Erin G. Schuetz – 1 June 1992 – The extracellular matrix (ECM) promotes tissue morphogenesis, cell migration, and the differentiation of a variety of cell types. However, the mechanisms by which ECM causes differentiated gene expression have been unknown. In this report, we show that culturing the hepatocyte‐derived cell line H2.35 on an ECM gel changes cell morphology and selectively stimulates the transcription of a subset of liver‐specific genes, including serum albumin.

M. Sawkat Anwer, Paul D. Berk, Frederick J. Suchy, Allan W. Wolkoff – 1 June 1992

Stefano Brillanti, Caterina Masci, Piero Ricci, Mario Miglioli, Luigi Barbara – 1 June 1992 – We assessed the correlation between the positivity for serum IgM antibody to hepatitis C virus and the activity of liver disease in patients with chronic hepatitis C virus infection.

Victor L. Fox – 1 June 1992

Bradford Waters, Caroline A. Riely – 1 June 1992

Kenneth S. Zaret – 1 June 1992 – We have identified the liver‐regulating protein (LRP), a cell surface protein involved in the maintenance of hepatocyte differentiation when cocultured with rat liver epithelial cells (RLEC). LRP was defined by immunoreactivity to a monoclonal antibody (mAb L8) prepared from RLEC. mAb L8 specifically detected two polypeptides of 85 and 73 kD in immunoprecipitation of both hepatocyte‐ and RLEC‐iodinated plasma membranes.

Stefan Krähenbühl, Sonja Krähenbühl‐Glauser, Jörg Stucki, Peter Gehr, Jürg Reichen – 1 June 1992 – Mitochondrial and cytosolic functions were studied in vivo and in perfused livers from rats with secondary biliary cirrhosis induced by bile duct ligation for 5 wk and in sham‐operated controls. The livers were stereo‐logically analyzed, and mitochondrial and cytosolic functions were related to liver structure. Oxygen consumption by perfused livers expressed per stereo‐logically determined mitochondrial volume was decreased by 49% in bile duct—ligated rats compared with control rats.

William J. Sandborn, George M. Lawson, Ruud A. F. Krom, Russell H. Wiesner – 1 June 1992 – This study compares the hepatic‐tissue cyclosporine concentrations in liver biopsy specimens from patients with and without cellular rejection after orthotopic liver transplantation. Nine patients without cellular rejection were studied, including five patients receiving intravenous cyclosporine who had biopsies on posttransplant day 7 and four patients receiving oral cyclosporine who had biopsies on day 21.

Graham L. Kaye, P. Aiden McCormick, Sebastiano Siringo, Kenneth E. F. Hobbs, Neil McIntyre, Andrew K. Burroughs – 1 June 1992 – Esophageal staple transection effectively controls acute variceal bleeding, but up to 50% of these patients will have recurrent upper gastrointestinal bleeding. In our experience, most of these bleeding episodes are caused by total or partial circumferential ulceration at the level of the staple transection: staple line erosion. It caused rebleeding in 29 (40%) of our patients.

Annick Bingen, Jean‐Pierre Martin, François Klein, Marcia Pessah – 1 June 1992 – A mouse hepatitis virus‐3 strain subcultured in our laboratory is a unique experimental model in which to study virus‐induced liver steatosis. This strain produces massive lipid deposition not only in sensitive adult BALB/c mice but also (though less extensive) in virus‐resistant adult A/J mice.