Notices
1 March 1992
Percutaneous transjugular portosystemic shunt: Commentary on the technical aspects of this new procedure
M. Victoria Marx, David Williams – 1 March 1992
“Cuts both ways”: Collagenases, lipocyte activation and polyunsaturated lecithin
Scott L. Friedman – 1 March 1992
Metabolic and hemodynamic responses of bivascularly perfused rat liver to nerve stimulation, noradrenaline, acetylcholine and glucagon in thioacetamide‐induced micronodular cirrhosis
Thomas Zimmermann, Andreas Gardemann, Georg Machnik, Rolf Dargel, Kurt Jungermann – 1 March 1992 – Thioacetamide‐induced rat cirrhosis was characterized by single‐cell necroses, fibrosis, nodular parenchyma, decrease in parenchymal volume density and an increase in liver weight per body weight so that the total amount of parenchyma was not altered. The glycogen content was normal, and signs of decompensation were not found.
Correction
1 March 1992
Portosystemic shunt without surgery
Grace H. Elta, Frederic E. Eckhauser – 1 March 1992 – Objective. – To determine the effectiveness of the Palmaz balloon expandable stent for the creation of a transjugular intrahepatic portosystemic shunt. The device is designed to achieve portal decompression in patients with variceal hemorrhage secondary to portal hypertension.
Hepatic tissue oxygenation as a predictive indicator of ischemia‐reperfusion liver injury
Moritaka Goto, Sunao Kawano, Harumasa Yoshihara, Yoshiyuki Takei, Taizo Hijioka, Hiroyuki Fukui, Takashi Matsunaga, Masahide Oshita, Toru Kashiwagi, Hideyuki Fusamoto, Takenobu Kamada, Nobuhiro Sato – 1 March 1992 – The purpose of this study was to determine whether hepatic tissue oxygenation after ischemia‐reperfusion procedures is an indicator for later liver injury. Partial ischemia in the liver was induced by ligating the left pedicles. Rats were divided into two groups according to duration of ischemia: group A (30‐min ischemia) and group B (60–min ischemia).
Immunohistochemical study of extracellular matrix in acute galactosamine hepatitis in rats
A. Mieke Jonker, Freke W. J. Dijkhuis, Adriana Boes, Machiel J. Hardonk, Joris Grond – 1 March 1992 – A single injection of D‐galactosamine hydrochloride induces acute self‐limiting liver disease in rats that morphologically resembles drug‐induced hepatitis in human beings. In this immunohistochemical study we examined the localization and expression of the hepatic extracellular matrix components fibronectin, laminin, collagen type I, collagen type III and collagen type IV and of the cell surface receptors (integrins) for fibronectin and laminin.
Ultrastructural and immunohistochemical studies of the intrahepatic peribiliary capillary plexus in normal livers and extrahepatic biliary obstruction in human beings
Naoko Kono, Yasuni Nakanuma – 1 March 1992 – Ultrastructural and immunohistochemical study was conducted on the intrahepatic peribiliary capillary plexus in normal livers and in those with extrahepatic biliary obstruction. In both conditions, capillaries positive for Ulex europaeus agglutinin I and type IV collagen were always present in the vicinity of the bile ducts. Immunoelectron microscopy showed the presence of type IV collagen on the basal lamina of these capillaries; Ulex europaeus agglutinin I was also positive on their cytoplasms.
Polyunsaturated lecithin prevents acetaldehyde‐mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes
Jianjun Li, Cho‐Il Kim, Maria A. Leo, Ki M. Mak, Marcos Rojkind, Charles S. Lieber – 1 March 1992 – We recently found that polyunsaturated lecithin prevents ethanol from causing cirrhosis in the baboon. Because transformation of lipocytes to transitional cells plays a key role in hepatic fibrogenesis in vivo, and because this process in alcohol‐fed baboons was found to be attenuated by polyunsaturated lecithin, we focused on lipocytes to study the mechanism of the protective effect.