Elisabetta Cariani, Antonella Ravaggi, Massimo Puoti, Giovanni Mantero, Alberto Albertini, Daniele Primi – 1 April 1992 – We developed a nonradioisotopic assay for detection of hepatitis delta virus RNA in serum by combining reverse transcription of RNA, polymerase chain reaction of the resultant complementary DNA and enzyme linked immunoassay detection of the polymerase chain reaction products using a monoclonal antibody specific for double‐stranded DNA.

G. Stephen Tint, Ashok K. Batta, Bishambar Dayal, Nina Kovell, Sarah Shefer, Gerald Salen – 1 April 1992 – To study the metabolism of ursocholic acid, control subjects were injected with radiolabeled cholic and ursocholic acids before and after 1 wk of 900 mg/day oral ursocholic acid. Daily samples of bile were obtained, and biliary bile acids were extracted and purified to determine bile acid kinetics.

Manal Shahin, Detlef Schuppan, Rüdiger Waldherr, Juha Risteli, Leila Risteli, Eeva‐Riitta Savolainen, Christine Oesterling, Hosna M. Abdel Rahman, Abdul M. El Sahly, Samia M. Abdel Razek, Omar El Ruby, Armin Koch, Helmut K. Seitz – 1 April 1992 – Schistosomiasis, in contrast to alcoholic liver disease, leads to presinusoidal hepatic fibrosis, which determines the prognosis of the disease.

Christopher Liddle, Michael Hollands, J. Miles Little, Geoffrey C. Farrell – 1 April 1992 – In both rats and humans, partial hepatectomy results in a substantial increase in serum estradiol concentrations. Because mammalian liver of both sexes contains estrogen receptor, it has been suggested that this surge in serum estrogen concentration may initiate or facilitate liver regeneration.

Mario Chojkier, Kenji Fujiwara, Itsuro Ogata – 1 April 1992

Raymond S. Koff – 1 April 1992

Robertson D. Davenport – 1 April 1992 – Prophylactic transfusions of fresh frozen plasma and platelets are sometimes given to patients with mild elevations in prothrombin time (PT) and partial thromboplastin time (PTF) and mild thrombocytopenia before percutaneous liver biopsy. To determine whether PTs and PTFs 1.1–1.5 times midrange normal levels and platelet counts 50–99 × 109/L are associated with increased bleeding complications, hospital records of all patients who underwent percutaneous liver biopsy during 56 consecutive months (n = 291) were reviewed.

James B. Burgess, Jacques U. Baenziger, William R. Brown – 1 April 1992 – Serum concentrations of asialoglycoproteins are increased in cirrhosis. We hypothesized that this increase results from abnormalities in the asialoglycoprotein receptor, which is located on the sinusoidal and lateral membrane of hepatocytes. Therefore we searched for morphological alterations in the distribution of the asialoglycoprotein receptor in human liver, using a light microscopic immunoperoxidase method in autopsy livers.

Gerald M. Kolodny – 1 April 1992

Giovanna Fattovich, Patrizia Farci, Massimo Rugge, Lucio Brollo, Antonella Mandas, Patrizia Pontisso, Giuliano Giustina, M. Eliana Lai, Fabio Belussi, Graziella Busatto, Angelo Balestrieri, Arturo Ruol, Alfredo Alberti – 1 April 1992 – Ongoing hepatitis B virus replication in the presence of antibody to HBeAg can be observed in patients with active liver disease. These forms of chronic hepatitis B have been described as having a poor prognosis.