1 December 1991

C. Scott Boyer, Dennis R. Petersen – 1 December 1991 – The biochemical mechanism of cocaine hepatotoxicity is thought to involve enzymatic formation of reactive metabolites. The exact hepatocellular effects of these metabolites have yet to be established. This study was designed to monitor, in a time course after an acute cocaine dose, biochemical parameters that are important in cellular defense and homeostasis in vivo.

Jorge Quiroga, Inmaculada Colina, A. Jake Demetris, Thomas E. Starzl, David H. van Thiel – 1 December 1991 – The cause and timing of first liver allograft failure was evaluated in 177 patients who underwent a second liver transplant between January 1984 and December 1988. The population studied consisted of 94 men and 83 women with a mean age 41.3 ± 1.0 yr (mean ± S.E.M.). Mean first‐graft survival was 130.6 ± 22.9 days (range = 0 to 2,073 days).

Solange Bresson‐Hadni, Mireille Rossel, Estelle Seilles, Dominique‐Angéle Vuitton, Khadija Guennoune, Bernard Hory, Jean‐Philippe Miguet, Michel Gillet, Claude Vincent, Jean‐Pierre Revillard – 1 December 1991 – Secretory component was assayed in serum and bile from 34 patients within 40 days after a first or a second (three cases) liver transplantation.

Howard J. Worman, Jean‐Claude Courvalin – 1 December 1991

Joji Haratake, Masanori Hisaoka, Akiko Furuta, Akio Horie, Osamu Yamamoto – 1 December 1991 – Hepatic microcirculation in the developing stages is not fully clarified. This study aimed at clarifying the development of hepatic microcirculation, especially peribiliary vascular plexuses, in neonatal rats by corrosion cast procedures and scanning electron microscopy. Peribiliary vascular plexuses of large bile ducts at the hilus of 1‐day‐old rats showed a simple capillary network that directly poured into the portal vein.

Peter D. Siersema, René P. van Helvoirt, Diane A. M. Ketelaars, Maud I. Cleton, Wim C. de Bruijn, J. H. Paul Wilson, Henk G. van Eijk – 1 December 1991 – Hexachlorobenzene‐induced porphyria is iron dependent and characterized by the decreased activity of uroporphyrinogen decarboxylase and the accumulation of porphyrins in the liver. To examine the relationship between iron and porphyrins in liver tissue, we performed a biochemical and morphological (histological, ultrastructural and morphometrical) study in the livers of C57BL/10 mice.

Russell E. Cowan, Barry T. Jackson, Stephen L. Grainger, Richard P. H. Thompson – 1 December 1991 – The cause of postoperative liver dysfunction is often unclear, but a decrease in liver blood flow during anesthesia and/or major surgery may be important. Plasma half‐life and clearance of indocyanine green were therefore measured in 42 patients before, during and after anesthesia and abdominal surgery. In 13 patients, liver blood flow was also estimated from indocyanine green extraction using hepatic vein catheterization.

Christian Moesch, Denis Sautereau, Franclois Cessot, Pascal Berry, Marcelle Mounier, Alain Gainant, Bernard Pillegand – 1 December 1991 – The deposits obstructing 12 biliary endoprostheses were examined by scanning electron microscopy and analyzed quantitatively by Fourier transform infrared spectroscopy. Calcium palmitate and bilirubinate associated with proteins were found in all the deposits. Apart from the small amount of cholesterol, this composition closely resembled that of brown pigment gallstones and suggested an infectious cause.

Johnson Y. N. Lau, Vincent G. Bain, Nikolai V. Naoumov, Heather M. Smith, Graeme J. M. Alexander, Roger Williams – 1 December 1991 – Interferon‐α has been shown recently to selectively enhance hepatocyte expression of HBsAg/pre‐S2 in chronic hepatitis B virus infection in a way that may enhance immune recognition.