Sun‐Mee Lee, Mark G. Clemens – 1 February 1992 – This study was done to determine the relationship between microsomal lipid peroxidation during hepatic ischemia/reperfusion and alteration in cytochrome P‐450–dependent drug metabolism. Rats were pretreated with α‐tocopherol to inhibit lipid peroxidation or with vehicle (soybean oil) and then subjected to 60 min no‐flow hepatic ischemia in vivo. Control animals were time‐matched sham‐ischemic animals. After 1, 5 or 24 hr of reperfusion, liver microsomes were isolated and cytochrome P‐450 and mixed function oxidases were studied.

David E. Milov, Wou‐Seok Jou, Rachel B. Shireman, Paul W. Chun – 1 February 1992 – Bile salts are potent inhibitors of bovine carbonic anhydrase and human carbonic anhydrase I and human carbonic anhydrase II. To further characterize the binding of bile salts to carbonic anhydrase, rate constants for the CO2 hydration reaction in the presence of deoxycholate, cholate, glycocholate and taurocholate were determined using stop‐flow experments.

James H. Kelly, Tarek Koussayer, Da‐Er He, Maria G. Chong, Thomas A. Shang, Hartwell H. Whisennand, Norman L. Sussman – 1 February 1992 – We have established an improved model of fulminant hepatic failure in dogs. Buthionine sulfoximine is used to inactivate glutathione synthesis, and small increments of acetaminophen are given intravenously to maintain the plasma level at approximately 200 μg/ml for 20 hr. This regimen produces severe liver injury along with many of the features seen in humans with acetaminophen poisoning. The first sign of impending liver failure is hypoglycemia.

Joan Clària, Wladimiro Jiménez, Josefa Ros, Mónica Asbert, Anna Castro, Vicente Arroyo, Francisca Rivera, Joan Rodés – 1 February 1992 – Nitric oxide is a vasodilator tonically secreted by endothelial cells that is involved in the regulation of arteriolar tone. This study, which includes two protocols, was performed to investigate whether nitric oxide plays a role in the pathogenesis of arterial hypotension in cirrhosis with ascites.

Nicolas Argy – 1 February 1992

Luis Sanchez‐Urdazpal, Albert J. Czaja, Bart van Hoek, Ruud A. F. Krom, Russell H. Wiesner – 1 February 1992 – To identify prognostic features and to define the role of liver transplantation in severe autoimmune chronic active hepatitis, findings before and after corticosteroid therapy in 111 patients were correlated with outcome and compared with the findings in 24 patients who had been selected independently for liver transplantation. Patients whose condition deteriorated during corticosteroid treatment were younger (32 ± 3 yr vs.

Harvey J. Alter – 1 February 1992

Jorge J. Gumucio, Thomas F. Imperiale, Arthur J. McCullough – 1 February 1992 – Background. The value of beta‐adrenergic‐antagonist drug therapy for the prevention of initial episodes of gastrointestinal bleeding in patients with cirrhosis and esophageal varices is uncertain, both positive and negative study results having been reported.

Lennox J. Jeffers, Fuad Hasan, Maria de Medina, Rajender Reddy, Talley Parker, Marcelo Silva, Leonardo Mendez, Eugene R. Schiff, Michael Manns, Michael Houghton, Qui‐Lim Choo, George Kuo – 1 February 1992 – Many cases of chronic hepatitis and cirrhosis cannot be attributed to a known cause and are collectively referred to as cryptogenic chronic liver disease. We have evaluated the role of the hepatitis C virus in the pathogenesis of this condition in a retrospective serum analysis for antibody to hepatitis C virus in 129 patients with cryptogenic liver disease.

Claude Degott, Gérard Feldmann, Dominique Larrey, Anne‐Marie Durand‐Schneider, Didier Grange, Jean‐Pierre Machayekhi, Alain Moreau, François Potet, Jean‐Pierre Benhamou – 1 February 1992 – Drug‐induced acute hepatitis may be followed by prolonged cholestasis despite the withdrawal of the drug. Eight patients suffering from prolonged cholestasis caused by several drugs were investigated with sequential liver biopsies.