1 June 1992

Michiko Shindo, Adrian M. di Bisceglie, Jay H. Hoofnagle – 1 June 1992 – We reanalyzed the results of a pilot study of recombinant α‐interferon therapy for chronic non‐A, non‐B hepatitis in light of the recent discovery of the hepatitis C virus and the development of diagnostic assays for this agent. Stored serum samples from 10 patients treated between 1984 and 1986 were tested for antibody to hepatitis C virus and hepatitis C virus RNA before, during and after therapy.

Julia A. Wendon, Phillip M. Harrison, Richard Keays, Alexander E. Gimsson, Graeme J. M. Alexander, Roger Williams – 1 June 1992 – Hypotension is a serious complication in patients with fulminant hepatic failure, because it is associated with tissue hypoxia and a further compromise to end‐organ function. In this study we investigated the effects of epinephrine and norepinephrine on hemodynamics and oxygen transport variables in 30 patients with fulminant hepatic failure. All had a mean arterial pressure of less than 60 mm Hg, despite adequate intravascular filling pressures.

Lidia L. Ignatenko, Guranda D. Mataradze, Victor B. Rozen – 1 June 1992 – The use of a modified, adequate method of quantification of estrogen receptors has permitted us to prove the existence of sex‐specific peculiarities in rat liver estrogen reception and their significance for the realization of sex‐dependent changes in angiotensinogen plasma level after estrogenization. Endocrine mechanisms for the formation of sex‐related differences in hepatic estrogen receptor content in rats were investigated in detail.

Ji‐Feng Wang, Pavel Komarov, Helmut Sies, Herbert de Groot – 1 June 1992 – Luminol chemiluminescence in phorbolesteractivated cultured rat liver Kupffer cells was strongly inhibited by the selenoorganic compound ebselen (IC50 = 2 μmol/L). Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one) also diminished reduction of ferricytochrome c (IC50 = 10μmol/L), indicating a suppression of superoxide anion formation.

M. Sawkat Anwer – 1 June 1992 – The Ca2+ signal observed in individual fura‐2‐loaded hepatocytes stimulated with the α1‐adrenergic agonist phenylephrine consisted of a variable latency period, a rapid biphasic increase in the cytosolic free Ca2+, followed by a period of maintained elevated cytosolic Ca2+ (plateau phase) that depended on the continued presence of both agonist and external Ca2+, Microinjection of guanosine‐5′‐O‐(3‐thiophosphate) elicited a Ca2+ transient with the same basic features.

Jianye Xu, David Brown, Tim Harrison, Yue Lin, Geoffrey Dusheiko – 1 June 1992 – Precore defective HBV mutants may gradually prevail because of immune selection and explain spontaneous seroconversion from HBeAg to anti‐HBe in HBV carriers. We have analyzed whether the presence of precore HBV mutants is a determinant of responsiveness to interferon‐α therapy. Fifteen carriers (nine responders and six nonresponders)who were treated with interferon‐α were examined. Serum samples were collected before and after therapy.

Tsuneo Kitamura, Joseph Alroy, Zenaida Gatmaitan, Masayasu Inoue, Takashi Mikami, Peter Jansen, Irwin M. Arias – 1 June 1992 – Dubin‐Johnson patients, mutant Corriedale sheep and TR− and EHBR mutant rats have recessively inherited defective bile canalicular secretion of many nonbile acid organic anions. The human and ovine mutants have black livers and lysosomal pigment accumulation. The livers in TR− and EHBR mutant rats are not black, and sparse lysosomal pigment accumulation is seen.

Richard F. McGuire, D. Montgomery Bissell, Janet Boyles, F. Joseph Roll – 1 June 1992 – Open fenestrations are a conspicuous feature of sinusoidal endothelial cells and allow free movement of plasma into the space of Disse. In hepatic fibrosis, the number of fenestrations decreases as interstitial collagen increases in the liver, a change that correlates with deposition of extracellular matrix in the space of Disse.

Joaquin Palma, Humberto Reyes, Jose Ribalta, Joaquin Iglesias, Manuel C. Gonazalez, Ismael Hernandez, Celia Alvarez, Claudina Molina, Ana Maria Danitz – 1 June 1992 – The efficacy and safety of ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy was investigated in an open pilot study. Five patients received 1 gm/day of ursodeoxycholic acid during 20 days and another three patients received two identical periods of treatment separated by a 14‐day interval free of the drug.