Shiratori, Ryo Nakata, Ken'ichi Okano, Yutaka Komatsu, Shuichiro Shiina, Tateo Kawase, Tsuneaki Sugimoto, Masao Omata, Mitsugu Tanaka – 1 August 1992 – This study investigates the role of hepatic asialo GM1–positive cells in inhibiting hepatic metastasis of colon carcinoma (colon adenocarcinoma 38) in mice after administration of a biological response modifier, streptococcal derivative (OK432).

Mauro Bernardi, Claudio de Marco, Franco Trevisani, Carlo de Collibus, Lorenzo Fornalé, Mario Baraldini, Pietro Andreone, Carmela Cursaro, Fabio Zacá, Amedeo Ligabue, Giovanni Gasbarrini – 1 August 1992 – To assess the hemodynamic status of patients with compensated cirrhosis, mean arterial pressure, cardiac index and peripheral vascular resistance and markers of central (plasma concentrations of atrial natriuretic factor) and arterial volemia (plasma norepinephrine concentration, plasma renin activity) were studied in 10 patients and 10 healthy control subjects under steady‐state condition

1 August 1992

Moritaka Goto, Yoshiyuki Takei, Sunao Kawano, Shingo Tsuji, Hiroyuki Fukui, Hiroaki Fushimi, Yoshiya Nishimura, Toru Kashiwagi, Hideyuki Fusamoto, Takenobu Kamada – 1 August 1992 – This study examines whether tumor necrosis factor and endotoxin are involved in the pathogenesis of primary nonfunction of graft and pulmonary complication after orthotopic liver transplantation. Livers from Lewis rats were stored for either 1 or 4 hr in ice‐cold Euro‐Collins solution (1‐hr storage and 4‐hr storage group, respectively). Subsequently, donor livers were implanted orthotopically.

Yuji Tanaka, Norio Hayashi, Akira Kaneko, Toshifumi Ito, Eiji Miyoshi, Yutaka Sasaki, Hideyuki Fusamoto, Takenobu Kamada – 1 August 1992 – Digital imaging fluorescence microscopy has been used to investigate epidermal growth factor–induced calcium responses of fura‐2–loaded hepatocytes in primary culture at the single‐cell level. Epidermal growth factor induced oscillations in cytosolic free calcium ([Ca2+]i) consisting of a periodic train of spikes unlike the monophasic elevation in cell suspensions reported previously.