Glucocorticoid stimulates hepatitis B viral gene expression in cultured human hepatoma cells

Chen‐Kung Chou, Li‐Hsien Wang, Hsing‐Mei Lin, Chin‐Wen Chi – 1 July 1992 – Glucocorticoids have been shown to influence the severity of hepatitis B virus–related chronic hepatitis in human. However, very little is known about the effects of glucocorticoids on hepatitis B virus replication in vitro. In this report, we used a welldifferentiated human hepatoma cell line, Hep3B, transfected with hepatitis B virus complementary DNA as a model to show that a glucocorticoid analog, dexamethasone, can directly stimulate the production of HBsAg and HBeAg.

Ischemic‐type biliary complications after orthotopic liver transplantation

Luis Sanchez‐Urdazpal, Gregory J. Gores, Ellen M. Ward, Timothy P. Maus, H. Erik Wahlstrom, S. Breanndan Moore, Russell H. Wiesner, Ruud A. F. Krom – 1 July 1992 – Nonanastomotic biliary strictures that involve only the biliary tree of the graft occur after orthotopic liver transplantation in patients with hepatic artery thrombosis, chronic ductopenic rejection and ABO blood group incompatibility. This complication may also occur in the absence of these known risk factors.

Prognostic factors in patients with hepatocellular carcinoma receiving systemic chemotherapy

Shuichi Okada, Nobuo Okazaki, Haruhiko Nose, Masayoshi Yoshimori, Kazunori Aoki – 1 July 1992 – A total of 71 consecutive patients with unresectable hepatocellular carcinoma were analyzed retrospectively to determine the significant prognostic factors. All the patients received systemic chemotherapy in a phase 2 study from 1980 to 1990, with no other anticancer treatment. Median survival time and 1‐yr and 2‐yr survival rates were 5.6 mo, 23% and 5%, respectively.

Reversal of fulminant hepatic failure using an extracorporeal liver assist device

Norman L. Sussman, Maria G. Chong, Tarek Koussayer, Da‐Er He, Thomas A. Shang, Hartwell H. Whisennand, James H. Kelly – 1 July 1992 – Liver transplantation is currently the only effective therapy for patients with fulminant hepatic failure. The availability of an artificial liver could bridge these patients through the relatively brief crisis period and allow their own livers to regenerate, providing a more favorable outcome and sparing the trauma and expense of transplant.

Lack of association between cytomegalovirus infection, HLA matching and the vanishing bile duct syndrome after liver transplantation

Carlos V. Paya, Russell H. Wiesner, Paul E. Hermans, Jeffrey J. Larson‐Keller, Duane M. Ilstrup, Ruud A. F. Krom, S. Breanndon Moore, Jurgen Ludwig, Thomas F. Smith – 1 July 1992 – In this study we evaluated the association between cytomegalovirus infection alone or in relation to human leukocyte antigen matching and the development of vanishing bile duct syndrome, a form of chronic hepatic allograft rejection.

A prospective randomized trial comparing repeated endoscopic sclerotherapy and propranolol in decompensated (child class B and C) cirrhotic patients

S. Dasarathy, Manisha Dwivedi, Dinesh K. Bhargava, K. R. Sundaram, K. Ramachandran – 1 July 1992 – A prospective randomized study was conducted to compare the efficacy of long‐term endoscopic sclerotherapy vs. propranolol in Child class B and C patients with variceal bleeds within the 30 days before the study. Forty‐five and 46 patients were randomized to receive sclerotherapy and propranolol, respectively, after preentry stratification for Child scores. Sclerotherapy was administered with 1% polidocanol at 10‐day intervals until obliteration of varices was achieved.

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