Francesco Violi, Domenico Ferro, Stefania Basili, Claudio Quintarelli, Mirella Saliola, Cesare Alessandri, Corrado Cordova, Francesco Balsano – 1 April 1992 – Sixty‐one patients with different degrees of liver failure, 23 with Child‐Pugh class B and 38 with Child‐Pugh class C, were studied and observed for 3 yr. Coagulation index analysis showed significantly lower values of prothrombin activity, more prolonged activated partial thromboplastin time, higher bilirubin and fibrinogen degradation products values in class C patients.

Raymond S. Koff – 1 April 1992

Beryl A. Koblin, Patricia E. Taylor, Pablo Rubinstein, Cladd E. Stevens – 1 April 1992 – This study examined the effect of duration of hepatitis B virus infection on the association between human immunodeficiency virus type‐1 infection and hepatitis B viral replication. Twenty‐five chronic HBsAg carriers were studied.

Paolo Angeli, Erica De Bei, Manuela Dalla Pria, Lorenza Caregaro, Giulio Ceolotto, Grazia Albino, Angelo Gatta – 1 April 1992 – The reliability of lithium clearance as an index of distal fluid delivery in cirrhosis with ascites and in other clinical conditions characterized by low fractional sodium excretion has not yet been proven. In particular, lithium reabsorption in the amiloridesensitive segment of the distal tubule, as evidenced in experimental studies, has not been excluded in such clinical conditions.

Kenji Abe, Genevieve Inchauspe, Toshio Shikata, Alfred M. Prince – 1 April 1992 – The relationship between hepatitis C virus RNA and hepatitis C virus‐associated antibodies (antibody against the putative capsid protein and C‐100 antibody) was determined by nested polymerase chain reaction and enzyme‐linked immunosorbent assay in serial serum samples obtained from eight chimpanzees experimentally infected with hepatitis C virus.

Lucian Saucan, George E. Palade – 1 April 1992 – We carried out a comparative investigation on the effects of colchicine (25 μmoles/100 gm body wt) on the intracellular transport, processing and discharge by secretion or proteolytic processing of a membrane protein (i.e., the polymeric IgA receptor) and a secretory protein (i.e., albumin) in rat hepatocytes.

Daryl Daugherty – 1 April 1992 – The nucleotide sequence of the RNA genome of the human hepatitis C virus (HCV) has been determined from overlapping cDNA clones. The sequence (9379 nucleotides) has a single large open reading frame that could encode a viral polyprotein precursor of 3011 amino acids. While there is little overall amino acid and nucleotide sequence homology with other viruses, the 5′ HCV nucleotide sequence upstream of this large open reading frame has substantial similarity to the 5′ termini of pestiviral genomes.

Ulrich Beuers, Ulrich Spengler, Franz M. Zwiebel, Juergen Pauletzki, Sven Fischer, Gustav Paumgartner – 1 April 1992 – Beneficial effects of ursodeoxycholic acid in chronic cholestatic liver diseases have been attributed to displacement of hydrophobic bile acids from the endogenous bile acid pool.

Claudia Martins Da Costa, Dianne Baldwin, Bernard Portmann, Yvette Lolin, Alex P. Mowat, Giorgina Mieli‐Vergani – 1 April 1992 – To investigate the diagnostic value of 24‐hr urinarycopper excretion testing after penicillamine challenge in the diagnosis of Wilson's disease, 75 consecutive children referred for a variety of liver problems and in whom parameters of copper metabolism had been investigated were analyzed retrospectively.

Giovanna Fattovich, Patrizia Farci, Massimo Rugge, Lucio Brollo, Antonella Mandas, Patrizia Pontisso, Giuliano Giustina, M. Eliana Lai, Fabio Belussi, Graziella Busatto, Angelo Balestrieri, Arturo Ruol, Alfredo Alberti – 1 April 1992 – Ongoing hepatitis B virus replication in the presence of antibody to HBeAg can be observed in patients with active liver disease. These forms of chronic hepatitis B have been described as having a poor prognosis.