Joan M. Salmerón, Luis Ruiz Del Arbol, Angels Ginès, Joan C. García‐Pagán, Pere Ginés, Faust Feu, Joan Claria, Francisca Rivera, Jaume Bosch, Vicente Arroyo, Joan Rodés – 1 May 1993 – The aim of this study was to assess the effects of an oral dose (20 mg) of isosorbide‐5‐mononitrate on systemic hemodynamics, kidney function, plasma renin activity and plasma aldosterone and atrial natriuretic peptide concentrations in 16 nonazotemic cirrhotic patients.

Wei Liao, Claes‐Henrik Florén – 1 May 1993 – Tumor necrosis factor mediates most biological activities of endotoxin and also, in part, mediates endotoxin‐induced disturbances in lipid metabolism. In this study, the effect of tumor necrosis factor on low‐density lipoprotein receptor activity was investigated in cells of HepG2, a well‐differentiated human hepatoma cell line. Pretreatment of the cells with tumor necrosis factor leads to enhanced binding, uptake and degradation of 125I‐labeled low‐density lipoprotein. This effect of tumor necrosis factor was dose and time dependent.

Krzysztof Krawczynski – 1 May 1993

Thomas Judge – 1 May 1993 – We have previously reported data from clinical and laboratory animal observations which suggest that organ tolerance after transplantation depends on a state of balanced lymphodendritic cell chimerism between the host and donor graft. We have sought further evidence to support this hypothesis by investigating HLA‐mismatched liver allograft recipients.

John D. Lutton, Margaret O. Griffin, Miki Nishimura, Richard D. Levere, Attallah Kappas, Nader G. Abraham, Shigeki Shibahara – 1 May 1993 – Exposure of Hep3B cells to metalloporphyrins (tinprotoporphyrin and heme) or cobalt chloride resulted in the production of a significant number of heme oxygenase transcripts, erythropoietin transcripts or both, as indicated by in situ hybridization.

Nicole Domingo, Huguette Lafont, Zamir Halpern, Yohanan Peled, Jean Grosclaude, Tuvia Gilat – 1 May 1993 – With the demonstration of pronucleating and antinucleating proteins, the role of biliary proteins became of considerable research interest. Anionic polypeptide fraction is the third most abundant biliary protein; it is found in association with biliary lipids, has antinucleating properties for calcium and is found in gallstones. Its levels in various human biles have not been studied as of this writing.

Albert Maroto, Pere Ginés, Vicente Arroyo, Angels Ginés, Joan Saló, Joan Clária, Wladimiro Jiménez, Concepció Bru, Francisca Rivera, Joan Rodés – 1 May 1993 – Brachial artery and common femoral artery blood flows and cardiac output were measured with duplex‐Doppler ultrasonography in 12 normal subjects, 12 patients with compensated cirrhosis and 35 patients with cirrhosis and ascites (8 with functional kidney failure). The aim of this study was to investigate whether arteriolar vasodilation in these vascular territories contributes to hyperdynamic circulation in cirrhosis.

Darrell H. G. Crawford, June W. Halliday, Kim M. Summers, Michael J. Bourke, Lawrie W. Powell – 1 May 1993 – Phenotypic concordance between siblings has been demonstrated in some inherited conditions, and such data provide strong evidence that the severity of disease is affected by genetic factors. We assessed the concordance of liver iron stores between siblings in 22 sibling pairs (15 same‐sex pairs and 7 opposite‐sex pairs) with genetic hemochromatosis.

Hideki Hagiwara, Norio Hayashi, Eiji Mita, Masafumi Naito, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada – 1 April 1993 – We describe a method for quantifying hepatitis C virus RNA in serum. This competitive assay combines reverse transcription and polymerase chain reaction and is based on coamplification of the target RNA with known amounts of synthetic mutated RNA.

Mar Decastro, Javier Sánchez, Jesús F. Herrera, Asunción Cháves, Rafael Durán, Luisa García ‐Buey, Carmelo García‐Monzón, Julia Sequí, Ricardo Moreno‐Otero – 1 April 1993 – The recent identification of the hepatitis C virus and development of assays to detect antibodies to hepatitis C virus has allowed assessment of the prevalence of hepatitis C virus infection in patients with a variety of liver and other diseases. The aim of this study was to investigate the prevalence of hepatitis C virus antibodies and severity of liver injury in patients with porphyria cutanea tarda.