Luis A. Colombato, Agustin Albillos, Roberto J. Groszmann – 1 February 1992 – Peripheral vasodilatation and plasma volume expansion are required to generate the hyperdynamic circulatory state observed in portal hypertension.

Shimon Reif, Donald Sykes, Thomas Rossi, Milton M. Weiser – 1 February 1992 – The expression of laminin and type IV collagen messenger RNA in rat liver was investigated in relation to liver development. Levels of messenger RNA for laminin chains A, B1 and B2, and α1 and α2 chains of type IV collagen were studied by Northern‐blot and dot‐blot analysis. Although the expression of messenger RNAs for laminin B1 and B2 chains was higher in 19‐day gestational fetal liver when compared with the adult, the highest level was detected in 15‐day newborns.

Kenneth D. R. Setchell, Patrizia Bragetti, Linda Zimmer‐Nechemias, Cynthia Daugherty, Maria Antonietta Pelli, Renato Vaccaro, Giorgio Gentili, Eleonora Distrutti, Giuliano Dozzini, Antonio Morelli, Carlo Clerici – 1 February 1992 – The cerebrohepatorenal syndrome of Zellweger is a congenital syndrome of multiple manifestations, including hepatomegaly and liver dysfunction. Treatment is generally of a supportive nature, aimed at improving nutrition and growth, controlling the central nervous system symptoms and limiting progression of liver disease.

C. R. Wolf, N. K. Spurr, Daniel W. Nebert – 1 February 1992

Theresa C. Peterson, Richard A. Isbrucker – 1 February 1992 – Fibroproliferation was measured as the uptake of [3H]thymidine into fibroblasts. Human fibroblasts were incubated with 200 μl monocyte‐conditioned medium, the 0.22 μm filtrate from cultured monocytes, in Dulbecco's modified Eagle medium supplemented with controlled process serum replacement 2, a fetal calf serum substitute with low mitogenic activity. Increasing the numbers of fibroblasts resulted in a parallel increase in thymidine uptake to a maximal level.

1 February 1992

Raymond S. Koff, Kevin D. Mullen – 1 February 1992

Alan M. Schuller, Harold O. Conn – 1 February 1992

1 February 1992

Shiv K. Sarin, Anupam Bansal, Shailja Sasan, Aruna Nigam – 1 February 1992 – The portal vein is the main source of blood and hepatotrophic factors to the liver. Partial portal‐vein ligation in rats results in reduced growth compared with that in control rats. To investigate whether extrahepatic portal vein obstruction occurring in early childhood influences growth in humans, anthropometric and nutritional assessments were prospectively carried out in 61 patients with extrahepatic portal vein obstruction.