Masakatsu Uchihara, Namiki Izumi, Chifumi Sato, Fumiaki Marumo – 1 July 1992 – Endothelin is a newly discovered potent vasoconstrictor peptide. To explain the clinical significance of endothelin in patients with chronic liver diseases, we measured the plasma concentration of endothelin in patients with chronic hepatitis (n = 15), cirrhosis with ascites (n = 8) and cirrhosis without ascites (n = 12), and we compared the findings with the plasma concentration of endothelin in normal controls (n = 14).

Andrew Mason, Boris Yoffe, Christine Noonan, Mary Mearns, Carolyn Campbell, Amanda Kelley, Robert P. Perrillo – 1 July 1992 – In this study, peripheral‐blood mononuclear cells from patients with chronic hepatitis B and spontaneous or therapy‐induced disappearance of HBsAg were examined for HBV DNA. Samples were evaluated by in situ hybridization and polymerase chain reaction both before and after clearance of HBsAg.

Frederick Askari, James Wilson – 1 July 1992 – An approach involving retroviral‐mediated gene therapy for the treatment of neoplastic disease is described. This therapeutic approach is called “virus‐directed enzyme/prodrug therapy” (VDEPT). The VDEPT approach exploits the transcriptional differences between normal and neoplastic cells to achieve selective killing of neoplastic cells. We now describe development of the VDEPT approach for the treatment of hepatocellular carcinoma.

Paul K. Vreugdenhil, Diane C. Marsh, Folkert O. Belzer, James H. Southard – 1 July 1992 – We used an isolated‐hepatocyte model to study how hypothermic storage (simulating liver preservation) affects metabolism after prolonged preservation. Rat hepatocytes were stored in the University of Wisconsin solution for up to 72 hr. After each day of storage, protein synthesis, urea synthesis, ATP content and lactate dehydrogenase release were determined in rewarmed (37° C) and oxygenated hepatocytes.

Mordechai Rabinovitz, Judith S. Gavaler, Robert H. Kelly, David H. Van Thiel – 1 July 1992 – Primary hemochromatosis is a genetically determined autosomal recessive disorder characterized by the excessive accumulation of body iron, most of which is deposited in the parenchymal cells of various organs.

Ikuko Motohashi, Masahiko Okudaira, Tomoko Takai, Satoshi Kaneko, Noriaki Ikeda – 1 July 1992 – In an attempt to provide a quantitative basis for differentiation between well‐differentiated hepatocellular carcinoma and hepatocellular carcinomalike lesions (focal nodular hyperplasia, regenerative nodular hyperplasia and hepatocellular adenoma), histopathological and morphometrical analyses were performed on 208 cases of various liver diseases with the aid of an image analyzer.

A. William Paulsen, Goran B. G. Klintmalm – 1 July 1992 – The purpose of this study was to investigate intraoperatively a population of patients with end‐stage liver disease before and after liver transplantation with respect to (a) the range of hepatic and systemic hemodynamics and their changes associated with transplantation and (b) the ability to identify native hemodynamic correlates with specific diagnostic groups. Hepatic artery and portal vein blood flows were determined with square‐wave electromagnetic flowmetry.

Frieder Berr, Edgar Schreiber, Ulrich Frick – 1 July 1992 – The relative amount of cholesterol and the fatty acid composition of phosphatidylcholines in bile can be influenced by the bile acid species secreted.

Dale L. Coy, Phyllis Zee, Andres T. Blei – 1 July 1992

Donald A. Antonioli – 1 July 1992