Aziz Ghahary, Gerald Y. Minuk, Jiangming Luo, Tony Gauthier, Liam J. Murphy – 1 June 1992 – Insulinlike growth factor binding proteins modulate the action of the insulinlike growth factors in various bioassays and may regulate the bioavailability of the insulinlike growth factors in vivo. Because the insulinlike growth factors may influence hepatic regeneration, we have examined the effect of partial hepatectomy on serum insulinlike growth factor binding proteins and on the abundance of insulinlike growth factor binding protein‐1 messenger RNA in the liver.

Giuseppe Mazzella, Paolo Parini, Davide Festi, Franco Bazzoli, Rita Aldini, Aldo Roda, Domenica Tonelli, Antonio Cipolla, Antonio Salzetta, Enrico Roda – 1 June 1992 – It has been recently shown that the newest hypocholesterolemic agent, simvastatin, lowers the biliary cholesterol saturation index and that its association with ursodeoxycholic acid renders it more effective.

Masataka Kato, Robin D. Hughes, Richard T. Keays, Roger Williams – 1 June 1992 – Cerebral edema is a serious complication of the encephalopathy in fulminant hepatic failure. It is a major cause of death. The mechanisms responsible for its formation are unclear, and the aim of this study was to investigate the ultrastructural appearance of brain capillaries by scanning electron microscopy.

Erin G. Schuetz – 1 June 1992 – The extracellular matrix (ECM) promotes tissue morphogenesis, cell migration, and the differentiation of a variety of cell types. However, the mechanisms by which ECM causes differentiated gene expression have been unknown. In this report, we show that culturing the hepatocyte‐derived cell line H2.35 on an ECM gel changes cell morphology and selectively stimulates the transcription of a subset of liver‐specific genes, including serum albumin.

M. Sawkat Anwer, Paul D. Berk, Frederick J. Suchy, Allan W. Wolkoff – 1 June 1992

Stefano Brillanti, Caterina Masci, Piero Ricci, Mario Miglioli, Luigi Barbara – 1 June 1992 – We assessed the correlation between the positivity for serum IgM antibody to hepatitis C virus and the activity of liver disease in patients with chronic hepatitis C virus infection.

Victor L. Fox – 1 June 1992

Bradford Waters, Caroline A. Riely – 1 June 1992

Kenneth S. Zaret – 1 June 1992 – We have identified the liver‐regulating protein (LRP), a cell surface protein involved in the maintenance of hepatocyte differentiation when cocultured with rat liver epithelial cells (RLEC). LRP was defined by immunoreactivity to a monoclonal antibody (mAb L8) prepared from RLEC. mAb L8 specifically detected two polypeptides of 85 and 73 kD in immunoprecipitation of both hepatocyte‐ and RLEC‐iodinated plasma membranes.

Stefan Krähenbühl, Sonja Krähenbühl‐Glauser, Jörg Stucki, Peter Gehr, Jürg Reichen – 1 June 1992 – Mitochondrial and cytosolic functions were studied in vivo and in perfused livers from rats with secondary biliary cirrhosis induced by bile duct ligation for 5 wk and in sham‐operated controls. The livers were stereo‐logically analyzed, and mitochondrial and cytosolic functions were related to liver structure. Oxygen consumption by perfused livers expressed per stereo‐logically determined mitochondrial volume was decreased by 49% in bile duct—ligated rats compared with control rats.