Christopher Liddle, Michael Hollands, J. Miles Little, Geoffrey C. Farrell – 1 April 1992 – In both rats and humans, partial hepatectomy results in a substantial increase in serum estradiol concentrations. Because mammalian liver of both sexes contains estrogen receptor, it has been suggested that this surge in serum estrogen concentration may initiate or facilitate liver regeneration.
Mario Chojkier, Kenji Fujiwara, Itsuro Ogata – 1 April 1992
Robertson D. Davenport – 1 April 1992 – Prophylactic transfusions of fresh frozen plasma and platelets are sometimes given to patients with mild elevations in prothrombin time (PT) and partial thromboplastin time (PTF) and mild thrombocytopenia before percutaneous liver biopsy. To determine whether PTs and PTFs 1.1–1.5 times midrange normal levels and platelet counts 50–99 × 109/L are associated with increased bleeding complications, hospital records of all patients who underwent percutaneous liver biopsy during 56 consecutive months (n = 291) were reviewed.
James B. Burgess, Jacques U. Baenziger, William R. Brown – 1 April 1992 – Serum concentrations of asialoglycoproteins are increased in cirrhosis. We hypothesized that this increase results from abnormalities in the asialoglycoprotein receptor, which is located on the sinusoidal and lateral membrane of hepatocytes. Therefore we searched for morphological alterations in the distribution of the asialoglycoprotein receptor in human liver, using a light microscopic immunoperoxidase method in autopsy livers.
Giovanna Fattovich, Patrizia Farci, Massimo Rugge, Lucio Brollo, Antonella Mandas, Patrizia Pontisso, Giuliano Giustina, M. Eliana Lai, Fabio Belussi, Graziella Busatto, Angelo Balestrieri, Arturo Ruol, Alfredo Alberti – 1 April 1992 – Ongoing hepatitis B virus replication in the presence of antibody to HBeAg can be observed in patients with active liver disease. These forms of chronic hepatitis B have been described as having a poor prognosis.
Claudia Martins Da Costa, Dianne Baldwin, Bernard Portmann, Yvette Lolin, Alex P. Mowat, Giorgina Mieli‐Vergani – 1 April 1992 – To investigate the diagnostic value of 24‐hr urinarycopper excretion testing after penicillamine challenge in the diagnosis of Wilson's disease, 75 consecutive children referred for a variety of liver problems and in whom parameters of copper metabolism had been investigated were analyzed retrospectively.
Ulrich Beuers, Ulrich Spengler, Franz M. Zwiebel, Juergen Pauletzki, Sven Fischer, Gustav Paumgartner – 1 April 1992 – Beneficial effects of ursodeoxycholic acid in chronic cholestatic liver diseases have been attributed to displacement of hydrophobic bile acids from the endogenous bile acid pool.
Daryl Daugherty – 1 April 1992 – The nucleotide sequence of the RNA genome of the human hepatitis C virus (HCV) has been determined from overlapping cDNA clones. The sequence (9379 nucleotides) has a single large open reading frame that could encode a viral polyprotein precursor of 3011 amino acids. While there is little overall amino acid and nucleotide sequence homology with other viruses, the 5′ HCV nucleotide sequence upstream of this large open reading frame has substantial similarity to the 5′ termini of pestiviral genomes.