James D. Yarbrough, Jo M. Grimley, Jaideep V. Thottassery – 1 May 1992 – The organochlorine compound mirex (dodecachlorooctahydro‐1,3,4‐metheno‐2H‐cyclobuta‐CD‐pentalene) induces an adaptive liver growth dependent on the hormonal status of the experimental animal. In the intact laboratory rat, mirex induces liver growth that is an expression of both cellular hyperplasia and hypertrophy. However, in rats subjected to adrenalectomy, mirex induces liver growth that is essentially hyperplastic.

Kunio Okuda – 1 May 1992

Piter J. Bosma, Namita Roy Chowdhury, Bart G. Goldhoorn, Martin H. Hofker, Ronald P. J. Oude Elferink, Peter L. M. Jansen, Jayanta Roy Chowdhury – 1 May 1992 – Crigler‐Najjar syndrome, type I is a heterogeneous disorder that may result from mutations of various regions of the bilirubin‐UDP‐glucuronosyltransferase gene complex that encodes two bilirubin‐UDP‐glucuronosyltransferase isoforms and a phenol‐UDP‐glucuronosyltransferase isoform in the human liver.

Dieter Jüngst, Thomas Lang, Christoph von Ritter, Ekkehard Pratschke, Gustav Paumgartner – 1 May 1992 – Patients with multiple cholesterol gallbladder stones have been found to be at a higher risk for the recurrence of gallstones after successful nonsurgical treatment than those with a solitary stone. Cholesterol gallstone recurrence, like primary gallstone formation, probably involves a triple defect with supersaturation, abnormally rapid nucleation of cholesterol in bile and altered gallbladder motor function.

Antoine Hadengue, Richard Moreau, Christophe Gaudin, Yannick Bacq, Bruno Champigneulle, Didier Lebrec – 1 May 1992 – Although arterial vasodilation is a well‐known feature in patients with cirrhosis, the venous system remains unexplored. To measure total effective vascular compliance, a reflection of the properties of the venous system, rapid volume expansion (300 ml of a gelatin solution in 3 min) was performed in 23 patients. Eleven patients had compensated cirrhosis (Child‐Pugh grade A or B), and eight had decompensated cirrhosis (Child‐Pugh grade C).

Ann Duthie, Derek G. Doherty, Carolyn Williams, Robert Scott‐Jupp, J. O. Warner, M. Stuart Tanner, Robert Williamson, Alex P. Mowat – 1 April 1992 – Genetic factors have been implicated in the pathogenesis of liver disease in cystic fibrosis. To investigate whether liver disease is associated with particular mutations of the defective gene in cystic fibrosis, we have determined the frequencies of three mutations – ΔF508, G551D and R553X – in 111 children and young adults with cystic fibrosis by analysis of genomic DNA segments amplified by the polymerase chain reaction.

Francesco Violi, Domenico Ferro, Stefania Basili, Claudio Quintarelli, Mirella Saliola, Cesare Alessandri, Corrado Cordova, Francesco Balsano – 1 April 1992 – Sixty‐one patients with different degrees of liver failure, 23 with Child‐Pugh class B and 38 with Child‐Pugh class C, were studied and observed for 3 yr. Coagulation index analysis showed significantly lower values of prothrombin activity, more prolonged activated partial thromboplastin time, higher bilirubin and fibrinogen degradation products values in class C patients.

Raymond S. Koff – 1 April 1992

Beryl A. Koblin, Patricia E. Taylor, Pablo Rubinstein, Cladd E. Stevens – 1 April 1992 – This study examined the effect of duration of hepatitis B virus infection on the association between human immunodeficiency virus type‐1 infection and hepatitis B viral replication. Twenty‐five chronic HBsAg carriers were studied.

Paolo Angeli, Erica De Bei, Manuela Dalla Pria, Lorenza Caregaro, Giulio Ceolotto, Grazia Albino, Angelo Gatta – 1 April 1992 – The reliability of lithium clearance as an index of distal fluid delivery in cirrhosis with ascites and in other clinical conditions characterized by low fractional sodium excretion has not yet been proven. In particular, lithium reabsorption in the amiloridesensitive segment of the distal tubule, as evidenced in experimental studies, has not been excluded in such clinical conditions.