Interrelationships of bile acid and phospholipid fatty acid species with cholesterol saturation of duodenal bile in health and gallstone disease

Frieder Berr, Edgar Schreiber, Ulrich Frick – 1 July 1992 – The relative amount of cholesterol and the fatty acid composition of phosphatidylcholines in bile can be influenced by the bile acid species secreted.

Biglycan and decorin gene expression in normal and fibrotic rat liver: Cellular localization and regulatory factors

Dieter H. Meyer, Nora Krull, Kevin L. Dreher, Axel M. Gressner – 1 July 1992 – The expression of genes encoding the core proteins of the novel small chondroitin/dermatan sulfate proteoglycans decorin and biglycan was studied in the livers of normal rats and in liver tissue during fibrogenesis induced by prolonged bile‐duct ligation and thioacetamide poisoning. The cell types responsible for the expression of these transcripts and some key regulatory factors were identified. Both biglycan and decorin messenger RNAs were detected in normal liver tissue.

Refractory ascites: Modulation of atrial natriuretic factor unresponsiveness by mannitol

Gilles A. Morali, Sheldon W. Tobe, Karl L. Skorecki, Laurence M. Blendis – 1 July 1992 – We have previously shown that unresponsiveness to atrial natriuretic factor is a marker of the severity of ascites. The tubular mechanisms are unknown, but it seems that increased reabsorption of sodium proximal to the main site of action of atrial natriuretic factor (i.e., the inner medullary collecting duct) plays an important role. We attempted to decrease the proximal reabsorption of sodium with mannitol in patients unresponsive to atrial natriuretic factor.

Fulminant hepatitis related to transmission of hepatitis B variants with precore mutations between spouses

Shigeru Yotsumoto, Mineo Kojima, Isao Shoji, Kayoko Yamamoto, Hiroaki Okamoto, Shunji Mishiro – 1 July 1992 – A precore defective variant of hepatitis B virus has been indicated to cause fulminant hepatitis in various instances such as intrahospital outbreaks or motherto‐child transmission of hepatitis B virus.

Plasma levels of brain natriuretic peptide in patients with cirrhosis

Giorgio La Villa, Roberto Giulio Romanelli, Vincenzo Casini Raggi, Cristina Tosti‐Guerra, Maria Laura De Feo, Fabio Marra, Giacomo Laffi, Paolo Geñtilini – 1 July 1992 – Plasma levels of brain natriuretic peptide, a recently identified cardiac hormone with natriuretic activity, were measured in 11 healthy subjects, 13 cirrhotic patients without ascites, 18 nonazotemic cirrhotic patients with ascites and 6 patients with cirrhosis, ascites and functional kidney failure.

Endotoxins inhibit endocytotic catabolism of low‐density lipoproteins in Hep G2 cells

Wei Liao, Claes‐Henrik Florén – 1 July 1992 – The effects of endotoxins on the uptake and degradation of low‐density lipoproteins in Hep G2, a welldifferentiated human hepatoma cell line, were studied. The results showed that incubation of Hep G2 cells with125I‐labeled low‐density lipoprotein in the presence of endotoxins caused decreased uptake and degradation of125I‐labeled low‐density lipoprotein. The inhibitory effects of endotoxins on the uptake and degradation of125I‐labeled low‐density lipoprotein were dose and time dependent.

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